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Darya V. Telegina
Russian Academy of Sciences
10Publications
4H-index
39Citations
Publications 10
Newest
Age-related macular degeneration (AMD) is one of the main causes of vision impairment in the elderly. Autophagy is the process of delivery of cytoplasmic components into lysosomes for cleavage; its age-related malfunction may contribute to AMD. Here we showed that the development of AMD-like retinopathy in OXYS rats is accompanied by retinal transcriptome changes affecting genes involved in autophagy. These genes are associated with kinase activity, immune processes, and FoxO, mTOR, PI3K-AKT, MA...
Background Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of AMD is poorly understood. A large body of evidence has corroborated the key role of neurotrophins in development, proliferation, differentiation, and survival of retinal cells. Neurotrophin deprivation has been proposed to contribute to retinal-cell death associated with neurodegenerative diseases. Little is known about the expression of the immature form of n...
#1Darya V. Telegina (RAS: Russian Academy of Sciences)H-Index: 4
#2Oyuna S. Kozhevnikova (RAS: Russian Academy of Sciences)H-Index: 6
Last.Nataliya G. Kolosova (RAS: Russian Academy of Sciences)H-Index: 12
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Age is the major risk factor in the age-related macular degeneration (AMD) which is a complex multifactor neurodegenerative disease of the retina and the main cause of irreversible vision loss in people over 60 years old. The major role in AMD pathogenesis belongs to structure-functional changes in the retinal pigment epithelium cells, while the onset and progression of AMD are commonly believed to be caused by the immune system dysfunctions. The role of retinal glial cells (Muller cells, astroc...
#2Darya V. TeleginaH-Index: 4
Last.Nataliya G. Kolosova (NSU: Novosibirsk State University)H-Index: 12
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Age-related macular degeneration (AMD) is a complex neurodegenerative disease resulting in a loss of central vision in the elderly. It is currently assumed that impairment of autophagy may be one of the key mechanisms leading to AMD. Here we estimated the influence of age-related autophagy alterations in the retina on the development of AMD-like retinopathy in senescence-accelerated OXYS rats. Significant changes in the expression of the autophagy proteins were absent at the age preceding the de...
Contributions of age-related alterations of the retinal pigment epithelium and of glia to the AMD-like pathology in OXYS rats
#1Darya V. Telegina (RAS: Russian Academy of Sciences)H-Index: 4
#2Oyuna S. Kozhevnikova (RAS: Russian Academy of Sciences)H-Index: 6
Last.N. G. Kolosova (RAS: Russian Academy of Sciences)H-Index: 12
view all 3 authors...
Age-related macular degeneration (AMD) is a chronic progressive disease characterized by damage to the central retina zone. Changes in choriocapillaries, retinal pigment epithelium (RPE), and Bruch’s membrane (typical for aging) underlie AMD pathogenesis; however, the mechanisms launching the transfer of typical age-related changes in the pathological process are unknown. The death of photoreceptors and irreversible loss of vision become the results of pathological changes in RPE and choroid. In...
#1Darya V. TeleginaH-Index: 4
view all 3 authors...
Abstract Age-related macular degeneration (AMD) is a chronic progressive disease characterized by lesions in the central area of the retina. The pathogenesis of AMD involves aging-associated changes in the choriocapillaris, retinal pigment epithelium (RPE), and in Bruch's membrane, but the mechanisms that trigger the conversion of normal age-related changes into the pathological process are not known. The result of pathological changes in the RPE and choroid is the death of photoreceptors and ir...
#1Darya V. TeleginaH-Index: 4
#2Elena E. KorbolinaH-Index: 6
Last.Oyuna S. KozhevnikovaH-Index: 6
view all 5 authors...
Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of early events in AMD is poorly understood. Senescence-accelerated OXYS rats develop AMD-like retinopathy. The aim of this study was to explore the differences in retinal gene expression between OXYS and Wistar (control) rats at age 20 d and to identify the pathways of retinal cell death involved in the OXYS retinopathy initiation and progression. Retinal mRNA profiles of ...
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