Jera Jeruc
University of Ljubljana
Publications 27
#1Jera Jeruc (University of Ljubljana)H-Index: 9
#2David DrobneH-Index: 6
Last.Nina Zidar (University of Ljubljana)H-Index: 24
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#1Žiga Urlep (University of Ljubljana)H-Index: 3
#2Gregor Lorbek (University of Ljubljana)H-Index: 5
Last.Damjana Rozman (University of Ljubljana)H-Index: 28
view all 12 authors...
Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling
The aim of the study was to investigate morphological and functional characteristics of oesophageal epithelial barrier in children with cystic fibrosis (CF) with or without gastro-oesophageal reflux disease (GORD) in comparison to healthy controls.Oesophagogastroduodenoscopy with oesophageal biopsies and combined oesophageal multichannel intraluminal impedance-pH monitoring was performed in 17 children with CF (CFtot) with (CFgord) or without GORD (CFnorm). Histological combined severity score w...
#1Naoto KurodaH-Index: 24
#2Kenji YoritaH-Index: 11
Last.Mahul B. AminH-Index: 69
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Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) was first identified in 2004 and has been integrated into the 2016 WHO classification of RCC. Succinate dehydrogenase (SDH) is an enzyme complex composed of four protein subunits (SDHA, SDHB, SDHC and SDHD). The tumor which presents this enzyme mutation accounts for 0.05 to 0.2% of all renal carcinomas. Multiple tumors may occur in approximately 30% of affected patients. SDHB-deficient RCC is the most frequent, and the tumor hist...
#1Gregor LorbekH-Index: 5
#2Martina PeršeH-Index: 15
Last.Damjana RozmanH-Index: 8
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We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14α-demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholesterol. LKO mice developed hepatomegaly with oval cell proliferation, fibrosis and inflammation, but without steatosis. The key trigger was reduced cholesterol esters that provoked cell cycle arrest, se...
#1Vesna Jurčić (University of Ljubljana)H-Index: 6
Last.Jera Jeruc (University of Ljubljana)H-Index: 9
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A 67-year-old woman with a history of recurrent urinary tract infections was admitted for investigation of intermittent gross hematuria and left flank pain. All blood tests were normal. Urinalysis revealed hematuria. Urine cultures were negative. Cystoscopy was unremarkable. Urine cytology was inconclusive; there were small clusters of urothelial cells showing mild atypia. Retrograde pyelography (Figure 1) and computed tomography urography were performed, showing hydroureteronephrosis above a tu...