Jane Crawley
University of Oxford
Intensive care medicineImmunologyMalariaCerebral MalariaMedicine
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Publications 47
#1Elizabeth C George (Medical Research Council)H-Index: 4
#2Sarah Kiguli (MUK: Makerere University)H-Index: 16
Last. A. Sarah Walker (Medical Research Council)H-Index: 17
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African children hospitalised with severe febrile illness have a high risk of mortality. The Fluid Expansion As Supportive Therapy (FEAST) trial (ISCRTN 69856593) demonstrated increased mortality risk associated with fluid boluses, but the temporal relationship to bolus therapy and underlying mechanism remains unclear. In a post hoc retrospective analysis, flexible parametric models were used to compare change in mortality risk post-randomisation in children allocated to bolus therapy with 20–40...
#1Katherine L O'BrienH-Index: 58
#2Henry C. BaggettH-Index: 24
Last. Syed M. A. ZamanH-Index: 20
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Summary Background Pneumonia is the leading cause of death among children younger than 5 years. In this study, we estimated causes of pneumonia in young African and Asian children, using novel analytical methods applied to clinical and microbiological findings. Methods We did a multi-site, international case-control study in nine study sites in seven countries: Bangladesh, The Gambia, Kenya, Mali, South Africa, Thailand, and Zambia. All sites enrolled in the study for 24 months. Cases were child...
9 CitationsSource
#1Jane Crawley (University of Oxford)H-Index: 21
#2Martha Mwangome (Wellcome Trust)H-Index: 11
Last. André Briend (UCPH: University of Copenhagen)H-Index: 24
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#1Claire Marriott Keene (University of Oxford)H-Index: 1
#2Arjen M. Dondorp (University of Oxford)H-Index: 63
Last. Mavuto Mukaka (University of Oxford)H-Index: 19
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2 CitationsSource
#1David R. Murdoch (University of Otago)H-Index: 45
#2Susan C. Morpeth (Kenya Medical Research Institute)H-Index: 20
Last. J. L. MitchellH-Index: 15
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Background. It is standard practice for laboratories to assess the cellular quality of expectorated sputum specimens to check that they originated from the lower respiratory tract. The presence of low numbers of squamous epithelial cells (SECs) and high numbers of polymorphonuclear (PMN) cells are regarded as indicative of a lower respiratory tract specimen. However, these quality ratings have never been evaluated for induced sputum specimens from children with suspected pneumonia. Methods. We e...
12 CitationsSource
#1Daniel R. Feikin (National Center for Immunization and Respiratory Diseases)H-Index: 51
#2Wei Fu (Johns Hopkins University)H-Index: 7
Last. J. L. MitchellH-Index: 15
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Background. The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) of children with pneumonia is unclear. To determine if viral load could provide evidence of causality of pneumonia, we compared viral load in the URT of children with World Health Organization–defined severe and very severe pneumonia and age-matched community controls. Methods. In the 9 developing country sites, nasopharyngeal/oropharyngeal swabs from children with and without pneumonia were tested...
18 CitationsSource
#1Jane Crawley (University of Oxford)H-Index: 21
#2Christine Prosperi (Johns Hopkins University)H-Index: 12
Last. J. Anthony G. Scott (Kenya Medical Research Institute)H-Index: 37
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Variable adherence to standardized case definitions, clinical procedures, specimen collection techniques, and laboratory methods has complicated the interpretation of previous multicenter pneumonia etiology studies. To circumvent these problems, a program of clinical standardization was embedded in the Pneumonia Etiology Research for Child Health (PERCH) study.Between March 2011 and August 2013, standardized training on the PERCH case definition, clinical procedures, and collection of laboratory...
15 CitationsSource
#1Melissa M. Higdon (Johns Hopkins University)H-Index: 11
#2Tham Le (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Shabir A. Madhi (Medical Research Council)H-Index: 12
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textabstractBackground. Lack of a gold standard for identifying bacterial and viral etiologies of pneumonia has limited evaluation of C-reactive protein (CRP) for identifying bacterial pneumonia. We evaluated the sensitivity and specificity of CRP for identifying bacterial vs respiratory syncytial virus (RSV) pneumonia in the Pneumonia Etiology Research for Child Health (PERCH) multicenter case-control study. Methods. We measured serum CRP levels in cases with World Health Organization-defined s...
13 CitationsSource
#1Henry C. Baggett (CDC: Centers for Disease Control and Prevention)H-Index: 24
#2Nora L. WatsonH-Index: 9
Last. J. L. MitchellH-Index: 15
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Previous studies suggested an association between upper airway pneumococcal colonization density and pneumococcal pneumonia, but data in children are limited. Using data from the Pneumonia Etiology Research for Child Health (PERCH) study, we assessed this potential association.PERCH is a case-control study in 7 countries: Bangladesh, The Gambia, Kenya, Mali, South Africa, Thailand, and Zambia. Cases were children aged 1-59 months hospitalized with World Health Organization-defined severe or very...
21 CitationsSource
#1Elizabeth C George (Medical Research Council)H-Index: 4
#2As Walker (Medical Research Council)H-Index: 24
Last. Abdel Babiker (Medical Research Council)H-Index: 39
view all 17 authors...
Mortality in paediatric emergency care units in Africa often occurs within the first 24 h of admission and remains high. Alongside effective triage systems, a practical clinical bedside risk score to identify those at greatest risk could contribute to reducing mortality.
14 CitationsSource