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Ana Luisa Escapa
University of the Algarve
HeLaCeratonia siliquaBiochemistryBotanyBiology
9Publications
6H-index
116Citations
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Publications 9
Newest
#1João Charneca (University of the Algarve)H-Index: 1
#2Ana Matias (University of the Algarve)H-Index: 18
Last. José Bragança (University of the Algarve)H-Index: 16
view all 8 authors...
Abstract Cited2 plays crucial roles in mouse embryonic stem cells self-renewal, the initiation of the somatic reprogramming process into induced pluripotent stem cells (iPSC) and the suppression of cell senescence. Here, we investigated the potential of CITED2 expression in combination with the Oct4, Sox2, Klf4 and c-Myc factors for reprogramming of primary mouse embryonic fibroblasts (MEF) at passage 2 and 4. The ectopic CITED2 expression in primary MEF prior to the onset of the reprogramming p...
1 CitationsSource
#1Kamil R. Kranc (Edin.: University of Edinburgh)H-Index: 15
#2Daniel V. OliveiraH-Index: 5
Last. José Bragança (University of the Algarve)H-Index: 16
view all 13 authors...
Identifying novel players of the pluripotency gene regulatory network centered on Oct4, Sox2, and Nanog as well as delineating the interactions within the complex network is key to understanding self-renewal and early cell fate commitment of embryonic stem cells (ESC). While overexpression of the transcriptional regulator Cited2 sustains ESC pluripotency, its role in ESC functions remains unclear. Here, we show that Cited2 is important for proliferation, survival, and self-renewal of mouse ESC. ...
14 CitationsSource
Extracts from fruit pulps of six female cultivars and two hermaphrodite Portuguese carob trees [(Ceratonia siliqua L., Fabaceae)] exhibited strong antioxidant activity and were rich in phenolic compounds. The extracts decreased the viability of different human cancer cell lines on a dose- and time-dependent manner. Gender and cultivar significantly influenced the chemical content and the biological activities of the extracts. Extracts from hermaphrodite trees had a higher content of phenolic com...
34 CitationsSource
#1Luísa Custódio (University of the Algarve)H-Index: 18
#2Ana Luisa Escapa (University of the Algarve)H-Index: 6
Last. Anabela Romano (University of the Algarve)H-Index: 23
view all 9 authors...
This work aimed to evaluate the phytochemical content and to determine the antioxidant and cytotoxic activities of methanol extracts of the carob tree (Ceratonia siliqua L.) germ flour. The extracts were rich in phenolic compounds, had considerable antioxidant activity, and reduced the viability of cervical (HeLa) cancer cells. The chemical content and the biological activities of the extracts were significantly affected by gender and cultivar. Female cultivar Galhosa had the highest levels of p...
30 CitationsSource
#1Luísa CustódioH-Index: 18
#2Ana Luisa EscapaH-Index: 6
Last. Anabela RomanoH-Index: 23
view all 9 authors...
This research evaluated the in vitro apoptotic inducing properties of a methanol leaf extract of carob tree ( Ceratonia siliqua L.) on a human cervical adenocarcinoma cell line (HeLa). The cell viability effect on a prostate (DU-145), breast (MDA-MB-231) and colon cell line (HCT-166) was also assessed. The effect of the extract on reactive oxygen species (ROS) production by HeLa cells was studied, and a phytochemical evaluation was made by high performance liquid chromatography with diode array ...
13 Citations
#1Luísa Custódio (University of the Algarve)H-Index: 18
#2Eliana Fernandes (University of the Algarve)H-Index: 4
Last. Anabela Romano (University of the Algarve)H-Index: 23
view all 8 authors...
The methanol leaf extracts of female cultivars of the carob tree [Ceratonia siliqua L. (Fabaceae)] and of hermaphrodite and male trees were investigated for their contents of phenolic compounds, their in vitro antioxidant activity, measured by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging and linoleic acid system assays, and their in vitro tumor growth inhibition on HeLa cells. The different cultivars and trees showed high levels of phenols, and considerable variations in the amount of...
12 CitationsSource
#1Sandra Gonçalves (University of the Algarve)H-Index: 19
#2Ana Luisa Escapa (University of the Algarve)H-Index: 6
Last. Anabela Romano (University of the Algarve)H-Index: 23
view all 4 authors...
In this study, an efficient protocol was developed for in vitro propagation of Pinguicula lusitanica L., a rare insectivorous plant with pharmacological value and limited reproductive capacity. The effects of two concentrations (0.1 and 0.5 mg l−1) of a range of plant growth regulators, including cytokinins (BA, KIN, and ZEA) and auxins (IAA, IBA, and NAA), and three concentrations of MS medium macronutrients (total, 1/2 and 1/4MS) on proliferation and rooting, were investigated. P. lusitanica s...
12 CitationsSource
#1Luísa CustódioH-Index: 18
#2Eliana FernandesH-Index: 4
Last. Anabela RomanoH-Index: 23
view all 8 authors...
Source
#1Sandra Gonçalves (University of the Algarve)H-Index: 19
#2Ana Luisa Escapa (University of the Algarve)H-Index: 6
Last. Anabela Romano (University of the Algarve)H-Index: 23
view all 4 authors...
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