Erez Dror
University of Basel
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Publications 12
#2Erez DrorH-Index: 7
view all 13 authors...
#1Friederike Schulze (University of Basel)H-Index: 4
#2Josua Wehner (University of Basel)
Last. Sophia J. Wiedemann (University of Basel)H-Index: 1
view all 19 authors...
Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the role of inflammation in GDM. We established a mouse model for GDM on the basis of its two major risk factors, obesity and aging. In these GDM mice, we observed increased Interleukin-1β (IL-1β) expression in the uterus and the placenta along with elev...
#1Urszula Brykczynska (ETH Zurich)
#2Marco Geigges (ETH Zurich)H-Index: 1
Last. Renato Paro (University of Basel)H-Index: 27
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Summary The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-nutrition leads to low-grade systemic inflammation. Here, we investigate tissue-resident components of the innate immune system (macrophages) and their response to short- and long-term nutritional challenges. We analyze the transcriptomes of six tissu...
#1Marianne Böni-Schnetzler (University of Basel)H-Index: 18
#2Stéphanie P. Häuselmann (University of Basel)H-Index: 5
Last. Marc Y. Donath (University of Basel)H-Index: 61
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Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
10 CitationsSource
#1Thierry M. Nordmann (University of Basel)H-Index: 3
#2Erez Dror (University of Basel)H-Index: 7
Last. Marc Y. Donath (University of Basel)H-Index: 61
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Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of inflammation on β-cell identity in T2D has not been studied. Therefore, we investigated whether pro-inflammatory cytokines induce β-cell dedifferentiation and whether anti-inflammatory treatments improve insulin secretion via β-cell redifferentiation. We observed that IL-1β, IL-6 and TNFα promote β-cell dedifferenti...
23 CitationsSource
#1Elise Dalmas (University of Basel)H-Index: 8
#2Frank M. Lehmann (University of Basel)H-Index: 2
Last. Marc Y. Donath (University of Basel)H-Index: 61
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Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
28 CitationsSource
#1Shuyang Traub (University of Basel)H-Index: 5
#2Daniel T. Meier (University of Basel)H-Index: 2
Last. Marc Y. Donath (University of Basel)H-Index: 61
view all 14 authors...
Summary Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α cell ablation and with α cell-specific GLP-1 deficiency. Normally, intestinal GLP-1 compensates for the lack of α cell-derived GLP-1. However, upon aging and metabolic stre...
28 CitationsSource
#1Erez DrorH-Index: 7
#2Elise DalmasH-Index: 8
Last. Marc Y. DonathH-Index: 61
view all 20 authors...
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
70 CitationsSource
#1Katharina Timper (University of Basel)H-Index: 13
#2Elise Dalmas (University of Basel)H-Index: 8
Last. Marc Y. Donath (University of Basel)H-Index: 61
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Background & Aims Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and α cells, leading to secretion of insulin from β cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. Methods We obtained samples of human pancreatic islets and isolated islets from mice; human α cells and β cells were sorted by flow cytometry and incubated with GIP. Islets were analyze...
30 CitationsSource
#1Katharina TimperH-Index: 13
#2Elise DalmasH-Index: 8
Last. Marc Y. DonathH-Index: 61
view all 12 authors...
1 CitationsSource