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Steven C. Elbein
University of Arkansas for Medical Sciences
EndocrinologyType 2 diabetesGeneticsDiabetes mellitusBiology
109Publications
37H-index
4,725Citations
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Publications 119
Newest
#1Ashis K. Mondal (Wake Forest University)H-Index: 11
#2Neeraj K. Sharma (Wake Forest University)H-Index: 11
Last. Swapan K Das (Wake Forest University)H-Index: 32
view all 4 authors...
Type 2 diabetes (T2D)-associated SNPs are more likely to be expression quantitative trait loci (eQTLs). The allelic expression imbalance (AEI) analysis is the measure of relative expression between two allelic transcripts and is the most sensitive measurement to detect cis-regulatory effects. We performed AEI screening to detect cis-regulators for genes expressed in transformed lymphocytes of 190 Caucasian (CA) and African American (AA) subjects to identify functional variants for T2D susceptibi...
5 CitationsSource
#1Sandra J. HasstedtH-Index: 44
#2Heather M. Highland (University of Texas Health Science Center at Houston)H-Index: 16
Last. Swapan K Das (Wake Forest University)H-Index: 32
view all 5 authors...
We previously localized type 2 diabetes (T2D) susceptibility genes to five chromosomal regions through a genome-wide linkage scan of T2D and age of diagnosis (AOD) in the African American subset of the GENNID sample. To follow up these findings, we repeated the linkage and association analysis using genotypes on an additional 9,203 fine-mapping SNPs selected to tag genes under the linkage peaks. In each of the five regions, we confirmed linkage and inferred the presence two or more susceptibilit...
6 CitationsSource
#1Lijun Ma (Wake Forest University)H-Index: 20
#2Mariana Murea (Wake Forest University)H-Index: 18
Last. Barry I. Freedman (Wake Forest University)H-Index: 72
view all 33 authors...
Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity. This study assessed relationships between rs2268388, body mass index (BMI) and gene expression in multiple populations, with and without T2DM. Among subjects without T2DM, rs2268388 DN risk allele (T) associated with higher BMI in Pima Indian children (n = 2021; p-addit...
6 CitationsSource
#1Steven C. Elbein (Wake Forest University)H-Index: 8
#2Eric R. Gamazon (U of C: University of Chicago)H-Index: 39
Last. Nancy J. Cox (U of C: University of Chicago)H-Index: 124
view all 6 authors...
To date, 68 loci have been associated with type 2 diabetes (T2D) or glucose homeostasis traits. We report here the results of experiments aimed at functionally characterizing the SNPs replicated for T2D and glucose traits. We sought to determine whether these loci were associated with transcript levels in adipose, muscle, liver, lymphocytes, and pancreatic β-cells. We found an excess of trans, rather than cis, associations among these SNPs in comparison to what was expected in adipose and muscle...
26 CitationsSource
Abstract The endoplasmic reticulum (ER) of adipocytes plays a major role in the assembly and secretion of adipokines. The levels of serum adiponectin, secreted by adipocytes, are decreased in insulin resistance, diabetes, and obesity. The role of ER stress in downregulating adiponectin levels has been demonstrated in mouse models of obesity. Studies examining human adipose tissue have indicated that there is an increase in the ER stress transcript HSPA5 with increased body mass index (BMI). Howe...
27 CitationsSource
#1Neda RasouliH-Index: 32
#2Philip A. KernH-Index: 54
Last. Swapan K DasH-Index: 32
view all 5 authors...
Objectives We aimed to define effects of PPARγ and PPARα agonist mono and combination therapy on adipose tissue and skeletal muscle gene expression in relation to insulin sensitivity. We further investigated the role of genetic polymorphisms in PPAR ligand-modulated genes in transcriptional regulation and glucose homeostasis.
20 CitationsSource
#1Kurt A. Langberg (Wake Forest University)H-Index: 6
#2Lijun Ma (Wake Forest University)H-Index: 20
Last. Swapan K Das (Wake Forest University)H-Index: 32
view all 7 authors...
Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study
13 CitationsSource
#1Lijun Ma (Wake Forest University)H-Index: 20
#2Ashis K. Mondal (Wake Forest University)H-Index: 11
Last. Barry I. Freedman (Wake Forest University)H-Index: 72
view all 14 authors...
Background: Acetyl Coenzyme A carboxylase beta (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Systematic human studies have not been performed to evaluate whether ACACB variants regulate gene expression and insulin sensitivity in skeletal muscle and adipose tissues. We sought to determine whether ACACB transcribed variants were associated with ACACB gene expression and insulin sensitivity in ...
11 CitationsSource
#1Swapan K Das (Wake Forest University)H-Index: 32
#2Neeraj K. Sharma (Wake Forest University)H-Index: 11
Last. Steven C. Elbein (Wake Forest University)H-Index: 8
view all 7 authors...
Context: Obesity is a complex disease that involves both genetic and environmental perturbations to gene networks in adipose tissue and is proposed as a trigger for metabolic sequelae. Objective: We hypothesized that expression of adipose tissue transcripts in gene networks for adaptive response would correlate with the percent fat mass (PFAT) in healthy nondiabetic subjects to maintain metabolic equilibrium and would overlap with genes modulated in response to elevated fatty acid. Design, Setti...
38 CitationsSource
#1Sandra J. Hasstedt (UofU: University of Utah)H-Index: 44
#2Craig L. Hanis (University of Texas Health Science Center at Houston)H-Index: 50
Last. Steven C. Elbein (Wake Forest University)H-Index: 8
view all 4 authors...
The risk of type 2 diabetes (T2D) increases with obesity. One possible explanation is that pleiotropic genes affect risk of both T2D and obesity. To identify pleiotropic genes, we performed bivariate analysis of T2D with waist-hip ratio (WHR) and with body mass index (BMI) in the African American subset of the Genetics of NIDDM (GENNID) sample. Of 12 T2D loci identified through suggestive or higher univariate lod scores, we inferred pleiotropy with obesity for six (chromosomes 1 at 17–19 MB, 2 a...
12 CitationsSource
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