Herta Flor
University of Mannheim
PsychologyNeurosciencePhysical therapyChronic painMedicine
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Publications 664
#1Tamar R. Makin (UCL: University College London)H-Index: 20
#2Herta Flor (UMA: University of Mannheim)H-Index: 96
Abstract Following arm amputation the region that represented the missing hand in primary somatosensory cortex (S1) becomes deprived of its primary input, resulting in changed boundaries of the S1 body map. This remapping process has been termed ‘reorganisation’ and has been attributed to multiple mechanisms, including increased expression of previously masked inputs. In a maladaptive plasticity model, such reorganisation has been associated with phantom limb pain (PLP). Brain activity associate...
#1Rachel M. Brouwer (UU: Utrecht University)H-Index: 32
#2Marieke Klein (UCSD: University of California, San Diego)
Last. Nitin Gogtay (APA: American Psychological Association)
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Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. While heritable, specific loci in the genome that influence these rates are largely unknown. Here, we sought to find common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association analysis of longitudinal changes in brain morphology across the lifespan. Longitudinal ma...
#1Hongcai Liu (Heidelberg University)
#2Jamila Andoh (Heidelberg University)H-Index: 8
Last. Herta Flor (Heidelberg University)H-Index: 96
view all 9 authors...
BACKGROUND: Following amputation, nearly all amputees report non-painful phantom phenomena and many of them suffer from chronic phantom limb pain (PLP) and residual limb pain (RLP). The etiology of PLP remains elusive and there is an ongoing debate on the role of peripheral and central mechanisms. Few studies have examined the entire somatosensory pathway from the truncated nerves to the cortex in amputees with PLP compared to those without PLP. The relationship between afferent input, somatosen...
#1Tianye JiaH-Index: 14
#2Alex Ing ('KCL': King's College London)H-Index: 3
Last. Uli BrombergH-Index: 18
view all 30 authors...
Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social–emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual be...
#1Tristram A. Lett (Charité)H-Index: 12
#2Bob O. Vogel (Charité)H-Index: 2
Last. Henrik Walter (Charité)H-Index: 60
view all 39 authors...
Recent large-scale, genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with general intelligence. The cumulative influence of these loci on brain structure is unknown. We examined if cortical morphology mediates the relationship between GWAS-derived polygenic scores for intelligence (PSi) and g-factor. Using the effect sizes from one of the largest GWAS meta-analysis on general intelligence to date, PSi were calculated among 10 P value thresholds. PSi were...
#1Gabriel RobertH-Index: 2
#2Qiang Luo (Fudan University)H-Index: 12
Last. Gunter SchumannH-Index: 51
view all 33 authors...
Importance Alcohol abuse correlates with gray matter development in adolescents, but the directionality of this association remains unknown. Objective To investigate the directionality of the association between gray matter development and increase in frequency of drunkenness among adolescents. Design, Setting, and Participants This cohort study analyzed participants of IMAGEN, a multicenter brain imaging study of healthy adolescents in 8 European sites in Germany (Mannheim, Dresden, Berlin, and...
1 CitationsSource
#1Boo Young Chung (Heidelberg University)H-Index: 2
#2Saskia Hensel (Heidelberg University)H-Index: 2
Last. Herta Flor (Heidelberg University)H-Index: 96
view all 5 authors...
BACKGROUND: Stress-related dissociation has been shown to negatively co-vary with pain perception in current borderline personality disorder (cBPD). While remission of the disorder (rBPD) is associated with normalized pain perception, it remains unclear whether dissociation proneness is still enhanced in this group and how this feature interacts with pain sensitivity. METHODS: Twenty-five cBPD patients, 20 rBPD patients, and 24 healthy controls (HC) participated in an experiment using the script...
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Mary Agnes B. McMahon (SC: University of Southern California)H-Index: 1
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INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
7 CitationsSource
#1Evangelos Papanastasiou ('KCL': King's College London)H-Index: 6
#2Elias Mouchlianitis ('KCL': King's College London)H-Index: 5
Last. Sylvane Desrivières ('KCL': King's College London)H-Index: 25
view all 30 authors...
Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal region...
#1Andreas Heinz (Charité)H-Index: 86
#2Falk Kiefer (Heidelberg University)H-Index: 43
Last. Rainer Spanagel (Heidelberg University)H-Index: 74
view all 44 authors...
One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Resea...
4 CitationsSource