Christopher Aiken
University of Pittsburgh
Molecular biologyVirologyCapsidVirusBiology
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Publications 111
#1Christopher Aiken (VUMC: Vanderbilt University Medical Center)H-Index: 44
The host protein cyclophilin A binds to the HIV-1 capsid and its role in infection has long been enigmatic. A new study shows that this interaction protects the virus from inhibition by TRIM5α in physiologically relevant primary human cells.
#2Akatsuki SaitoH-Index: 14
Last. Masahiro YamashitaH-Index: 22
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#1Stephanie K. Carnes (VUMC: Vanderbilt University Medical Center)H-Index: 2
#2Christopher Aiken (VUMC: Vanderbilt University Medical Center)H-Index: 44
#1Wang Peng (EMBL-EBI: European Bioinformatics Institute)H-Index: 1
#2Jiong Shi (VUMC: Vanderbilt University Medical Center)H-Index: 14
Last. Till Böcking (EMBL-EBI: European Bioinformatics Institute)H-Index: 30
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Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site. Recent structural analysis of CypA in complex with CA tubes in conjunction with molecular dynamics simulations identified a secondary CA binding site on CypA that allows a bridging interaction with two hexameric subunits of the assembled CA lattice, leading to capsid stab...
1 CitationsSource
#2Jing ZhouH-Index: 16
Last. Chandravanu DashH-Index: 9
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1 CitationsSource
#1Sanela RankovicH-Index: 3
#2Ruben RamalhoH-Index: 6
Last. Itay RoussoH-Index: 18
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3 CitationsSource
#2Jing ZhouH-Index: 16
Last. Christopher AikenH-Index: 44
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4 CitationsSource
Purpose of reviewTo summarize recent advances in the discovery of chemical inhibitors targeting the HIV capsid and research on their mechanisms of action.Recent findingsHIV infection is critically dependent on functions of the viral capsid. Numerous studies have reported the identification of a vari
11 CitationsSource
#1Mingzhang Wang (UD: University of Delaware)H-Index: 5
#2Caitlin M. Quinn (UD: University of Delaware)H-Index: 6
Last. Tatyana Polenova (UD: University of Delaware)H-Index: 32
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Maturation of HIV-1 particles encompasses a complex morphological transformation of Gag via an orchestrated series of proteolytic cleavage events. A longstanding question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA–SP1), which represents an intermediate during maturation of the HIV-1 virus. By integrating NMR, cryo-EM, and molecular dynamics simulations, we show that in CA–SP1 tubes assembled in vitro, which represent the features of an intermediate assembly sta...
18 CitationsSource