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Steven C. Elbein
Wake Forest University
122Publications
37H-index
4,828Citations
Publications 122
Newest
Published on Aug 1, 2012in Metabolic Syndrome and Related Disorders1.60
Ashis K. Mondal11
Estimated H-index: 11
,
Swapan K Das33
Estimated H-index: 33
+ 5 AuthorsGouri Ranganathan20
Estimated H-index: 20
Abstract The endoplasmic reticulum (ER) of adipocytes plays a major role in the assembly and secretion of adipokines. The levels of serum adiponectin, secreted by adipocytes, are decreased in insulin resistance, diabetes, and obesity. The role of ER stress in downregulating adiponectin levels has been demonstrated in mouse models of obesity. Studies examining human adipose tissue have indicated that there is an increase in the ER stress transcript HSPA5 with increased body mass index (BMI). Howe...
Published on Jul 1, 2012in Pharmacogenetics and Genomics2.69
Neda Rasouli30
Estimated H-index: 30
,
Philip A. Kern54
Estimated H-index: 54
+ 2 AuthorsSwapan K Das33
Estimated H-index: 33
Objectives We aimed to define effects of PPARγ and PPARα agonist mono and combination therapy on adipose tissue and skeletal muscle gene expression in relation to insulin sensitivity. We further investigated the role of genetic polymorphisms in PPAR ligand-modulated genes in transcriptional regulation and glucose homeostasis.
Published on Mar 1, 2011in Diabetes7.20
Steven C. Elbein37
Estimated H-index: 37
,
Philip A. Kern54
Estimated H-index: 54
+ 3 AuthorsSwapan K Das33
Estimated H-index: 33
OBJECTIVE To determine altered gene expression profiles in subcutaneous adipose and skeletal muscle from nondiabetic, insulin-resistant individuals compared with insulin-sensitive individuals matched for BMI. RESEARCH DESIGN AND METHODS A total of 62 nondiabetic individuals were chosen for extremes of insulin sensitivity (31 insulin-resistant and 31 insulin-sensitive subjects; 40 were European American and 22 were African American) and matched for age and obesity measures. Global gene expression...
Mariana Murea16
Estimated H-index: 16
,
Barry I. Freedman71
Estimated H-index: 71
+ 3 AuthorsLijun Ma19
Estimated H-index: 19
Cellular toxicity mediated by lipids (lipotoxicity) has been implicated in the pathophysiology of metabolic syndrome and diabetes mellitus. Genetic analyses now implicate lipotoxicity in susceptibility to type 2 diabetes mellitus-associated nephropathy (T2DN), a pathway that had previously been unexplored. A genome-wide association study in Japanese patients identified a single nucleotide polymorphism in the acetyl-CoA carboxylase β ( ACACB ) gene associated with T2DN. Replication analyses sugge...
Published on Dec 1, 2010in Nephrology Dialysis Transplantation4.20
Cso Tang39
Estimated H-index: 39
(HKU: University of Hong Kong),
Violet T.M. Leung1
Estimated H-index: 1
+ 12 AuthorsSteven C. Elbein37
Estimated H-index: 37
Background. A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant. Methods. Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or ...
Published on Aug 1, 2010in Journal of Lipid Research4.74
Swapan K Das33
Estimated H-index: 33
,
Ashis K. Mondal11
Estimated H-index: 11
,
Steven C. Elbein37
Estimated H-index: 37
Obese individuals are both insulin resistant and have high levels of circulating free fatty acids (FFAs). In cell culture, saturated but not unsaturated fatty acids induce endoplasmic reticulum (ER) stress. We hypothesized that chronic exposure to low dose fatty acids would significantly attenuate the acute stress response to a saturated fatty acid challenge and that unsaturated fatty acids (oleate) would be more protective than saturated fatty acids (palmitate). The ER stress response to palmit...
Published on Feb 1, 2010in Molecular Endocrinology3.63
Ashis K. Mondal11
Estimated H-index: 11
,
Swapan K Das33
Estimated H-index: 33
+ 6 AuthorsSteven C. Elbein37
Estimated H-index: 37
Published on Jan 1, 2010in Disease Markers2.76
Swapan K Das33
Estimated H-index: 33
,
Neeraj K. Sharma10
Estimated H-index: 10
,
Steven C. Elbein37
Estimated H-index: 37
Recent studies in mice and human identified osteocalcin (OCN) as a bone-derived hormone that modulates insulin secretion and insulin sensitivity. OCN is synthesized by the bone gamma-carboxyglutamate protein (BGLAP) gene located in the well replicated region of type 2 diabetes (T2D) linkage on chromosome 1q22. We resequenced BGLAP gene in 192 individuals with T2D and performed case-control studies in 766 Caucasian (461 T2D and 305 controls) and 563 African American individuals (371 T2D and 192 c...
Steven C. Elbein37
Estimated H-index: 37
(University of Arkansas for Medical Sciences)
Type 2 diabetes mellitus (T2DM) is among the many common diseases with a strong genetic component, but until recently, the variants causing this disease remained largely undiscovered. With the ability to interrogate most of the variation in the genome, the number of genetic variants has grown from 2 to 19 genes, many with multiple variants. An additional three genes are associated primarily with fasting glucose rather than T2DM. Despite the plethora of new markers, the individual effect is unifo...
Published on Jul 1, 2009in Diabetes7.20
Inga Prokopenko70
Estimated H-index: 70
(NIHR: National Institute for Health Research),
Eleftheria Zeggini69
Estimated H-index: 69
+ 29 AuthorsMao Fu17
Estimated H-index: 17
(PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)
OBJECTIVE Linkage of the chromosome 1q21–25 region to type 2 diabetes has been demonstrated in multiple ethnic groups. We performed common variant fine-mapping across a 23-Mb interval in a multiethnic sample to search for variants responsible for this linkage signal. RESEARCH DESIGN AND METHODS In all, 5,290 single nucleotide polymorphisms (SNPs) were successfully genotyped in 3,179 type 2 diabetes case and control subjects from eight populations with evidence of 1q linkage. Samples were ascerta...
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