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Hendrik Milting
Ruhr University Bochum
169Publications
26H-index
2,441Citations
Publications 169
Newest
#1Carola Fischer (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Hendrik Milting (RUB: Ruhr University Bochum)H-Index: 26
Last.Roland Tomasi (LMU: Ludwig Maximilian University of Munich)H-Index: 3
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The original version of this Article incorrectly acknowledged Elisabeth Reiser and Rene Schramm as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.
#1Kirstin HoffH-Index: 3
#2M. Lemme (UHH: University of Hamburg)
Last.Almuth Caliebe (CAU: University of Kiel)H-Index: 18
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Cardiac disease modelling using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) requires thorough insight into cardiac cell type differentiation processes. However, current methods to discriminate different cardiac cell types are mostly time-consuming, are costly and often provide imprecise phenotypic evaluation. DNA methylation plays a critical role during early heart development and cardiac cellular specification. We therefore investigated the DNA methylation pattern in d...
#1Carola Fischer (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Hendrik Milting (RUB: Ruhr University Bochum)H-Index: 26
Last.Roland Tomasi (LMU: Ludwig Maximilian University of Munich)H-Index: 3
view all 10 authors...
In vitro models incorporating the complexity and function of adult human tissues are highly desired for translational research. Whilst vital slices of human myocardium approach these demands, their rapid degeneration in tissue culture precludes long-term experimentation. Here, we report preservation of structure and performance of human myocardium under conditions of physiological preload, compliance, and continuous excitation. In biomimetic culture, tissue slices prepared from explanted failing...
Abstract Background The combination of cardiomyocyte (CM) and vascular cell (VC) fetal reprogramming upon stress culminates in end-stage heart failure (HF) by mechanisms that are not fully understood. Previous studies suggest KLF15 as a key regulator of CM hypertrophy. Objectives This study aimed to characterize the impact of KLF15-dependent cardiac transcriptional networks leading to HF progression, amenable to therapeutic intervention in the adult heart. Methods Transcriptomic bioinformatics, ...
In the last few decades, many pathogenic or likely pathogenic genetic mutations in over hundred different genes have been described for non-ischemic, genetic cardiomyopathies. However, the functional knowledge about most of these mutations is still limited because the generation of adequate animal models is time-consuming and challenging. Therefore, human induced pluripotent stem cells (iPSCs) carrying specific cardiomyopathy-associated mutations are a promising alternative. Since the original d...
#1Sebastiaan van Heesch (MDC: Max Delbrück Center for Molecular Medicine)
#2Franziska Witte (MDC: Max Delbrück Center for Molecular Medicine)
Last.Clara-Louisa Sandmann (MDC: Max Delbrück Center for Molecular Medicine)
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Summary Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be fre...
#1Anna Gaertner (RUB: Ruhr University Bochum)H-Index: 4
#2Andreas Brodehl (RUB: Ruhr University Bochum)H-Index: 8
Last.Hendrik Milting (RUB: Ruhr University Bochum)H-Index: 26
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#1Andreas Brodehl (RUB: Ruhr University Bochum)H-Index: 8
#2Hans Ebbinghaus (RUB: Ruhr University Bochum)H-Index: 1
Last.Hendrik Milting (RUB: Ruhr University Bochum)H-Index: 26
view all 6 authors...
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