Match!
Iris Asllani
Rochester Institute of Technology
14Publications
5H-index
41Citations
Publications 16
Newest
#2Jan Petr (RIT: Rochester Institute of Technology)H-Index: 1
Last.Frederik Barkhof (UCL: University College London)H-Index: 111
view all 42 authors...
Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers and scanners. The procedures used in ExploreASL capitalize on published image processing advancements and address the challenges ...
Source
Abstract Early nutritional deprivation may cause irreversible damage to the brain and seems to affect cognitive function in older age. We investigated whether prenatal undernutrition was associated with brain perfusion differences in older age. We acquired Arterial spin labelling scans in 118 Dutch famine birth cohort members. Using linear regression analyses, cerebral blood flow (CBF) was compared between exposed and unexposed groups in grey and white matter, perfusion territories, the neurodeg...
Source
#1Jan Petr (RIT: Rochester Institute of Technology)H-Index: 1
Last.Iris Asllani (RIT: Rochester Institute of Technology)H-Index: 5
view all 9 authors...
Objective Partial volume (PV) correction is an important step in arterial spin labeling (ASL) MRI that is used to separate perfusion from structural effects when computing the mean gray matter (GM) perfusion. There are three main methods for performing this correction: (1) GM-threshold, which includes only voxels with GM volume above a preset threshold; (2) GM-weighted, which uses voxel-wise GM contribution combined with thresholding; and (3) PVC, which applies a spatial linear regression algori...
2 CitationsSource
#1Feng Liu (Columbia University)H-Index: 31
#2Yunsuo Duan (Columbia University)H-Index: 10
Last.Alayar Kangarlu (Columbia University)H-Index: 17
view all 7 authors...
Abstract The development of brain circuits is coupled with changes in neurovascular coupling, which refers to the close relationship between neural activity and cerebral blood flow (CBF). Studying the characteristics of CBF during resting state in developing brain can be a complementary way to understand the functional connectivity of the developing brain. Arterial spin labeling (ASL), as a noninvasive MR technique, is particularly attractive for studying cerebral perfusion in children and even ...
5 CitationsSource
#1Jan Petr (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 12
#2Ivan Platzek (TUD: Dresden University of Technology)H-Index: 14
Last.Jörg van den Hoff (TUD: Dresden University of Technology)H-Index: 11
view all 16 authors...
Abstract Background and purpose To compare the structural and hemodynamic changes of healthy brain tissue in the cerebral hemisphere contralateral to the tumor following photon and proton radiochemotherapy. Materials and methods Sixty-seven patients (54.9 ±14.0 years) diagnosed with glioblastoma undergoing adjuvant photon ( n = 47) or proton ( n = 19) radiochemotherapy with temozolomide after tumor resection underwent T1-weighted and arterial spin labeling MRI. Changes in volume and perfusion be...
5 CitationsSource
#2Iris AsllaniH-Index: 5
Last.Ronald M. LazarH-Index: 45
view all 5 authors...
6 CitationsSource
#2Iris Asllani (RIT: Rochester Institute of Technology)H-Index: 5
Last.Ronald M. LazarH-Index: 45
view all 5 authors...
Objective: Cortical thinning has been reported in patients with cerebrovascular disease and degenerative dementia, but the direct impact of regional hypoperfusion on cortical pathology has been difficult to establish. We examined the association between regional cerebral blood flow (rCBF) and regional cortical thickness (rCT) in a cohort of patients with unilateral high-grade internal carotid artery (ICA) disease without history of stroke. Methods: Twenty-seven patients age 73±10yrs, 11F with un...
#1N. Doorenweerd (LUMC: Leiden University Medical Center)H-Index: 5
#2Eve M. Dumas (LUMC: Leiden University Medical Center)H-Index: 17
Last.Helinien E. Kan (LUMC: Leiden University Medical Center)H-Index: 1
view all 16 authors...
Abstract Duchenne muscular dystrophy is caused by dystrophin gene mutations which lead to the absence of the protein dystrophin. A significant proportion of patients suffer from learning and behavioural disabilities, in addition to muscle weakness. We have previously shown that these patients have a smaller total brain and grey matter volume, and altered white matter microstructure compared to healthy controls. Patients with more distal gene mutations, predicted to affect dystrophin isoforms Dp1...
7 CitationsSource
#1Hjmm MutsaertsH-Index: 1
#2Jan PetrH-Index: 12
Last.P.J. GrootH-Index: 31
view all 23 authors...
Arterial spin labeling (ASL) perfusion MRI1 is rapidly maturing as a research tool, potential future biomarker2 and pharmacological monitoring agent3 for many diseases including neurodegeneration. There is thus a growing need for standardization of ASL image processing and quality control (QC) for voxel-based (VBA) and region-of-interest (ROI)-based analyses. Here, we present ExploreASL, a non-commercial software package that aims to harmonize image processing for ASL perfusion images for single...
2 Citations
#1Randolph S. Marshall (Columbia University)H-Index: 29
#2Marykay A. Pavol (Columbia University)H-Index: 5
Last.Ronald M. Lazar (Columbia University)H-Index: 45
view all 7 authors...
Abstract Background Cerebral blood flow (CBF) regulation is a critical element in cerebrovascular pathophysiology, particularly in large vessel disease, but the best method to use for hemodynamic assessment is not clear. We examined 4 different blood-flow related measures in patients with unilateral high-grade carotid artery disease, assessing asymmetry between the occluded vs non-occluded side, and the correlations among the measures. Methods Thirty-three patients (age 50–93, 19 M) with unilate...
3 CitationsSource
12