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Rebecca Spencer
University College London
ObstetricsFetusCohort studyPregnancyMedicine
19Publications
4H-index
140Citations
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Publications 19
Newest
#1Rosalind Aughwane (UCL: University College London)H-Index: 4
#2Nada Mufti (UCL: University College London)
Last. Jan Deprest (UCL: University College London)H-Index: 67
view all 14 authors...
OBJECTIVE We hypothesized that a multi-compartment MRI technique that is sensitive to fetal blood oxygenation would identify changes in placental blood volume and fetal blood oxygenation in pregnancies complicated by early-onset Fetal Growth Restriction (FGR). DESIGN Case-Control study. SETTING London, UK. POPULATION Women with uncomplicated pregnancies (estimated fetal weight, EFW>10th centile for gestational age, GA and normal maternal and fetal Doppler ultrasound, n=12) or early-onset FGR (EF...
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#1Natalie J. Hannan (University of Melbourne)H-Index: 28
#2Owen M Stock (University of Melbourne)H-Index: 9
Last. Sean K.M. SeehoH-Index: 8
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BACKGROUND: Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted and acidemic, and can demise. Preterm fetal growth restriction is a severe form of placental insufficiency with a high risk of stillbirth. We set out to identify maternal circulating mRNA transcripts that are differentially expressed in preterm pregnancies complicated by very severe placental insufficiency, in utero fetal acidemia, and are at very high risk of still...
1 CitationsSource
#1Rebecca Spencer (UCL: University College London)H-Index: 4
#2C Rossi (UCL: University College London)H-Index: 5
Last. Anna L. David (UCL: University College London)H-Index: 31
view all 12 authors...
Objective: To determine whether a novel therapy for placental insufficiency could achieve orphan drug status by estimating the annual incidence of placental insufficiency, defined as an estimated fetal weight below the 10th centile in the presence of abnormal umbilical artery Doppler velocimetry, per 10 000 European Union (EU) population as part of an application for European Medicines Agency (EMA) orphan designation. Design: Incidence estimation based on literature review and published national...
1 CitationsSource
#1Merryl HarveyH-Index: 6
#2Anna L. DavidH-Index: 31
Last. Rebecca SpencerH-Index: 4
view all 4 authors...
Abstract Background: The EVERREST Prospective Study is a multicentre observational cohort study of pregnancies affected by severe early-onset fetal growth restriction. The study recruits women with singleton pregnancies where the estimated fetal weight is less than the 3rd centile and below 600 g, between 20 + 0 and 26 + 6 weeks of pregnancy, in the absence of a known chromosomal, structural or infective cause. Method: The reported study was retrospective descriptive qualitative interview study ...
#1Merryl Harvey (BCU: Birmingham City University)H-Index: 6
#2Anna L. David (UCL: University College London)H-Index: 31
Last. Rebecca Spencer (UCL: University College London)H-Index: 4
view all 4 authors...
Background The EVERREST Prospective Study is a multicentre observational cohort study of pregnancies affected by severe early-onset fetal growth restriction. The study recruits women with singleton pregnancies where the estimated fetal weight is less than the 3rd centile and below 600 g, between 20 + 0 and 26 + 6 weeks of pregnancy, in the absence of a known chromosomal, structural or infective cause.
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#1Rosalind AughwaneH-Index: 4
#2Magdalena SokolskaH-Index: 8
Last. Anna L. DavidH-Index: 31
view all 14 authors...
#1Rebecca SpencerH-Index: 4
#2DJ CarrH-Index: 9
Last. Anna L. DavidH-Index: 31
view all 3 authors...
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#2Simon S. SkeneH-Index: 8
Last. Rebecca SpencerH-Index: 4
view all 7 authors...
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#1Andrew Sharp (University of Liverpool)H-Index: 13
#2Christine Cornforth (University of Liverpool)H-Index: 2
Last. G. J. BuggH-Index: 5
view all 44 authors...
Summary Background Severe early-onset fetal growth restriction can lead to a range of adverse outcomes including fetal or neonatal death, neurodisability, and lifelong risks to the health of the affected child. Sildenafil, a phosphodiesterase type 5 inhibitor, potentiates the actions of nitric oxide, which leads to vasodilatation of the uterine vessels and might improve fetal growth in utero. Methods We did this superiority, placebo-controlled randomised trial in 19 fetal medicine units in the U...
59 CitationsSource
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