Johan Svensson
Lund University
EndocrinologyX chromosomeThyroidMedicineImmune system
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Publications 14
#1Luis Sarmiento (Lund University)H-Index: 11
#2Johan Svensson (Lund University)H-Index: 10
Last. Corrado M. Cilio (Lund University)H-Index: 34
view all 5 authors...
The number of the X chromosome–linked genes has been previously suggested to influence immune responses and the development of autoimmune diseases. In the present study, we aimed at evaluating the level of expression of CD40L (an X-linked gene involved in adaptive immunity) and TLR7 (an X-linked gene involved in innate immunity) in a variety of different karyotypes. Those included males, females and patients with X chromosome aneuploidy. Healthy females (46, XX; n = 10) and healthy males (46, XY...
#2Magnus Becker (Lund University)H-Index: 12
Last. Henry Svensson (Lund University)H-Index: 24
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Malmo and Uppsala have been regional centres for the treatment of cleft lip and palate since the beginning of the 1950s. We have about 80 new cases every year and most patients have conventional oronasal clefts, either cleft lip and palate or isolated cleft palate. During a 10-year period we have come across four patients who have had varying degrees of midface dysplasia combined with intracranial anomalies. One child died at an early age, but the other three children were given medical substitu...
#1Berit Kriström (Umeå University)H-Index: 20
#2A. Stefan AronsonH-Index: 6
Last. Kerstin Albertsson-Wikland (University of Gothenburg)H-Index: 55
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CONTEXT: Weight-based GH dosing results in a wide variation in growth response in children with GH deficiency (GHD) or idiopathic short stature (ISS). OBJECTIVE: The hypothesis tested was whether i ...
64 CitationsSource
#2Johan Svensson (Malmö University)H-Index: 10
Last. Corrado M. CilioH-Index: 34
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#1Jurgen Jansen (EUR: Erasmus University Rotterdam)H-Index: 13
#2Edith C. H. Friesema (EUR: Erasmus University Rotterdam)H-Index: 20
Last. Theo J. Visser (EUR: Erasmus University Rotterdam)H-Index: 89
view all 16 authors...
Context: T-3 action in neurons is essential for brain development. Recent evidence indicates that monocarboxylate transporter 8 (MCT8) is important for neuronal T-3 uptake. Hemizygous mutations have been identified in the X-linked MCT8 gene in boys with severe psychomotor retardation and elevated serum T-3 levels. Objective: The objective of this study was to determine the functional consequences of MCT8 mutations regarding transport of T-3. Design: MCT8 function was studied in wild-type or muta...
63 CitationsSource
#1Barbro HolmH-Index: 2
#2Johan Svensson (Malmö University)H-Index: 10
Last. Corrado M. Cilio (Malmö University)H-Index: 34
view all 9 authors...
Summary Maternal transmission of islet autoantibodies to children born to mothers with type 1 diabetes (T1D) has been shown to protect from autoantibodies and diabetes development later in life. However, the factors conferring disease protection are poorly understood. The aim of this study was to evaluate comparatively proinflammatory cytokines, autoantibodies and lymphocyte subsets in cord blood (CB) of children born to mothers with either T1D (n = 13), gestational diabetes (GDM) (n = 32) or he...
16 CitationsSource
#1Johan Svensson (Lund University)H-Index: 10
#2Christer AnderssonH-Index: 1
Last. Leif Bülow (Lund University)H-Index: 34
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Amelogenin is a dental enamel matrix protein involved in formation of dental enamel. In this study, we have expressed two different recombinant murine amelogenins in Escherichia coli: the untagged rM179, and the histidine tagged rp(H)M180, identical to rM179 except that it carries the additional N-terminal sequence MRGSHHHHHHGS. The effects of the histidine tag on expression levels, and on growth properties of the amelogenin expressing cells were studied. Purification of a crude protein extract ...
41 CitationsSource
#1Johan Svensson (Lund University)H-Index: 10
#2Anne BjörnståhlH-Index: 1
Last. Sten-A. Ivarsson (Lund University)H-Index: 21
view all 3 authors...
41 CitationsSource
#1Edith C. H. Friesema (EUR: Erasmus University Rotterdam)H-Index: 20
#2Annette Grueters (Humboldt University of Berlin)H-Index: 2
Last. Theo J. Visser (EUR: Erasmus University Rotterdam)H-Index: 89
view all 17 authors...
Summary Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transporter, the gene of which is located on the X chromosome. We tested whether mutations in MCT8 cause severe psychomotor retardation and high serum triiodothyronine (T 3 ) concentrations in five unrelated young boys. The coding sequence of MCT8 was analysed by PCR and direct sequencing of its six exons. In two patients, gene deletions of 2·4 kb and 24 kb were recorded and in three patients missense mutations Ala150Val, Arg171st...
463 CitationsSource
#1Johan SvenssonH-Index: 10
#2Paul E NilssonH-Index: 5
Last. Sten-A. IvarssonH-Index: 21
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The use of thyroid ultrasonography for determination of thyroid volume requires reliable reference criteria. The current World Health Organization/International Council for the Control of Iodine Deficiency Disorders (WHO/ICCIDD) reference has been questioned since iodine-sufficient children have been found throughout the world with distinctly smaller thyroid volumes. A difference in part explained by a systematic bias when generating the WHO/ICCIDD reference data. The objective with this study w...
15 CitationsSource