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PharmacokineticsDrug carrierOral administrationInsulinParacellular transport
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The present dissertation was aimed at evaluating the mechanism, safety and efficacy of novel pH-sensitive nanoparticles (NPs) for the oral delivery of insulin. The self-assembled NPs with pH-responsive characteristics were prepared by mixing the anionic poly-r-glutamic acid solution with the cationic chitosan (CS) solution in the presence of MgSO4 and sodium tripolyphosphate. The absorption enhancing potential of the test NPs was evaluated using an in vitro Caco-2 cell monolayer model. The in vi...
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