Stijn E. Verleden
Katholieke Universiteit Leuven
ImmunologyBronchiolitis obliteransLungLung transplantationMedicine
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Publications 262
#1Stijn E. Verleden (MHH: Hannover Medical School)H-Index: 25
Last. Danny Jonigk (MHH: Hannover Medical School)H-Index: 21
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Although chronic lung allograft dysfunction (CLAD) remains the major life-limiting factor following lung transplantation, much of its pathophysiology remains unknown. The discovery that CLAD can manifest both clinically and morphologically in vastly different ways led to the definition of distinct subtypes of CLAD. In this review, recent advances in our understanding of the pathophysiological mechanisms of the different phenotypes of CLAD will be discussed with a particular focus on tissue-based...
#1M. Kirby (RyeU: Ryerson University)H-Index: 1
#1Miranda KirbyH-Index: 20
Last. James C. Hogg (UBC: University of British Columbia)H-Index: 79
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1 CitationsSource
Lymphangio-leio-myomatosis (LAM) is a rare, cystic lung disease with progressive pulmonary function loss caused by progressively proliferating LAM cells. The degree of airway obstruction has not been well investigated within the pathogenesis of LAM. Using a combination of ex vivo CT, microCT and histology, the site and nature of airway obstruction in LAM explant lungs was compared to matched control lungs (n=5 each). The total number of airways per generation, total airway counts, terminal bronc...
#1Stijn E. Verleden (Katholieke Universiteit Leuven)H-Index: 25
#2Naoya Tanabe (Kyoto University)H-Index: 11
Last. Cindy Mai (Katholieke Universiteit Leuven)H-Index: 3
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Summary Background The observation that patients with idiopathic pulmonary fibrosis (IPF) can have higher than normal expiratory flow rates at low lung volumes led to the conclusion that the airways are spared in IPF. This study aimed to re-examine the hypothesis that airways are spared in IPF using a multiresolution imaging protocol that combines multidetector CT (MDCT), with micro-CT and histology. Methods This was a retrospective cohort study comparing explanted lungs from patients with sever...
1 CitationsSource
#1A. Vanstapel (Katholieke Universiteit Leuven)
#2Adriana Dubbeldam (Katholieke Universiteit Leuven)H-Index: 3
Last. Dirk Vanraemdonck (Katholieke Universiteit Leuven)H-Index: 55
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#1Jo Raskin (Katholieke Universiteit Leuven)H-Index: 1
#2A. Vanstapel (Katholieke Universiteit Leuven)
Last. Robin Vos (Katholieke Universiteit Leuven)H-Index: 30
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2 CitationsSource
#1C. Spence ('QUB': Queen's University Belfast)
#2Bart M. Vanaudenaerde (Katholieke Universiteit Leuven)H-Index: 31
Last. Stijn E. Verleden (Katholieke Universiteit Leuven)H-Index: 25
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ABSTRACT Background Alterations in the lung microbiota may drive disease development and progression in patients with chronic respiratory diseases. Following lung transplantation (LTx), azithromycin is used to both treat and prevent chronic lung allograft dysfunction (CLAD). The objective of this study was to determine the association between azithromycin use, CLAD, acute rejection, airway inflammation and bacterial microbiota composition and structure after LTx. Methods Bronchoalveolar lavage (...
#1Marnix Lebeer (Katholieke Universiteit Leuven)
#2J. Kaes (Katholieke Universiteit Leuven)
Last. Yolande LievensH-Index: 30
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#1Stijn E. Verleden (Katholieke Universiteit Leuven)H-Index: 25
Last. Geert Verleden (Katholieke Universiteit Leuven)H-Index: 54
view all 10 authors...
Rationale: Patients can change chronic lung allograft dysfunction (CLAD) phenotype, especially from BOS to mixed phenotype. Our aim was to further characterize these patients. Method: Mixed CLAD was defined as a restrictive physiology with persistent CT opacities, after initial bronchiolitis obliterans syndrome (BOS) diagnosis. The incidence, prognosis, pulmonary function, radiology, pathology, and airway inflammation were compared between patients with restrictive allograft syndrome (RAS) and m...
#1Laurens J. De Sadeleer (Katholieke Universiteit Leuven)H-Index: 4
#2Frederik Hermans (Katholieke Universiteit Leuven)H-Index: 2
Last. Wim Wuyts (Katholieke Universiteit Leuven)H-Index: 22
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According to a survey study of Wijsenbeek and colleagues [1], 76% of respiratory physicians believe fibrotic Hypersensitivity Pneumonitis (fibrotic HP, fHP) should be treated with corticosteroids (CS) as first line treatment. However, data to support such a strategy are limited and confined to acute farmer's lung [2]. Classically, HP patients are classified according to symptom chronicity in acute and chronic HP [3]. Based on new data, however, a stratification according to the (radiological) pr...