Elisa Nemes
University of Cape Town
ImmunologyVaccinationMycobacterium tuberculosisTuberculosisMedicine
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Publications 38
#1Maria PapadopoulouH-Index: 3
#2Tanya Dimova (ULB: Université libre de Bruxelles)H-Index: 2
Last. Thomas J. Scriba (UCT: University of Cape Town)H-Index: 47
view all 12 authors...
Vγ9Vδ2 T cells are a major human blood γδ T cell population that respond in a T cell receptor (TCR)-dependent manner to phosphoantigens which are generated by a variety of microorganisms. It is not clear how Vγ9Vδ2 T cells react toward the sudden microbial exposure early after birth. We found that human Vγ9Vδ2 T cells with a public/shared fetal-derived TCR repertoire expanded within 10 wk postpartum. Such an expansion was not observed in non-Vγ9Vδ2 γδ T cells, which possessed a private TCR reper...
#1Erick Wekesa Bunyasi (UCT: University of Cape Town)H-Index: 3
#2Humphrey Mulenga (UCT: University of Cape Town)H-Index: 11
Last. Mark Hatherill (UCT: University of Cape Town)H-Index: 40
view all 10 authors...
BACKGROUND Adolescents in the Western Cape Province of South Africa had high force of Mycobacterium tuberculosis (MTB) infection (14% per annum) and high TB incidence (710 per 100,000 person-years) in 2005. We describe subsequent temporal changes in adolescent TB disease notification rates for the decade 2005-2015. METHOD We conducted an analysis of patient-level adolescent (age 10-19 years) TB disease data, obtained from an electronic TB register in the Breede Valley sub-district, Western Cape ...
#1Cheleka A. M. Mpande (UCT: University of Cape Town)H-Index: 2
#2Munyaradzi Musvosvi (UCT: University of Cape Town)H-Index: 9
Last. Gerlinde Obermoser (Stanford University)H-Index: 18
view all 16 authors...
Background: Provision of tuberculosis preventive treatment (TPT) to individuals with Mycobacterium tuberculosis (M.tb) infection (TBI) is a key strategy to reduce the global tuberculosis burden. Tuberculosis risk is significantly higher after recent compared to remote TBI. We aimed to define a blood-based biomarker, measured with a simple flow cytometry assay, to stratify different stages of TBI to infer risk of disease. Methods: Healthy adolescents were serially tested with QuantiFERON-TB Gold ...
#1Lucy MupfumiH-Index: 7
#1Lucy Mupfumi (UB: University of Botswana)H-Index: 2
Last. Thomas J. Scriba (UCT: University of Cape Town)H-Index: 47
view all 12 authors...
The performance of host blood-based biomarkers for tuberculosis (TB) in HIV-infected patients on antiretroviral therapy (ART) has not been fully assessed. We evaluated the immune phenotype and functionality of antigen-specific T-cell responses in HIV positive (+) participants with TB (n = 12) compared to HIV negative (−) participants with either TB (n = 9) or latent TB infection (LTBI) (n = 9). We show that the cytokine profile of Mtb-specific CD4+ T-cells in participants with TB, regardless of ...
2 CitationsSource
#1Gwendolyn Swarbrick (OHSU: Oregon Health & Science University)H-Index: 13
#2Anele Gela (UCT: University of Cape Town)H-Index: 2
Last. Deborah A. Lewinsohn (OHSU: Oregon Health & Science University)H-Index: 30
view all 17 authors...
MR1-restricted T cells (MR1Ts) are a T cell subset that recognizes and mediate host immune responses to a broad array of microbial pathogens, including Mycobacterium tuberculosis. Here, we sought to characterize development of circulating human MR1T cells, defined by MR1-5-OP-RU tetramer labelling and expression of TRAV1-2/CD26/CD161. We analyzed postnatal expansion, maturation and functionality of peripheral blood MR1T cells in cohorts from three different geographic settings with different TB ...
#1Sara Suliman (UCT: University of Cape Town)H-Index: 13
#2Melissa Murphy (UCT: University of Cape Town)H-Index: 2
Last. Thomas J. ScribaH-Index: 47
view all 19 authors...
Tuberculosis (TB) is the leading cause of mortality from a single infectious agent, Mycobacterium tuberculosis. Relevant immune targets of the partially efficacious TB vaccine bacille Calmette–Guerin (BCG) remain poorly defined. Mucosal-associated invariant T (MAIT) cells are MHC-related protein 1 (MR1)–restricted T cells, which are reactive against M. tuberculosis, and underexplored as potential TB vaccine targets. We sought to determine whether BCG vaccination activated mycobacteria-specific M...
5 CitationsSource
#1Elisa Nemes (UCT: University of Cape Town)H-Index: 11
#2Deborah Abrahams (UCT: University of Cape Town)H-Index: 11
Last. Morten RuhwaldH-Index: 26
view all 23 authors...
BACKGROUND: Early secretory antigenic target-6 (ESAT-6) is an immunodominant Mycobacterium tuberculosis (M.tb) antigen included in novel vaccines against tuberculosis (TB) and in interferon-gamma (IFN-γ) release assays (IGRAs). Therefore, the availability of an ESAT-6-free IGRA is essential to determine M.tb infection status following vaccination with ESAT-6-containing vaccines. We aimed to qualify a recently developed ESAT-6-free IGRA and to assess its diagnostic performance in comparison to Qu...
4 CitationsSource
#1Shabaana A. Khader (WashU: Washington University in St. Louis)H-Index: 37
#2Maziar Divangahi (MUHC: McGill University Health Centre)H-Index: 34
Last. Mihai G. NeteaH-Index: 115
view all 14 authors...
Vaccine development against tuberculosis (TB) is based on the induction of adaptive immune responses endowed with long-term memory against mycobacterial antigens. Memory B and T cells initiate a rapid and robust immune response upon encounter with Mycobacterium tuberculosis, thus achieving long-lasting protection against infection. Recent studies have shown, however, that innate immune cell populations such as myeloid cells and NK cells also undergo functional adaptation after infection or vacci...
9 CitationsSource
#1Mark F. Cotton (Stellenbosch University)H-Index: 11
#2Helena Rabie (Stellenbosch University)H-Index: 24
Last. Savita Pahwa (UM: University of Miami)H-Index: 53
view all 13 authors...
Background The immune reconstitution inflammatory syndrome (IRIS) in HIV-infected infants and young children is relatively understudied in regions endemic for HIV and TB. We aimed to describe incidence, clinical features and risk factors of pediatric IRIS in Sub-Saharan Africa and India. Methods and findings We conducted an observational multi-centred prospective clinical study from December 2010 to September 2013 in children <72 months of age recruited from public antiretroviral programs. The m...
#1Erick Wekesa Bunyasi (UCT: University of Cape Town)H-Index: 3
#2Hennie Geldenhuys (UCT: University of Cape Town)H-Index: 20
Last. Mark Hatherill (UCT: University of Cape Town)H-Index: 3
view all 13 authors...
SETTING South Africa. OBJECTIVE 1) To measure changes in the adolescent prevalence of latent tuberculous infection (LTBI) between 2005 and 2015, and 2) to evaluate medium-term impact of TB control measures on LTBI prevalence. DESIGN We compared baseline data from a cohort study (2005-2007) and a vaccine trial (2014-2015) which enrolled adolescents from the same eight South African high schools. LTBI was defined based on QuantiFERON®-TB Gold In-Tube test positivity. RESULTS We analysed data from ...
2 CitationsSource