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Wen-Ming Li
Chongqing Medical University
10Publications
9H-index
344Citations
Publications 10
Newest
Published on Jun 17, 2011in Molecular Medicine Reports 1.85
Hai-Zhong Liu3
Estimated H-index: 3
(CQMU: Chongqing Medical University),
Chao Yu17
Estimated H-index: 17
(CQMU: Chongqing Medical University)
+ 6 AuthorsYingxiong Wang15
Estimated H-index: 15
(CQMU: Chongqing Medical University)
Published on May 31, 2011in Oncology Reports 3.04
Juan Yin4
Estimated H-index: 4
(CQMU: Chongqing Medical University),
Chao Yu17
Estimated H-index: 17
+ 6 AuthorsYingxiong Wang15
Estimated H-index: 15
Published on Jun 1, 2010in Inflammation Research 3.06
Hongtao Liu17
Estimated H-index: 17
(CAS: Chinese Academy of Sciences),
Jun-Lin He4
Estimated H-index: 4
(CQMU: Chongqing Medical University)
+ 5 AuthorsChao Yu17
Estimated H-index: 17
(CQMU: Chongqing Medical University)
Objective The aim of this study was to investigate the inhibitory effect of geniposide on lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) and interleukin-8 (IL-8) production in human umbilical vein endothelial cells (HUVECs).
Published on Jun 1, 2010in Journal of Ethnopharmacology 3.41
Hongtao Liu17
Estimated H-index: 17
(CQMU: Chongqing Medical University),
Yuguang Du31
Estimated H-index: 31
(DICP: Dalian Institute of Chemical Physics)
+ 5 AuthorsChao Yu17
Estimated H-index: 17
(CQMU: Chongqing Medical University)
Abstract Aim of the study To determine the inhibitory effect of tetramethylpyrazine (TMP) on lipopolysaccharide (LPS)-induced over-production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in N9 microglial cells. Materials and methods N9 cells were pretreated with vehicle or TMP and then exposed to LPS for the time indicated. Cell viability was determined by methylthiazoyltetrazolium (MTT) assay. Nitrite assay was performed by Griess reaction. Expression of iNOS mRNA was examine...
Published on May 1, 2010in Carbohydrate Polymers 6.04
Hongtao Liu17
Estimated H-index: 17
(CAS: Chinese Academy of Sciences),
Jun-Lin He4
Estimated H-index: 4
(CQMU: Chongqing Medical University)
+ 5 AuthorsYuguang Du31
Estimated H-index: 31
(DICP: Dalian Institute of Chemical Physics)
Abstract This study aimed to investigate the protective effect of chitosan oligosaccharides (COS) on human umbilical vein endothelial cell (HUVEC) apoptosis induced by hydrogen peroxide (H 2 O 2 ). We found that COS not only reversed the decrease of cell viability and proliferation activity, but ameliorated nuclear chromatin damage in H 2 O 2 -induced HUVECs. Additionally, COS contributed to the decrease of cytosolic Ca 2+ level, increase of mitochondrial membrane potential, up-regulation of Bcl...
Published on May 1, 2010in Carbohydrate Polymers 6.04
Hongtao Liu17
Estimated H-index: 17
(CAS: Chinese Academy of Sciences),
Wen-Ming Li9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
+ 5 AuthorsYuguang Du31
Estimated H-index: 31
(DICP: Dalian Institute of Chemical Physics)
Abstract This study aimed to investigate the inhibitive effects of chitosan oligosaccharides (COS) on tumor necrosis factor (TNF)-α-induced over-expression of vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs). We found that COS effectively inhibited TNF-α-induced expression of VCAM-1 and ICAM-1 at the level of transcription and translation. Signal transduction studies suggested that COS blocked TNF-α-induced ac...
Published on Nov 1, 2009in Basic & Clinical Pharmacology & Toxicology 2.45
Hongtao Liu17
Estimated H-index: 17
(CAS: Chinese Academy of Sciences),
Wen-Ming Li9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
+ 5 AuthorsYuguang Du31
Estimated H-index: 31
(DICP: Dalian Institute of Chemical Physics)
Abstract: Chitosan oligosaccharides (COS) have been reported to exert anti-fungal activities, antitumour activities and immuno-enhancing effects. However, the potential roles of COS in the treatment of vascular inflammations remain unknown. In the present study, we examined the effects of COS on interleukin-6 (IL-6) production in human umbilical vein endothelial cells (HUVECs) induced by lipopolysaccharide (LPS). Induction of HUVECs with LPS (100 ng/ml) increased the mRNA expression and protein ...
Published on Oct 1, 2009in Basic & Clinical Pharmacology & Toxicology 2.45
Wen-Ming Li9
Estimated H-index: 9
(CQMU: Chongqing Medical University),
Hongtao Liu17
Estimated H-index: 17
(CQMU: Chongqing Medical University)
+ 5 AuthorsChao Yu17
Estimated H-index: 17
(CQMU: Chongqing Medical University)
Tetramethylpyrazine has been widely used in traditional Chinese medicine to treat cardiovascular diseases such as atherosclerosis and hypertension. The underlying mechanism of cardioprotective effects, however, remains to be elucidated. Here, using human umbilical vein endothelial cells (HUVECs), we have assessed the protective effect of tetramethylpyrazine on H(2)O(2)-induced oxidative damage. After pre-incubation with tetramethylpyrazine (50, 100 and 150 mu g/ml) for 24 hr., viability loss in ...
Published on Aug 1, 2009in Journal of Ethnopharmacology 3.41
Xiu-Ying Li4
Estimated H-index: 4
(CQMU: Chongqing Medical University),
Jun-Lin He4
Estimated H-index: 4
(CQMU: Chongqing Medical University)
+ 2 AuthorsChao Yu17
Estimated H-index: 17
(CQMU: Chongqing Medical University)
Abstract Aim of the study To determine the anti-inflammatory effects of Tetramethylpyrazine (TMP) and to investigate the inhibitory effect of TMP on IL-8 production in human umbilical vein endothelial cells (HUVECs) induced by LPS might be mediated by inhibiting p38, ERK and NF-κB signaling pathways. Materials and methods HUVECs were treated with or without TMP for 24 h before exposure to LPS for 4 h. IL-8 gene and protein expressions were determined by RT-PCR and ELISA. Cell viability was deter...
Published on Mar 1, 2009in Pharmacological Research 5.57
Hongtao Liu17
Estimated H-index: 17
(CAS: Chinese Academy of Sciences),
Wen-Ming Li9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
+ 5 AuthorsYuguang Du31
Estimated H-index: 31
(DICP: Dalian Institute of Chemical Physics)
Abstract Chitosan oligosaccharides (COS) have been reported to have anticancer activity, immuno-enhancing effect and antimicrobial activity. However, other biological activities are unknown. Herein, we investigated the protective effects of COS against hydrogen peroxide (H 2 O 2 )-induced oxidative damage on human umbilical vein endothelial cells (HUVEC, ECV304 cells). After 24 h pre-incubation with COS (25–200 μg/ml), the viability loss in ECV304 cells induced by H 2 O 2 (300 μM) for 12 h was m...
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