Costanza Casiraghi
University of Bologna
Integrin, beta 6VirologyOncolytic virusBiologyCancer cell
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Publications 5
#1Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
#2Andrea Vannini (UNIBO: University of Bologna)H-Index: 7
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
view all 11 authors...
Oncolytic herpes simplex viruses (oHSVs) showed efficacy in clinical trials and practice. Most of them gain cancer-specificity from deletions/mutations in genes that counteract the host response, and grow selectively in cancer cells defective in anti-viral response. Because of the deletions/mutations, they are frequently attenuated or over-attenuated. We developed next-generation oHSVs, which carry no deletion/mutation, gain cancer-specificity from specific retargeting to tumor cell receptors—e....
10 CitationsSource
#1Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
#2Valentina Gatta (UNIBO: University of Bologna)H-Index: 4
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
view all 6 authors...
7 CitationsSource
#1Kathrin MoorH-Index: 5
#2Médéric DiardH-Index: 15
Last. Emma SlackH-Index: 27
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Oral-vaccine-induced IgA cross-links growing bacteria into clonal aggregates, inhibiting pathogenesis, adaption and the spread of antimicrobial resistance genes.
78 CitationsSource
#1Costanza Casiraghi (UNIBO: University of Bologna)H-Index: 4
#2Tatiana Gianni (UNIBO: University of Bologna)H-Index: 15
Last. Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
view all 3 authors...
We report that αvβ3 integrin strongly affects the innate immune response in epithelial cells. αvβ3 integrin greatly increased the response elicited via plasma membrane Toll-like receptors (TLRs) by herpes simplex virus or bacterial ligands. The endosomal TLR3, not the cytosolic sensor interferon gamma-inducible protein 16 (IFI16), was also boosted by αvβ3 integrin. The boosting was exerted specifically by αvβ3 integrin but not by αvβ6 or αvβ8 integrin. Current and previous work indicates that in...
6 CitationsSource
#2Biljana PetrovicH-Index: 5
Last. Valentina GattaH-Index: 4
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Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy, and depend on tumor cell proliferation. They grow robustly in cancer cells, provided that these are deficient in host cell responses, which is often the case. To overcome the attenuation limits, a strategy is to render the virus highly cancer-speci...
14 CitationsSource