Roberto Cao-Milán
University of Havana
NanoparticleInorganic chemistryChemistryMesoporous silicaDrug delivery
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Publications 9
#1Francisco J. Peón-Díaz (UH: University of Havana)
#2Claudia Iriarte-Mesa (UH: University of Havana)
Last. Roberto Cao-Milán (UH: University of Havana)H-Index: 4
view all 3 authors...
Abstract Drug photodelivery systems are emerging as useful tools for the development of new cancer chemotherapies with reduced side effects. In this context the development of nanodevices that utilize biodegradable components are especially appealing to reduce the accumulation of exogenous materials in important organs. Here we present the development of a nanocomposite comprising copper sulfide nanoparticles (CuSNPs) covered with human serum albumin (HSA) for transporting and photorelease doxor...
#1Andy Hernández-Montoto (Polytechnic University of Valencia)
#2Mónica Gorbe (Polytechnic University of Valencia)H-Index: 5
Last. Félix SancenónH-Index: 42
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Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorption photo-dissociation process.
#1Andy Hernández Montoto (Polytechnic University of Valencia)H-Index: 1
#2Antoni Llopis-Lorente (Polytechnic University of Valencia)H-Index: 5
Last. Félix SancenónH-Index: 42
view all 13 authors...
1 CitationsSource
#1Andy Hernández Montoto (Polytechnic University of Valencia)H-Index: 1
#2Roberto Montes (Polytechnic University of Valencia)H-Index: 1
Last. Ramón Martínez-MáñezH-Index: 59
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Herein, a novel drug photorelease system based on gold nanostars (AuNSts), coated with a mesoporous silica shell and capped with paraffin as thermosensitive molecular gate, is reported. Direct measurements of the surface temperature of a single gold nanostar irradiated using a tightly focused laser beam are performed via a heat-sensitive biological matrix. The surface temperature of a AuNSt increases by hundreds of degrees (°C) even at low laser powers. AuNSts coated with a mesoporous silica she...
8 CitationsSource
#1Tatjana RepenkoH-Index: 5
#2Anne Rix (RWTH Aachen University)H-Index: 12
Last. Alexander J. C. KuehneH-Index: 17
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12 CitationsSource
#1Estefani P. Simão (UFPE: Federal University of Pernambuco)H-Index: 2
#2Roberto Cao-Milán (UH: University of Havana)H-Index: 4
Last. Cesar A.S. Andrade (UFPE: Federal University of Pernambuco)H-Index: 17
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A label free impedimetric aptasensor for simple, fast and reusable picomolar detections of Ochratoxin A (OTA) in grape juices was designed. Two main factors were observed to affect the accurate detections of the toxin: i-lateral interactions between self-assembled aptamers ii- adsorption of large molecules present in complex matrixes like grape juices. Lateral interactions between aptamers were minimized by constructing the aptasensor in a Layer-by-Layer procedure. The interferences associated t...
1 CitationsSource
#1A. Rodríguez-Serradet (UH: University of Havana)H-Index: 1
#2Sibel CiftciH-Index: 2
Last. Roberto Cao-Milán (UH: University of Havana)H-Index: 4
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Precise assembly of exfoliated graphene sheets on electrode surfaces plays a major role for next generation electrodes to be used in sensors, batteries, fuel cells, supercapacitors and other types of energy storage devices. Here, we achieve vertical assembly of sulfonated, few-layer graphene on a metal surface. The few layer graphene flakes were extensively decorated with dopamine capped iron oxide nanoparticles utilizing electrostatic interactions between the nanoparticles and the graphene shee...
1 CitationsSource
#1Javier A. Martínez (UH: University of Havana)H-Index: 3
#2José Valenzuela (UNAM: National Autonomous University of Mexico)H-Index: 2
Last. M.P. Hernández (UH: University of Havana)H-Index: 4
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Abstract Sulfur adlayers on Au(1 1 1) were obtained after the interaction of a gold substrate with an alkaline solution of piperazine bis(dithiocarbamate) sodium salt. Characterization of the sulfur modified gold surface was performed by means of X-Ray Photoelectron Spectroscopy (XPS), Scanning Tunneling Microscopy (STM) and Density Functional Theory (DFT) calculations. XPS signals indicated the presence of S–Au bonds, monomeric and polymeric sulfur, and absence of nitrogen and sodium. Images fr...
4 CitationsSource
#1Roberto Cao-Milán (UH: University of Havana)H-Index: 4
#2Luis M. Liz-Marzán (Ikerbasque)H-Index: 100
Introduction: Gold nanoparticles display a unique combination of chemical inertness, surface chemistry and size- and shape-dependent electronic and optical properties, which render them ideal for clinical applications. Areas covered: The present article describes recent advancements on the application of gold nanoparticles in vaccine development and gene therapy, with augmented efficiencies in cell uptake, specific binding to bioreceptors in cells, protection of conjugated biomolecules and so fo...
70 CitationsSource