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Jennifer S. Dumbleton
University of Nottingham
4Publications
1H-index
8Citations
Publications 4
Newest
#1Diane J. StevensonH-Index: 3
Last.Christopher J. HawkeyH-Index: 79
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Introduction The Helicobacter Eradication Aspirin Trial (HEAT) is a multicentre, double blind, randomised controlled trial investigating whether Helicobacter pylori eradication reduces the incidence of hospitalisation for peptic ulcer bleeding [1]. Participants are subjects aged over 60, taking low dose aspirin for at least four months at the time of recruitment; all participants were recruited from primary care. H. pylori positive participants were randomised to receive one week active trial tr...
#1Isla S. Mackenzie (Dund.: University of Dundee)H-Index: 24
#2Ian Ford (Robertson Centre for Biostatistics)H-Index: 108
Last.Thomas M. MacDonald (Dund.: University of Dundee)H-Index: 61
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Background Allopurinol is licensed for the prevention of gout. In recent years, several studies have suggested that allopurinol may have beneficial effects on cardiovascular parameters. The ALL-HEART study is a large outcome trial designed to investigate whether allopurinol improves cardiovascular outcomes in patients with ischaemic heart disease[.1 It is a multicentre, controlled, prospective, randomised, open-label, blinded endpoint trial of allopurinol (up to 600 mg daily) versus no treatment...
Source
#1Jennifer S. Dumbleton (University of Nottingham)H-Index: 1
#2Anthony J Avery (University of Nottingham)H-Index: 47
Last.Christopher J. Hawkey (University of Nottingham)H-Index: 79
view all 10 authors...
Introduction Clinical trials measuring the effect of an intervention on clinical outcomes are more influential than those investigating surrogate measures but are costly. We developed methods to reduce costs substantially by using existing data in primary and secondary care systems, to ask whether Helicobacter pylori eradication would reduce the incidence of hospitalisation for ulcer bleeding in aspirin users. Method The Helicobacter Eradication Aspirin Trial (HEAT) is a HTA-funded, CRN-supporte...
Source
#1Jennifer S. Dumbleton (University of Nottingham)H-Index: 1
#2Anthony J Avery (University of Nottingham)H-Index: 47
Last.Christopher J. Hawkey (University of Nottingham)H-Index: 79
view all 11 authors...
Background Clinical trials measuring the effect of an intervention on clinical outcomes are more influential than those investigating surrogate measures but are costly. We developed methods to reduce costs substantially by using existing data in primary care systems, to ask whether Helicobacter pylori eradication would reduce the incidence of hospitalisation for ulcer bleeding in aspirin users.
8 CitationsSource
1