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Lin Tian
Peking University
Single-nucleotide polymorphismNeuroscienceCognitionPopulationSchizophrenia
16Publications
8H-index
167Citations
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Publications 16
Newest
#2Yue CuiH-Index: 14
Last. Hao YanH-Index: 79
view all 8 authors...
Background: Schizophrenia is a neurodevelopmental disorder with high heritability. Widespread cortical thinning has been identified in schizophrenia, suggesting that it is a result of cortical development deficit. However, the findings of other cortical morphological indexes of patients are inconsistent, and the research on their relationship with genetic risk factors for schizophrenia is rare. Methods: In order to investigate cortical morphology deficits and their disease-related genetic liabil...
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#1Na Luo (CAS: Chinese Academy of Sciences)H-Index: 2
#2Lin TianH-Index: 8
Last. Jing Sui (CAS: Chinese Academy of Sciences)H-Index: 31
view all 13 authors...
Abstract The progress of schizophrenia at various stages is an intriguing question, which has been explored to some degree using single-modality brain imaging data, e.g. gray matter (GM) or functional connectivity (FC). However it remains unclear how those changes from different modalities are correlated with each other and if the sensitivity to duration of illness and disease stages across modalities is different. In this work, we jointly analyzed FC, GM volume and single nucleotide polymorphis...
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#1Na Luo (CAS: Chinese Academy of Sciences)H-Index: 2
#2Jing SuiH-Index: 31
Last. Tianzi JiangH-Index: 67
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Abstract Background In the past decades, substantial effort has been made to explore the genetic influence on brain structural/functional abnormalities in schizophrenia, as well as cognitive impairments. In this work, we aimed to extend previous studies to explore the internal mediation pathway among genetic factor, brain features and cognitive scores in a large Chinese dataset. Methods Gray matter (GM) volume, fractional amplitude of low-frequency fluctuations (fALFF), and 4522 schizophrenia-su...
3 CitationsSource
Jul 1, 2018 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Na Luo (CAS: Chinese Academy of Sciences)H-Index: 2
#2Lin TianH-Index: 8
Last. Jing Sui (CAS: Chinese Academy of Sciences)H-Index: 31
view all 9 authors...
Schizophrenia (SZ) is a highly heritable disease exhibiting substantial structural and functional brain impairments. The duration of illness and medication use may cause different presentations of impairments in patients. To understand the progressive variations of the disease, most recent studies have reported brain functional or structural abnormalities associated with illness duration, but a comprehensive study of pathology underlying brain structure, function and illness duration is still li...
1 CitationsSource
#1Linlin QiuH-Index: 2
#2Hao Yan (PKU: Peking University)H-Index: 79
Last. Dai Zhang (PKU: Peking University)H-Index: 28
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Widespread cortical gray matter alternations in people with schizophrenia are correlated with both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye movement (EEM). Particularly, the loss of gray matter density is specifically related to deficits of the responsive search score (RSS) of EEM in schizophrenia. It is unknown, however, whether the schizophrenia-related RSS deficits are associated with certain psychotic symptoms, such as hallucinat...
2 CitationsSource
#1Sisi Jiang (PKU: Peking University)H-Index: 3
#2Hao Yan (PKU: Peking University)H-Index: 79
Last. Dai ZhangH-Index: 28
view all 8 authors...
Background It has been suggested that working memory deficits is a core feature of symptomatology of schizophrenia, which can be detected in patients and their unaffected relatives. The impairment of working memory has been found related to the abnormal activity of human brain regions in many functional magnetic resonance imaging (fMRI) studies. This study investigated how brain region activation was altered in schizophrenia and how it was inherited independently from performance deficits. Metho...
6 CitationsSource
#1Jinmin Liao (PKU: Peking University)H-Index: 3
#2Hao Yan (PKU: Peking University)H-Index: 13
Last. Fei Wang (Yale University)H-Index: 53
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Abstract Background Psychopathy is associated with dysfunction in regions that compose the paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole (TP), parahippocampal gyrus (PHG) and cingulate cortex (CC). However, findings of structural alterations in these regions are inconsistent in schizophrenia, and correlations between paralimbic system measures and symptomatology and cognitive function have not been investigated. Method 93 patients with schizophreni...
13 CitationsSource
#1Hao Yan (PKU: Peking University)H-Index: 13
#2Lin Tian (PKU: Peking University)H-Index: 8
Last. Dai ZhangH-Index: 28
view all 8 authors...
Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their first-degree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connecti...
12 CitationsSource
#1Fuquan Zhang (PKU: Peking University)H-Index: 8
#2Guoqiang WangH-Index: 8
Last. Dai Zhang (PKU: Peking University)H-Index: 28
view all 19 authors...
a b s t r a c t Schizophrenia (SZ) is a severe mental disorder characterized by multiple neurodevelopmental dysfunc- tions including a breakdown of thinking process and a deficit of typical emotional responses. Ataxin-2 (ATXN2) plays vital roles in cell proliferation and growth, and functional mutations of ATXN2 cause neurodegenerative phenotypes, including spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS). To explore the possible role of ATXN2 in SZ, we conducted a tw...
8 CitationsSource
#1Chunhui JinH-Index: 11
#2Cheng-Zhu Wu (Bengbu Medical College)H-Index: 1
Last. Zaohuo ChengH-Index: 11
view all 8 authors...
Abstract It has been reported that a single nucleotide polymorphism (SNP), rs2373115, in the GRB-associated binding protein 2 ( GAB2 ) gene was associated with late-onset AD in Caucasians. Subsequently, other researchers have attempted to validate this finding in different ethnic populations. However, these findings have produced both negative and positive results. To derive a more precise estimation for whether GAB2 polymorphism rs2373115 is associated with sporadic Alzheimer's disease (SAD), w...
2 CitationsSource
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