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Elisa Nemes
University of Cape Town
34Publications
11H-index
504Citations
Publications 35
Newest
MR1-restricted T cells (MR1Ts) are a T cell subset that recognizes and mediate host immune responses to a broad array of microbial pathogens, including Mycobacterium tuberculosis. Here, we sought to characterize development of circulating human MR1T cells, defined by MR1-5-OP-RU tetramer labelling and expression of TRAV1-2/CD26/CD161. We analyzed postnatal expansion, maturation and functionality of peripheral blood MR1T cells in cohorts from three different geographic settings with different TB ...
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#1Sara SulimanH-Index: 11
#2Melissa MurphyH-Index: 1
Last.Thomas J. ScribaH-Index: 41
view all 19 authors...
Tuberculosis (TB) is the leading cause of mortality from a single infectious agent, Mycobacterium tuberculosis. Relevant immune targets of the partially efficacious TB vaccine bacille Calmette–Guerin (BCG) remain poorly defined. Mucosal-associated invariant T (MAIT) cells are MHC-related protein 1 (MR1)–restricted T cells, which are reactive against M. tuberculosis, and underexplored as potential TB vaccine targets. We sought to determine whether BCG vaccination activated mycobacteria-specific M...
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#1Elisa Nemes (UCT: University of Cape Town)H-Index: 11
#2Deborah Abrahams (UCT: University of Cape Town)H-Index: 10
Last.Morten RuhwaldH-Index: 25
view all 23 authors...
2 CitationsSource
Vaccine development against tuberculosis (TB) is based on the induction of adaptive immune responses endowed with long-term memory against mycobacterial antigens. Memory B and T cells initiate a rapid and robust immune response upon encounter with Mycobacterium tuberculosis, thus achieving long-lasting protection against infection. Recent studies have shown, however, that innate immune cell populations such as myeloid cells and NK cells also undergo functional adaptation after infection or vacci...
1 CitationsSource
#1Mark F. Cotton (Stellenbosch University)H-Index: 8
#2Helena Rabie (Stellenbosch University)H-Index: 22
Last.Savita G Pahwa (UM: University of Miami)H-Index: 51
view all 13 authors...
Background The immune reconstitution inflammatory syndrome (IRIS) in HIV-infected infants and young children is relatively understudied in regions endemic for HIV and TB. We aimed to describe incidence, clinical features and risk factors of pediatric IRIS in Sub-Saharan Africa and India. Methods and findings We conducted an observational multi-centred prospective clinical study from December 2010 to September 2013 in children <72 months of age recruited from public antiretroviral programs. The m...
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#1Erick Wekesa Bunyasi (UCT: University of Cape Town)H-Index: 3
#2Hennie Geldenhuys (UCT: University of Cape Town)H-Index: 18
Last.Mark Hatherill (UCT: University of Cape Town)H-Index: 3
view all 13 authors...
SETTING South Africa. OBJECTIVE 1) To measure changes in the adolescent prevalence of latent tuberculous infection (LTBI) between 2005 and 2015, and 2) to evaluate medium-term impact of TB control measures on LTBI prevalence. DESIGN We compared baseline data from a cohort study (2005-2007) and a vaccine trial (2014-2015) which enrolled adolescents from the same eight South African high schools. LTBI was defined based on QuantiFERON®-TB Gold In-Tube test positivity. RESULTS We analysed data from ...
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#1Erick Wekesa Bunyasi (UCT: University of Cape Town)H-Index: 3
#2Humphrey Mulenga (UCT: University of Cape Town)H-Index: 10
Last.Mark Hatherill (UCT: University of Cape Town)H-Index: 35
view all 10 authors...
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#1Darragh Duffy (Pasteur Institute)H-Index: 18
#2Elisa Nemes (UCT: University of Cape Town)H-Index: 11
Last.Matthew L. Albert (Genentech)H-Index: 10
view all 16 authors...
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) infection and is a major public health problem with an estimated 1.7 billion persons infected worldwide. Clinical challenges in TB include the lack of a blood-based test for active disease, and the absence of prognostic biomarkers for early treatment response. Current blood based tests, such as QuantiFERON-TB Gold (QFT), are based on an IFN{gamma} readout following Mtb antigen stimulation. However, they do not distinguish active TB ...
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#1Miguel Rodo (UCT: University of Cape Town)H-Index: 2
#2Virginie Rozot (UCT: University of Cape Town)H-Index: 13
Last.Thomas J. Scriba (UCT: University of Cape Town)H-Index: 41
view all 7 authors...
Eradication of tuberculosis (TB), the world's leading cause of death due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to perform a statistically rigorous comparison of the antigen-specific T cell responses induced by six novel TB vaccine candidates and the only licensed TB vaccine, Bacillus Calmette-Gue...
8 CitationsSource
#1Miguel RodoH-Index: 2
#2Elisa NemesH-Index: 11
Last.Virginie RozotH-Index: 13
view all 7 authors...
Pre-print submitted to BioRxiv.Abstract: Eradication of tuberculosis (TB), the world's leading cause of death due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large - scale efficacy trials due to limited global resources. We aimed to perform a statistically rigorous comparison of the antigen - specific T cell responses induced by six novel TB vaccine candidates and the on...
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