David A. Schwartz
University of Colorado Denver
Publications 1308
#1Susan K. Mathai (University of Colorado Denver)H-Index: 8
#2David A. Schwartz (University of Colorado Denver)H-Index: 97
Last.Raphael Borie (French Institute of Health and Medical Research)H-Index: 24
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Abstract Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterized by inflammation and, in some cases, fibrosis of the space between alveoli. These lung conditions lead to dyspnea, cough, abnormalities in gas exchange, restrictive physiology (characterized by decreased lung volumes), hypoxemia, and, if progressive, respiratory failure. In some cases, ILD can be caused by systemic disease or environmental exposures. The ability to treat or cure these ILDs varies bas...
#1Elizabeth A. Scoville (VUMC: Vanderbilt University Medical Center)H-Index: 6
#2Margaret M. Allaman (VUMC: Vanderbilt University Medical Center)H-Index: 8
Last.Lori A. Coburn (VUMC: Vanderbilt University Medical Center)H-Index: 15
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Crohn’s disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and adipokines. Serum was prospectively collected from 116 CD subjects and 27 non-IBD controls. Clinical disease activity was assessed by the Harvey Bradshaw Index (HBI). Serum fatty aci...
2 CitationsSource
#1Yaakov DicksteinH-Index: 10
#2Elizabeth TemkinH-Index: 8
Last.Mitchell J. Schwaber (TAU: Tel Aviv University)H-Index: 40
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We analyzed Israeli national data on antimicrobial susceptibility from bloodstream isolates collected between 2014 and 2017 and compared resistance proportions with those of Europe. The incidence of bloodstream infection (BSI) caused by most antibiotic-resistant organisms remained unchanged or decreased. An exception was increased incidence of BSI caused by third-generation cephalosporin-resistant Escherichia coli. Overall, resistance proportions were similar to those observed in southern Europe...
Purpose of Review As research efforts have advanced to understand the pathophysiology of viral hemorrhagic fevers (VHF) and other epidemic viral infections and develop medical countermeasures such as vaccines, pregnant women have remained an underexamined subgroup. To better understand the implications of future outbreaks of VHF for pregnant women amidst an evolving vaccine landscape, we examine three pathogens—yellow fever, Ebola, and Lassa fever—each with different levels of evidence and under...
1 CitationsSource
Introduction Idiopathic pulmonary fibrosis (IPF) is a devastating incurable lung disease. There have been three previous genome-wide association studies (GWAS) of IPF susceptibility. By combining these studies, we were able to perform the largest, densest and most powerful GWAS of IPF to date. Methods We used a two-stage approach. Stage 1 consisted of a genome-wide meta-analysis of IPF across the three previous studies. European cases and controls in each of the studies was imputed using the Hap...
Purpose of Review Pregnant women, their fetuses, and infants are at a high risk of exposure to infectious diseases, especially in low-income regions of the world where vaccine-preventable diseases are prevalent. Vaccines administered during pregnancy can protect not only pregnant women against infection-related morbidity and mortality, but also their fetuses and infants against preterm delivery, perinatal death, and disability. This article analyzes current issues related to maternal vaccination...
Purpose of Review Ebola virus infection has one of the highest overall case fatality rates of any viral disease. It has historically had an especially high case mortality rate among pregnant women and infants—greater than 90% for pregnant women in some outbreaks and close to 100 % in fetuses and newborns. The Merck recombinant vaccine against Ebola virus, termed rVSV-ZEBOV, underwent clinical trials during the 2013–2015 West Africa Ebola epidemic where it was found to be 100% efficacious. It was...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Geno...