Match!
Constanze Thienel
University of Basel
EndocrinologyIsletInsulinPancreatic isletsInterleukin
7Publications
5H-index
166Citations
What is this?
Publications 8
Newest
#1Friederike Schulze (University of Basel)H-Index: 4
#2Josua Wehner (University of Basel)
Last. Sophia J. Wiedemann (University of Basel)
view all 19 authors...
Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the role of inflammation in GDM. We established a mouse model for GDM on the basis of its two major risk factors, obesity and aging. In these GDM mice, we observed increased Interleukin-1β (IL-1β) expression in the uterus and the placenta along with elev...
Source
#1Marianne Böni-Schnetzler (University of Basel)H-Index: 18
#2Stéphanie P. Häuselmann (University of Basel)H-Index: 5
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 13 authors...
Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
10 CitationsSource
#1Elise Dalmas (University of Basel)H-Index: 8
#2Frank M. Lehmann (University of Basel)H-Index: 2
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 21 authors...
Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
28 CitationsSource
#1Erez DrorH-Index: 7
#2Elise DalmasH-Index: 8
Last. Marc Y. DonathH-Index: 60
view all 20 authors...
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
70 CitationsSource
#1Katharina Timper (University of Basel)H-Index: 12
#2Elise Dalmas (University of Basel)H-Index: 8
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 12 authors...
Background & Aims Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and α cells, leading to secretion of insulin from β cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. Methods We obtained samples of human pancreatic islets and isolated islets from mice; human α cells and β cells were sorted by flow cytometry and incubated with GIP. Islets were analyze...
30 CitationsSource
#1Katharina TimperH-Index: 12
#2Elise DalmasH-Index: 8
Last. Marc Y. DonathH-Index: 60
view all 12 authors...
1 CitationsSource
#1Katharina TimperH-Index: 12
#2Elise DalmasH-Index: 8
Last. Marc Y. DonathH-Index: 60
view all 12 authors...
BACKGROUND & AIMS: Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and a cells, leading to secretion of insulin from b cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. METHODS: We obtained samples of human pancreatic islets and isolated islets from mice; human a cells and b cells were sorted by flow cytometry and incubated with GIP. Islets were analy...
1 Citations
#1Nadine S. Sauter (University of Basel)H-Index: 14
#2Constanze Thienel (University of Basel)H-Index: 5
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 13 authors...
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin secretion. However, the direct effects of angiotensin II on islet function and underlying mechanisms independent of changes in blood pressure remain unclear. Here we show that exposure of human and mouse islets to angiotensin II induces interleukin...
26 CitationsSource
1