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Alexey Mishin
Moscow Institute of Physics and Technology
13Publications
5H-index
77Citations
Publications 13
Newest
#1A. P. Luginina (MIPT: Moscow Institute of Physics and Technology)
#2Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)
Last.Elizaveta Lyapina (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
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The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT1R antagonists are widely prescribed as antiasthmatic drugs; however, these drugs demonstrate low effectiveness in some patients and exhibit a variety of side effects. To gain deeper understanding into the functional mechanisms of CysLTRs, we determined the crystal structu...
#1Alexey Mishin (MIPT: Moscow Institute of Physics and Technology)H-Index: 5
#2Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)
Last.Vadim Cherezov (SC: University of Southern California)H-Index: 60
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ABSTRACTIntroduction: X-ray crystallography has made important contributions to modern drug development but its application to many important drug targets has been extremely challenging. The recent emergence of X-ray free electron lasers (XFELs) and advancements in serial femtosecond crystallography (SFX) have offered new opportunities to overcome limitations of traditional crystallography to accelerate the structure-based drug discovery (SBDD) process.Areas covered: In this review, the authors ...
#1Vera V. Nazarenko (MIPT: Moscow Institute of Physics and Technology)
#2V.V. Nazarenko (MIPT: Moscow Institute of Physics and Technology)
Last.A. V. RogachevH-Index: 6
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Light-Oxygen-Voltage (LOV) domains are conserved parts of photoreceptors in plants, bacteria and fungi that bind flavins as chromophores and detect blue light. In the past, LOV domain variants have been developed as fluorescent reporter proteins (called flavin-based fluorescent proteins; FbFPs), which due to their ability to fluoresce under anaerobic conditions, fast folding kinetics and a small size of ∼12–16 kDa are a promising reporter system for quantitative real-time analysis of biological ...
#1Ivan Maslov (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
#2Andrey O. Bogorodskiy (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last.Valentin I. Gordeliy (MIPT: Moscow Institute of Physics and Technology)H-Index: 21
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Research on halophilic microorganisms is important due to their relation to fundamental questions of survival of living organisms in a hostile environment. Here we introduce a novel method to stain halophiles with MitoTracker fluorescent dyes in their growth medium. The method is based on membrane-potential sensitive dyes, which were originally used to label mitochondria in eukaryotic cells. We demonstrate that these fluorescent dyes provide high staining efficiency and are beneficial for multi-...
#1D. Zabelskii (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
#2A. V. Vlasov (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
Last.A. V. Rogachev (JINR: Joint Institute for Nuclear Research)H-Index: 6
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#1Olga A. Petrova (MSU: Moscow State University)H-Index: 2
#2Alexey B. Mantsyzov (MSU: Moscow State University)H-Index: 6
Last.Alexander N. Malyavko (MSU: Moscow State University)H-Index: 3
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