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Erez Dror
University of Basel
9Publications
7H-index
217Citations
Publications 10
Newest
#1Urszula Brykczynska (ETH Zurich)
#2Marco Geigges (ETH Zurich)H-Index: 1
Last.Renato Paro (University of Basel)H-Index: 27
view all 8 authors...
Summary The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-nutrition leads to low-grade systemic inflammation. Here, we investigate tissue-resident components of the innate immune system (macrophages) and their response to short- and long-term nutritional challenges. We analyze the transcriptomes of six tissu...
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#1Marianne Böni-Schnetzler (University of Basel)H-Index: 18
#2Stéphanie P. Häuselmann (University of Basel)H-Index: 5
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 13 authors...
Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
10 CitationsSource
#1Thierry M. Nordmann (University of Basel)H-Index: 3
#2Erez Dror (University of Basel)H-Index: 7
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 8 authors...
Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of inflammation on β-cell identity in T2D has not been studied. Therefore, we investigated whether pro-inflammatory cytokines induce β-cell dedifferentiation and whether anti-inflammatory treatments improve insulin secretion via β-cell redifferentiation. We observed that IL-1β, IL-6 and TNFα promote β-cell dedifferenti...
23 CitationsSource
#1Elise Dalmas (University of Basel)H-Index: 8
#2Frank M. Lehmann (University of Basel)H-Index: 2
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 21 authors...
Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
28 CitationsSource
#1Erez DrorH-Index: 7
#2Elise DalmasH-Index: 8
Last.Marc Y. DonathH-Index: 60
view all 20 authors...
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
70 CitationsSource
#1Shuyang Traub (University of Basel)H-Index: 5
#2Daniel T. Meier (University of Basel)H-Index: 2
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 14 authors...
Summary Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α cell ablation and with α cell-specific GLP-1 deficiency. Normally, intestinal GLP-1 compensates for the lack of α cell-derived GLP-1. However, upon aging and metabolic stre...
28 CitationsSource
#1Katharina Timper (University of Basel)H-Index: 12
#2Elise Dalmas (University of Basel)H-Index: 8
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 12 authors...
Background & Aims Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and α cells, leading to secretion of insulin from β cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. Methods We obtained samples of human pancreatic islets and isolated islets from mice; human α cells and β cells were sorted by flow cytometry and incubated with GIP. Islets were analyze...
30 CitationsSource
#1Katharina TimperH-Index: 12
#2Elise DalmasH-Index: 8
Last.Marc Y. DonathH-Index: 60
view all 12 authors...
1 CitationsSource
#1Katharina TimperH-Index: 12
#2Elise DalmasH-Index: 8
Last.Marc Y. DonathH-Index: 60
view all 12 authors...
BACKGROUND & AIMS: Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and a cells, leading to secretion of insulin from b cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. METHODS: We obtained samples of human pancreatic islets and isolated islets from mice; human a cells and b cells were sorted by flow cytometry and incubated with GIP. Islets were analy...
1 Citations
#1Nadine S. Sauter (University of Basel)H-Index: 14
#2Constanze Thienel (University of Basel)H-Index: 5
Last.Marc Y. Donath (University of Basel)H-Index: 60
view all 13 authors...
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin secretion. However, the direct effects of angiotensin II on islet function and underlying mechanisms independent of changes in blood pressure remain unclear. Here we show that exposure of human and mouse islets to angiotensin II induces interleukin...
26 CitationsSource
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