Xuemei Zeng
University of Pittsburgh
Publications 15
#1Christopher J. Bakkenist (University of Pittsburgh)H-Index: 23
#2R. Kenneth Czambel (University of Pittsburgh)H-Index: 3
Last.John C. Schmitz (University of Pittsburgh)H-Index: 12
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Abstract Since many anticancer therapies target DNA and DNA damage response pathways, biomarkers of DNA damage endpoints may prove valuable in basic and clinical cancer research. Ataxia telangiectasia-mutated (ATM) kinase is the principal regulator of cellular responses to DNA double-strand breaks (DSBs). In humans, ATM autophosphorylation at serine 1981 (p-S1981) is an immediate molecular response to nascent DSBs and ionizing radiation (IR). Here we describe the analytical characteristics and f...
#1Yang Li (University of Pittsburgh)H-Index: 1
#2Chelsea D. Merkel (University of Pittsburgh)H-Index: 2
Last.Adam V. Kwiatkowski (University of Pittsburgh)H-Index: 19
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The junctional complexes that couple cardiomyocytes must transmit the mechanical forces of contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects the actomyosin networks of neighboring cardiomyocytes and is required for proper heart function. Yet little is known about the molecular composition of the cardiomyocyte AJ or how it is organized to function under mechanical load. Here we define the architecture, dynamics and proteome of the cardiomyocyte AJ. Mouse neon...
4 CitationsSource
#2Guoshuang XuH-Index: 1
Last.Hongjiao OuyangH-Index: 3
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#1Sumeet A. KhetarpalH-Index: 13
#2Xuemei ZengH-Index: 8
Last.Daniel J. RaderH-Index: 137
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On the basis of new mechanistic studies of a mutant form of the apolipoprotein apoC-III that protects against coronary heart disease, Khetarpal et al. have developed therapeutic apoC-III-targeting monoclonal antibodies that lower circulating apoC-III protein and triglyceride levels in mice.
21 CitationsSource
#1Rong TanH-Index: 4
#2Satoshi Nakajima (University of Pittsburgh)H-Index: 25
Last.Li Lan (University of Pittsburgh)H-Index: 35
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Summary Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin structure and integrity. However, how telomere integrity is maintained, especially in response to damage, remains poorly understood. Here, we identify Nek7, a member of the Never in Mitosis Gene A (NIMA) kinase family, as a regulator of telomere integrity. Nek7 is recruited to telomeres and stabilizes TRF1 at telomeres after damage in an ATM activation-dependent manner. Nek7 deficiency leads to...
11 CitationsSource
#1Andrea Braganza (University of Pittsburgh)H-Index: 3
#2Jianfeng Li (USA: University of South Alabama)H-Index: 12
Last.Robert W. Sobol (USA: University of South Alabama)H-Index: 42
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10 CitationsSource
#1William C.W. Chen (University of Pittsburgh)H-Index: 13
#2Zhouguang Wang (University of Pittsburgh)H-Index: 17
Last.WangYadongH-Index: 35
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Heart attack is a global health problem that leads to significant morbidity, mortality, and health care burden. Adult human hearts have very limited regenerative capability after injury. However, evolutionarily primitive species generally have higher regenerative capacity than mammals. The extracellular matrix (ECM) may contribute to this difference. Mammalian cardiac ECM may not be optimally inductive for cardiac regeneration because of the fibrotic, instead of regenerative, responses in injure...
33 CitationsSource
#1David Gau (University of Pittsburgh)H-Index: 7
#2William Veon (University of Pittsburgh)H-Index: 2
Last.Partha Roy (University of Pittsburgh)H-Index: 20
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Objective Dynamic regulation of actin cytoskeleton is at the heart of all actin-based cellular events. In this study, we sought to identify novel post-translational modifications of Profilin-1 (Pfn1), an important regulator of actin polymerization in cells. Methodology We performed in vitro protein kinase assay followed by mass-spectrometry to identify Protein Kinase A (PKA) phosphorylation sites of Pfn1. By two-dimensional gel electrophoresis (2D-GE) analysis, we further examined the changes in...
5 CitationsSource
#1Lia R. Edmunds (University of Pittsburgh)H-Index: 7
#2P. Anthony Otero (University of Pittsburgh)H-Index: 4
Last.Edward V. Prochownik (University of Pittsburgh)H-Index: 36
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// Lia R. Edmunds 1,2 , P. Anthony Otero 3 , Lokendra Sharma 1,13 , Sonia D’Souza 1 , James M. Dolezal 1 , Sherin David 2 , Jie Lu 1 , Lauren Lamm 1 , Mahesh Basantani 4 , Pili Zhang 5 , Ian J. Sipula 4 , Lucy Li 5 , Xuemei Zeng 6 , Ying Ding 7 , Fei Ding 7 , Megan E. Beck 8 , Jerry Vockley 8 , Satdarshan P. S. Monga 9 , Erin E. Kershaw 4 , Robert M. O’Doherty 4 , Lisa E. Kratz 10 , Nathan A. Yates 6,11 , Eric P. Goetzman 8 , Donald Scott 5 , Andrew W. Duncan 3 and Edward V. Prochownik 1,2,12 1 ...
10 CitationsSource
#1Jennifer C. Boatz (University of Pittsburgh)H-Index: 5
#2Matthew J. Whitley (University of Pittsburgh)H-Index: 6
Last.Patrick C.A. van der Wel (University of Pittsburgh)H-Index: 25
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Human gamma-D-crystallin (HGD) is an extremely soluble (>400mg/mL in vivo) and stable protein that under certain conditions succumbs to protein aggregation, which is associated with cataract formation. Cataracts are the leading cause of blindness globally. Both environmental and genetic factors enable cataract formation by disrupting the solubility of HGD. Several chemical modifications are thought to be linked to loss of solubility and precipitation of HGD. The P23T mutant of HGD is genetically...