Steven E. Kahn
University of Washington
EndocrinologyType 2 diabetesInsulinDiabetes mellitusMedicine
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Publications 481
#1Matthew C. Riddle (OHSU: Oregon Health & Science University)H-Index: 54
#2John B. Buse (UNC: University of North Carolina at Chapel Hill)H-Index: 97
Last. Steven E. Kahn (UW: University of Washington)H-Index: 98
view all 8 authors...
#1Pandora L. Wander (UW: University of Washington)H-Index: 6
#2Daniel A. Enquobahrie (UW: University of Washington)H-Index: 24
Last. Edward J. Boyko (UW: University of Washington)H-Index: 73
view all 9 authors...
Epigenetic changes precede the development of diabetes by many years, providing clues to its pathogenesis. We explored whether the epigenetic markers, circulating microRNAs (miRNAs), were associated with incident diabetes in Japanese Americans. We conducted a pilot study (n = 10) using plasma from age- and sex-matched participants who did or did not develop diabetes in the Japanese American Community Diabetes Study, an observational study of diabetes risk factors. Extraction and high-throughput ...
#1Jerry P. Palmer (UW: University of Washington)H-Index: 62
#2Steven E. Kahn (UW: University of Washington)H-Index: 98
Last. Stephen C. Woods (UC: University of Cincinnati)H-Index: 106
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Daniel Porte Jr. was born in New York City in 1931, and with his father being a clinical cardiologist, medicine was part of his life from very early on. After completing his undergraduate studies at Brown University, he commenced his migration west by first attending medical school at the University of Chicago, where he graduated with honors in 1957. Completing his westward migration, Dan moved to San Francisco for his internship and residency training in medicine in the University of California...
#1Melony Fortuin-de Smidt (UCT: University of Cape Town)H-Index: 2
#2Amy E. Mendham (UCT: University of Cape Town)H-Index: 7
Last. Lisa K. Micklesfield (UCT: University of Cape Town)H-Index: 19
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#1Sun Ok Song (UW: University of Washington)H-Index: 10
#2You Cheol Hwang (Kyung Hee University)H-Index: 8
Last. Edward J. Boyko (UW: University of Washington)H-Index: 73
view all 6 authors...
BACKGROUND: We describe the association between high density lipoprotein cholesterol (HDL-C) concentration and computed tomography (CT)-measured fat depots. METHODS: We examined the cross-sectional associations between HDL-C concentration and intra-abdominal (IAF), abdominal subcutaneous (SCF), and thigh fat (TF) areas in 641 Japanese-American men and women. IAF, SCF, and TF were measured by CT at the level of the umbilicus and mid-thigh. The associations between fat area measurements and HDL-C ...
#1Jia Y. Wan (UCI: University of California, Irvine)H-Index: 7
#2Christina Cataby (UCI: University of California, Irvine)
Last. David C. RobbinsH-Index: 44
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Abstract Background This study investigated the relationship between smoking and hearing loss and deafness (HLD) and whether the relationship is modified by genetic variation. Data for these analyses was from the subset of Japanese American families collected as part of the American Diabetes Association Genetics of Non-insulin Dependent Diabetes Mellitus study. Logistic regression with generalized estimating equations assessed the relationship between HLD and smoking. Nonparametric linkage analy...
#1Moira L. Aitken (UW: University of Washington)H-Index: 47
#2Magdalena A. Szkudlinska (UW: University of Washington)H-Index: 1
Last. Steven E. Kahn (UW: University of Washington)H-Index: 98
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The aim of this study was to determine the mechanism(s) for hypoglycaemia occurring late following oral glucose loading in patients with cystic fibrosis (CF). A 3 h 75 g OGTT was performed in 27 non-diabetic adults with CF who were classified based on this test as experiencing hypoglycaemia (glucose <3.3 mmol/l with or without symptoms or glucose <3.9 mmol/l with symptoms, n = 14) or not (n = 13). Beta cell function, incretin (glucagon-like peptide-1 [GLP-1] and glucose-dependent insulinotropic ...
#1Jordi MerinoH-Index: 11
#2Kathleen A. Jablonski (GW: George Washington University)H-Index: 40
Last. Jose C. FlorezH-Index: 73
view all 14 authors...
Coronary artery disease (CAD) is more frequent among individuals with dysglycemia. Preventive interventions for diabetes can improve cardiometabolic risk factors (CRFs), but it is unclear whether the benefits on CRFs are similar for individuals at different genetic risk for CAD. We built a 201-variant polygenic risk score (PRS) for CAD and tested for interaction with diabetes prevention strategies on one-year changes in CRFs in 2,658 Diabetes Prevention Program participants. We also examined whe...
#1Andrew T. Templin (UW: University of Washington)H-Index: 3
#2Mahnaz Mellati (UW: University of Washington)H-Index: 3
Last. Rebecca L. Hull (UW: University of Washington)H-Index: 30
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Islet amyloid is a pathologic feature of type 2 diabetes (T2D) that is associated with beta-cell loss and dysfunction. These amyloid deposits form via aggregation of the beta-cell secretory product islet amyloid polypeptide (IAPP) and contain other molecules including the heparan sulfate proteoglycan perlecan. Perlecan has been shown to bind amyloidogenic human IAPP (hIAPP) via its heparan sulfate glycosaminoglycan (HS GAG) chains and to enhance hIAPP aggregation in vitro. We postulated that red...
#1Kristina M. Utzschneider (UW: University of Washington)H-Index: 35
#2Steven E. Kahn (UW: University of Washington)H-Index: 98
Last. David Polidori (Janssen Pharmaceutica)H-Index: 26
view all 3 authors...