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Marta Barrachina
Carlos III Health Institute
53Publications
28H-index
2,213Citations
Publications 52
Newest
#1Alex Ferrer (Bellvitge University Hospital)H-Index: 3
#2Javier Labad (Autonomous University of Barcelona)H-Index: 23
Last.Virginia Soria (University of Barcelona)H-Index: 11
view all 12 authors...
Brain-derived neurotrophic factor (BDNF) gene regulation has been linked to the pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits, and altered BDNF regulation has a relevant role in neurocognitive functions. Our goal was to explore the association between BDNF genetic and epigenetic variations with neurocognitive performance in a group of MDD patients and healthy controls considering possible modulating factors. The sample included 134 subjects, 64 MDD pati...
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#1Alex Ferrer (Bellvitge University Hospital)H-Index: 3
#2Javier Costas (Grupo México)H-Index: 24
Last.Virginia Soria (University of Barcelona)H-Index: 11
view all 15 authors...
Abstract Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) have both been linked to abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. Polymorphisms in the genes involved in HPA axis activity, such as FKBP5, and their interactions with childhood trauma have been associated with stress-related mental disorders. Our goal was to study the role of FKBP5 genetic variants in HPA axis negative feedback regulation as a possible risk factor for different mental disorder...
4 CitationsSource
#1Marta Blanch (Bellvitge University Hospital)H-Index: 3
#2Jose Luis Mosquera (University of Barcelona)H-Index: 7
Last.Marta Barrachina (Bellvitge University Hospital)H-Index: 28
view all 5 authors...
Mitochondrial dysfunction is linked with the etiopathogenesis of Alzheimer disease and Parkinson disease. Mitochondria are intracellular organelles essential for cell viability and are characterized by the presence of the mitochondrial (mt)DNA. DNA methylation is a well-known epigenetic mechanism that regulates nuclear gene transcription. However, mtDNA methylation is not the subject of the same research attention. The present study shows the presence of mitochondrial 5-methylcytosine in CpG and...
40 CitationsSource
#1Izaskun Villar-Menéndez (Bellvitge University Hospital)H-Index: 5
#2Sílvia Porta (Bellvitge University Hospital)H-Index: 1
Last.Marta Barrachina (Bellvitge University Hospital)H-Index: 28
view all 9 authors...
Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that stimulates adenylyl cyclase activity. In the brain, A 2A Rs are found highly enriched in striatal GABAergic medium spiny neurons, related to the control of voluntary movement. Pharmacological modulation of A 2A Rs is particularly useful in Parkinson’s disease (PD) due to their property of antagonizing dopamine D 2 receptor activity. Increases in A 2A R levels have been described in PD patients showing an important los...
48 CitationsSource
#1Izaskun Villar-Menéndez (Bellvitge University Hospital)H-Index: 5
#2Fabiana Núñez (University of Barcelona)H-Index: 4
Last.Marta Barrachina (Bellvitge University Hospital)H-Index: 28
view all 10 authors...
Adenosine A2A receptor (A2AR) is a G protein-coupled receptor enriched in the striatum for which an increased expression has been demonstrated in certain neurological diseases. Interestingly, previous in vitro studies demonstrated that A2AR expression levels are reduced after treatment with S-adenosyl-L-methionine (SAM), a methyl donor molecule involved in the methylation of important biological structures such as DNA, proteins, and lipids. However, the in vivo effects of SAM treatment on A2AR e...
4 CitationsSource
#1Izaskun Villar-Menéndez (Bellvitge University Hospital)H-Index: 5
#2Sara Díaz-Sánchez (UCLM: University of Castilla–La Mancha)H-Index: 3
Last.Marta Barrachina (Bellvitge University Hospital)H-Index: 28
view all 10 authors...
Abstract Schizophrenia (SZ) is a mental disorder of unknown origin. Some scientific evidence seems to indicate that SZ is not a single disease entity, since there are patient groups with clear symptomatic, course and biomarker differences. SZ is characterized by a hyperdopaminergic state related to high dopamine D 2 receptor activity. It has also been proposed that there is a hypoadenosynergic state. Adenosine is a nucleoside widely distributed in the organism with neuromodulative and neuroprote...
21 CitationsSource
#1Elisabet Aliagas (University of Barcelona)H-Index: 6
#2Izaskun Villar-Menéndez (Bellvitge University Hospital)H-Index: 5
Last.Marta Barrachina (Bellvitge University Hospital)H-Index: 28
view all 8 authors...
Schizophrenia (SZ) is a major chronic neuropsychiatric disorder characterized by a hyperdopaminergic state. The hypoadenosinergic hypothesis proposes that reduced extracellular adenosine levels contribute to dopamine D2 receptor hyperactivity. ATP, through the action of ecto-nucleotidases, constitutes a main source of extracellular adenosine. In the present study, we examined the activity of ecto-nucleotidases (NTPDases, ecto-5′-nucleotidase, and alkaline phosphatase) in the postmortem putamen o...
13 CitationsSource
Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington’s disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight into the molecular mechanisms that regulate A2AR gene (ADORA2A) expression in HD. Based on previous data reported by our group, we measured the methylcytosine (5mC) and hydroxymethy...
75 CitationsSource
#1Antonio CeladaH-Index: 42
#2Concepció SolerH-Index: 23
Last.Marta BarrachinaH-Index: 28
view all 4 authors...
and Antonio CeladaHerrero, Eduard Gonalons, Concepcio Soler, Jorge Lloberas Jordi Xaus, Monica Comalada, Marta Barrachina, Carmenhttp://www.jimmunol.org/content/165/11/6364J Immunol€2000; 165:6364-6371; ;Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new article...
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