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Stefan T. Arold
King Abdullah University of Science and Technology
155Publications
35H-index
4,988Citations
Publications 155
Newest
#1Haroon Butt (KAUST: King Abdullah University of Science and Technology)H-Index: 7
#2Ayman Eid (KAUST: King Abdullah University of Science and Technology)H-Index: 7
Last.Magdy M. Mahfouz (KAUST: King Abdullah University of Science and Technology)H-Index: 26
view all 7 authors...
Increasing genetic diversity via directed evolution holds great promise to accelerate trait development and crop improvement. We developed a CRISPR/Cas-based directed evolution platform in plants to evolve the rice (Oryza sativa) SF3B1 spliceosomal protein for resistance to splicing inhibitors. SF3B1 mutant variants, termed SF3B1-GEX1A-Resistant (SGR), confer variable levels of resistance to splicing inhibitors. Studies of the structural basis of the splicing inhibitor binding to SGRs corroborat...
#1Malak Alghamdi (KSU: King Saud University)
#2Stefan T. Arold (KAUST: King Abdullah University of Science and Technology)H-Index: 35
Last.Fahad A. Bashiri (KSU: King Saud University)H-Index: 9
view all 4 authors...
#1Tanvir Alam (KAUST: King Abdullah University of Science and Technology)H-Index: 9
#2Meshari Alazmi (KAUST: King Abdullah University of Science and Technology)H-Index: 3
Last.Stefan T. Arold (KAUST: King Abdullah University of Science and Technology)H-Index: 35
view all 13 authors...
We acknowledge SOLEIL for provision of synchrotron radiation facilities for testing of hundreds of FAT:LD motif peptide crystals, and we would like to thank Martin Savko, Gavin Fox, William Shepard, Serena Sirigu, Leonard Chavas and Pierre Legrand for assistance in using beamlines PROXIMA I and PROXIMA IIA. We acknowledge support from the KAUST Imaging and Characterization Core Lab and the Bioscience Core Lab. We thank John Hanks and Craig Kapfer for their assistance with use of the Dragon Clust...
#1Heike C. Hawerkamp (HHU: University of Düsseldorf)
#2Andreas Kislat (HHU: University of Düsseldorf)H-Index: 5
Last.Stephan Meller (HHU: University of Düsseldorf)H-Index: 25
view all 17 authors...
#1Saud Alsahli (BCM: Baylor College of Medicine)H-Index: 5
#2Ahmed Alfares (National Guard Health Affairs)H-Index: 6
Last.Fuad Al Mutairi (King Saud bin Abdulaziz University for Health Sciences)H-Index: 8
view all 6 authors...
Intellectual disability poses a huge burden on the health care system, and it is one of the most common referral reasons to the genetic and child neurology clinic. Intellectual disability (ID) is genetically heterogeneous, and it is associated with several other neurological conditions. Exome sequencing is a robust genetic tool and has revolutionized the process of molecular diagnosis and novel gene discovery. Besides its diagnostic clinical value, novel gene discovery is prime in reverse geneti...
#1Muhammad Jamil (KAUST: King Abdullah University of Science and Technology)H-Index: 14
#2Boubacar A. Kountche (KAUST: King Abdullah University of Science and Technology)H-Index: 6
Last.Salim Al-Babili (KAUST: King Abdullah University of Science and Technology)H-Index: 39
view all 14 authors...
Strigolactones (SLs) regulate plant development and induce seed germination in obligate root parasitic weeds, e.g. Striga spp. Because organic synthesis of natural SLs is laborious, there is a large need for easy-to-synthesize and efficient analogs. Here, we investigated the effect of a structural modification of the D-ring, a conserved structural element in SLs. We synthesized and investigated the activity of two analogs, MP13 and MP26, which differ from previously published AR8 and AR36 only i...
#1Umar Farook Shahul Hameed (KAUST: King Abdullah University of Science and Technology)H-Index: 4
#2Chenyi Liao (UVM: University of Vermont)H-Index: 7
Last.Stefan T. Arold (KAUST: King Abdullah University of Science and Technology)H-Index: 35
view all 18 authors...
ACKNOWLEDGEMENTS: We thank the Berkeley Laboratory Advanced Light Source and SIBYLS beamline staff at 12.3.1 for assistance with collection of SAXS data, and K. Dyer for the mail-in service provided by SIBYLS. We acknowledge SOLEIL for provision of synchrotron radiation facilities and we would like to thank J. Perez and A. Thureau for assistance in using the beamline SWING. We thank the KAUST Bioscience and Imaging core labs for their assistance. Computational resources were provided to J.L. by ...
#1Ranad ShaheenH-Index: 27
Last.Fowzan S. Alkuraya (Alfaisal University)H-Index: 50
view all 47 authors...
Congenital microcephaly (CM) is an important birth defect with long term neurological sequelae. We aimed to perform detailed phenotypic and genomic analysis of patients with Mendelian forms of CM. Clinical phenotyping, targeted or exome sequencing, and autozygome analysis. We describe 150 patients (104 families) with 56 Mendelian forms of CM. Our data show little overlap with the genetic causes of postnatal microcephaly. We also show that a broad definition of primary microcephaly —as an autosom...
#1Elizabeth E. PalmerH-Index: 11
#2Seungbeom Hong (KAUST: King Abdullah University of Science and Technology)H-Index: 1
Last.Stefan T. Arold (KAUST: King Abdullah University of Science and Technology)H-Index: 35
view all 43 authors...
Polyglutamine expansions in the transcriptional co-repressor Atrophin-1, encoded by ATN1, cause the neurodegenerative condition dentatorubral-pallidoluysian atrophy (DRPLA) via a proposed novel toxic gain of function. We present detailed phenotypic information on eight unrelated individuals who have de novo missense and insertion variants within a conserved 16-amino-acid “HX repeat” motif of ATN1. Each of the affected individuals has severe cognitive impairment and hypotonia, a recognizable faci...
#1Liana Adam (University of Texas MD Anderson Cancer Center)H-Index: 38
#2F. Anthony San Lucas (University of Texas MD Anderson Cancer Center)H-Index: 11
Last.Michael J. Overman (University of Texas MD Anderson Cancer Center)H-Index: 37
view all 16 authors...
Purpose: Little is known about the genetic alterations characteristic of small bowel adenocarcinoma (SBA). Our purpose was to identify targetable alterations and develop experimental models of this disease. Experimental Design: Whole-exome sequencing (WES) was completed on 17 SBA patient samples and targeted-exome sequencing (TES) on 27 samples to confirm relevant driver mutations. Two SBA models with ERBB2 kinase activating mutations were tested for sensitivity to anti-ERBB2 agents in vivo and ...
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