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Marta Barrachina
Bellvitge University Hospital
50Publications
27H-index
2,122Citations
Publications 50
Newest
Published on Sep 1, 2018in Journal of Psychiatric Research3.92
Alex Ferrer2
Estimated H-index: 2
(Bellvitge University Hospital),
Javier Costas21
Estimated H-index: 21
(Grupo México)
+ 12 AuthorsJosé M. Crespo19
Estimated H-index: 19
(University of Barcelona)
Abstract Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) have both been linked to abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. Polymorphisms in the genes involved in HPA axis activity, such as FKBP5 , and their interactions with childhood trauma have been associated with stress-related mental disorders. Our goal was to study the role of FKBP5 genetic variants in HPA axis negative feedback regulation as a possible risk factor for different mental disorde...
Published on Feb 1, 2016in American Journal of Pathology3.76
Marta Blanch3
Estimated H-index: 3
(Bellvitge University Hospital),
Jose Luis Mosquera6
Estimated H-index: 6
(University of Barcelona)
+ 2 AuthorsMarta Barrachina27
Estimated H-index: 27
(Bellvitge University Hospital)
Mitochondrial dysfunction is linked with the etiopathogenesis of Alzheimer disease and Parkinson disease. Mitochondria are intracellular organelles essential for cell viability and are characterized by the presence of the mitochondrial (mt)DNA. DNA methylation is a well-known epigenetic mechanism that regulates nuclear gene transcription. However, mtDNA methylation is not the subject of the same research attention. The present study shows the presence of mitochondrial 5-methylcytosine in CpG and...
Published on Sep 1, 2014in Neurobiology of Disease5.16
Izaskun Villar-Menéndez5
Estimated H-index: 5
(Bellvitge University Hospital),
Sílvia Porta1
Estimated H-index: 1
(Bellvitge University Hospital)
+ 6 AuthorsMarta Barrachina27
Estimated H-index: 27
(Bellvitge University Hospital)
Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that stimulates adenylyl cyclase activity. In the brain, A 2A Rs are found highly enriched in striatal GABAergic medium spiny neurons, related to the control of voluntary movement. Pharmacological modulation of A 2A Rs is particularly useful in Parkinson’s disease (PD) due to their property of antagonizing dopamine D 2 receptor activity. Increases in A 2A R levels have been described in PD patients showing an important los...
Published on Sep 1, 2014in Purinergic Signalling3.04
Izaskun Villar-Menéndez5
Estimated H-index: 5
(Bellvitge University Hospital),
Fabiana Núñez3
Estimated H-index: 3
(University of Barcelona)
+ 7 AuthorsMarta Barrachina27
Estimated H-index: 27
(Bellvitge University Hospital)
Adenosine A2A receptor (A2AR) is a G protein-coupled receptor enriched in the striatum for which an increased expression has been demonstrated in certain neurological diseases. Interestingly, previous in vitro studies demonstrated that A2AR expression levels are reduced after treatment with S-adenosyl-L-methionine (SAM), a methyl donor molecule involved in the methylation of important biological structures such as DNA, proteins, and lipids. However, the in vivo effects of SAM treatment on A2AR e...
Published on Apr 1, 2014in Journal of Psychiatric Research3.92
Izaskun Villar-Menéndez5
Estimated H-index: 5
(Bellvitge University Hospital),
Sara Díaz-Sánchez3
Estimated H-index: 3
(UCLM: University of Castilla–La Mancha)
+ 7 AuthorsMarta Barrachina27
Estimated H-index: 27
(Bellvitge University Hospital)
Abstract Schizophrenia (SZ) is a mental disorder of unknown origin. Some scientific evidence seems to indicate that SZ is not a single disease entity, since there are patient groups with clear symptomatic, course and biomarker differences. SZ is characterized by a hyperdopaminergic state related to high dopamine D 2 receptor activity. It has also been proposed that there is a hypoadenosynergic state. Adenosine is a nucleoside widely distributed in the organism with neuromodulative and neuroprote...
Published on Dec 1, 2013in Purinergic Signalling3.04
Elisabet Aliagas6
Estimated H-index: 6
(University of Barcelona),
Izaskun Villar-Menéndez5
Estimated H-index: 5
(Bellvitge University Hospital)
+ 5 AuthorsMarta Barrachina27
Estimated H-index: 27
(Bellvitge University Hospital)
Schizophrenia (SZ) is a major chronic neuropsychiatric disorder characterized by a hyperdopaminergic state. The hypoadenosinergic hypothesis proposes that reduced extracellular adenosine levels contribute to dopamine D2 receptor hyperactivity. ATP, through the action of ecto-nucleotidases, constitutes a main source of extracellular adenosine. In the present study, we examined the activity of ecto-nucleotidases (NTPDases, ecto-5′-nucleotidase, and alkaline phosphatase) in the postmortem putamen o...
Published on Jun 1, 2013in Neuromolecular Medicine2.58
Izaskun Villar-Menéndez5
Estimated H-index: 5
,
Marta Blanch3
Estimated H-index: 3
+ 6 AuthorsMarta Barrachina27
Estimated H-index: 27
Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington’s disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight into the molecular mechanisms that regulate A2AR gene (ADORA2A) expression in HD. Based on previous data reported by our group, we measured the methylcytosine (5mC) and hydroxymethy...
Published on Jan 1, 2013
Antonio Celada41
Estimated H-index: 41
,
Concepció Soler23
Estimated H-index: 23
+ 1 AuthorsMarta Barrachina27
Estimated H-index: 27
and Antonio CeladaHerrero, Eduard Gonalons, Concepcio Soler, Jorge Lloberas Jordi Xaus, Monica Comalada, Marta Barrachina, Carmenhttp://www.jimmunol.org/content/165/11/6364J Immunol€2000; 165:6364-6371; ;Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new article...
Published on Dec 1, 2012in Cell and Tissue Banking1.94
Marta Barrachina27
Estimated H-index: 27
(Bellvitge University Hospital),
Jesús Moreno9
Estimated H-index: 9
(Bellvitge University Hospital)
+ 2 AuthorsIsidre Ferrer72
Estimated H-index: 72
(University of Barcelona)
Histone acetylation plays a role in the regulation of gene transcription. Yet it is not known whether post-mortem brain tissue is suitable for the analysis of histone acetylation. To examine this question, nucleosomes were isolated from frontal cortex of nine subjects which were obtained at short times after death and immediately frozen at −80°C or maintained at room temperature from 3 h up to 50 h after death and then frozen at −80°C to mimic variable post-mortem delay in tissue processing as c...
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