Icons / Logo / Facebook Created with Sketch. Icons / Logo / Google Created with Sketch. Icons / Logo / ORCID Created with Sketch. Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!
Erez Dror
University of Basel
9Publications
7H-index
172Citations
Publications 9
Newest
Published on Feb 1, 2018in Cell Reports 7.82
Marianne Böni-Schnetzler21
Estimated H-index: 21
(University of Basel),
Stéphanie P. Häuselmann5
Estimated H-index: 5
(University of Basel)
+ 10 AuthorsPraxedis Martin10
Estimated H-index: 10
Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
Published on Dec 1, 2017in Scientific Reports 4.01
Thierry M. Nordmann3
Estimated H-index: 3
(University of Basel),
Erez Dror7
Estimated H-index: 7
(University of Basel)
+ 5 AuthorsMarc Y. Donath57
Estimated H-index: 57
(University of Basel)
Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of inflammation on β-cell identity in T2D has not been studied. Therefore, we investigated whether pro-inflammatory cytokines induce β-cell dedifferentiation and whether anti-inflammatory treatments improve insulin secretion via β-cell redifferentiation. We observed that IL-1β, IL-6 and TNFα promote β-cell dedifferenti...
Published on Nov 1, 2017in Immunity 21.52
Elise Dalmas7
Estimated H-index: 7
(University of Basel),
Frank M. Lehmann2
Estimated H-index: 2
(University of Basel)
+ 18 AuthorsDianne H. Dapito2
Estimated H-index: 2
(ETH Zurich)
Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
Published on Mar 1, 2017in Nature Immunology 23.53
Erez Dror7
Estimated H-index: 7
,
Elise Dalmas7
Estimated H-index: 7
+ 17 AuthorsFriederike Schulze4
Estimated H-index: 4
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
Published on Mar 1, 2017in Cell Reports 7.82
Shuyang Traub5
Estimated H-index: 5
(University of Basel),
Daniel T. Meier2
Estimated H-index: 2
(University of Basel)
+ 11 AuthorsValmir Makshana1
Estimated H-index: 1
(University of Basel)
Summary Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α cell ablation and with α cell-specific GLP-1 deficiency. Normally, intestinal GLP-1 compensates for the lack of α cell-derived GLP-1. However, upon aging and metabolic stre...
Published on Jul 1, 2016in Gastroenterology 19.23
Katharina Timper14
Estimated H-index: 14
(University of Basel),
Elise Dalmas7
Estimated H-index: 7
(University of Basel)
+ 9 AuthorsJulie Kerr-Conte39
Estimated H-index: 39
(university of lille)
Background & Aims Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and α cells, leading to secretion of insulin from β cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. Methods We obtained samples of human pancreatic islets and isolated islets from mice; human α cells and β cells were sorted by flow cytometry and incubated with GIP. Islets were analyze...
Published on Jan 1, 2016
Katharina Timper14
Estimated H-index: 14
,
Elise Dalmas7
Estimated H-index: 7
+ 9 AuthorsJulie Kerr-Conte39
Estimated H-index: 39
BACKGROUND & AIMS: Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and a cells, leading to secretion of insulin from b cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. METHODS: We obtained samples of human pancreatic islets and isolated islets from mice; human a cells and b cells were sorted by flow cytometry and incubated with GIP. Islets were analy...
Published on Apr 1, 2015in Diabetes 7.20
Nadine S. Sauter14
Estimated H-index: 14
(University of Basel),
Constanze Thienel5
Estimated H-index: 5
(University of Basel)
+ 10 AuthorsJulie Kerr-Conte39
Estimated H-index: 39
(university of lille)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin secretion. However, the direct effects of angiotensin II on islet function and underlying mechanisms independent of changes in blood pressure remain unclear. Here we show that exposure of human and mouse islets to angiotensin II induces interleukin...
1