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Valentin I. Gordeliy
Moscow Institute of Physics and Technology
148Publications
23H-index
1,718Citations
Publications 148
Newest
#1Dmitry Bratanov (Forschungszentrum Jülich)H-Index: 2
#2K. KovalevH-Index: 5
Last.Valentin I. GordeliyH-Index: 23
view all 29 authors...
Recently, two groups of rhodopsin genes were identified in large double-stranded DNA viruses. The structure and function of viral rhodopsins are unknown. We present functional characterization and high-resolution structure of an Organic Lake Phycodnavirus rhodopsin II (OLPVRII) of group 2. It forms a pentamer, with a symmetrical, bottle-like central channel with the narrow vestibule in the cytoplasmic part covered by a ring of 5 arginines, whereas 5 phenylalanines form a hydrophobic barrier in i...
#1T. B. Feldman (MSU: Moscow State University)H-Index: 7
#2O I Ivankov (JINR: Joint Institute for Nuclear Research)H-Index: 7
Last.Mikhail A. Ostrovsky (MSU: Moscow State University)H-Index: 11
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Abstract The supramolecular organization of the visual pigment rhodopsin in the photoreceptor membrane remains contentious. Specifically, whether this G protein-coupled receptor functions as a monomer or dimer remains unknown, as does the presence or absence of ordered packing of rhodopsin molecules in the photoreceptor membrane. Completely opposite opinions have been expressed on both issues. Herein, using small-angle neutron and X-ray scattering approaches, we performed a comparative analysis ...
#1Aleksandra Luginina (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
#2Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
Last.Vadim Cherezov (SC: University of Southern California)H-Index: 61
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The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT1R antagonists are widely prescribed as antiasthmatic drugs; however, these drugs demonstrate low effectiveness in some patients and exhibit a variety of side effects. To gain deeper understanding into the functional mechanisms of CysLTRs, we determined the crystal structu...
#1K. KovalevH-Index: 5
#2Dmytro Volkov (Forschungszentrum Jülich)
Last.Valentin I. GordeliyH-Index: 23
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Abstract Rhodopsins are the most abundant light-harvesting proteins. A new family of rhodopsins, heliorhodopsins (HeRs), was recently discovered. In opposite to the known rhodopsins their N-termini face the cytoplasm. HeRs structure and function remain unknown. We present structures of two HeR-48C12 states at 1.5 A showing its remarkable difference from all known rhodopsins. Its internal extracellular part is completely hydrophobic, while the cytoplasmic part comprises a cavity (’active site’), ...
#1V.V. Nazarenko (MIPT: Moscow Institute of Physics and Technology)
#2A. Remeeva (MIPT: Moscow Institute of Physics and Technology)H-Index: 3
Last.I. Gushchin (MIPT: Moscow Institute of Physics and Technology)H-Index: 10
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Light-Oxygen-Voltage (LOV) domains are conserved parts of photoreceptors in plants, bacteria and fungi that bind flavins as chromophores and detect blue light. In the past, LOV domain variants have been developed as fluorescent reporter proteins (called flavin-based fluorescent proteins; FbFPs), which due to their ability to fluoresce under anaerobic conditions, fast folding kinetics and a small size of ∼12–16 kDa are a promising reporter system for quantitative real-time analysis of biological ...
#1K. KovalevH-Index: 5
#2Vitaly Polovinkin (CNRS: Centre national de la recherche scientifique)H-Index: 1
Last.Valentin I. Gordeliy (MIPT: Moscow Institute of Physics and Technology)H-Index: 23
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Rhodopsins are the most universal biological light-energy transducers and abundant phototrophic mechanisms that evolved on Earth and have a remarkable diversity and potential for biotechnological applications. Recently, the first sodium-pumping rhodopsin KR2 from Krokinobacter eikastus was discovered and characterized. However, the existing structures of KR2 are contradictory, and the mechanism of Na + pumping is not yet understood. Here, we present a structure of the cationic (non H + ) light-d...
#1Ivan Maslov (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
#2Andrey Bogorodskiy (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last.Valentin Borshchevskiy (MIPT: Moscow Institute of Physics and Technology)H-Index: 11
view all 12 authors...
Research on halophilic microorganisms is important due to their relation to fundamental questions of survival of living organisms in a hostile environment. Here we introduce a novel method to stain halophiles with MitoTracker fluorescent dyes in their growth medium. The method is based on membrane-potential sensitive dyes, which were originally used to label mitochondria in eukaryotic cells. We demonstrate that these fluorescent dyes provide high staining efficiency and are beneficial for multi-...
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