Michael A P Bloomfield
University College London
Publications 45
#1Enrico D'Ambrosio (University of Bari)
#2Tarik Dahoun (University of Oxford)H-Index: 3
Last.James Walters (Cardiff University)H-Index: 33
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Abstract One of the most statistically significant loci to result from large-scale GWAS of schizophrenia is 10q24.32. However, it is still unclear how this locus is involved in the pathoaetiology of schizophrenia. The hypothesis that presynaptic dopamine dysfunction underlies schizophrenia is one of the leading theories of the pathophysiology of the disorder. Supporting this, molecular imaging studies show evidence for elevated dopamine synthesis and release capacity. Thus, altered dopamine func...
#1Matthew B. Wall (UCL: University College London)H-Index: 19
#2Rebecca Anne Pope (UCL: University College London)H-Index: 3
Last.Abigail M. Freeman (UCL: University College London)
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Background:Two major constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC.Aims:We examined the effects of two strains of cannabis and placebo on the human brain’s resting-state networks using fMRI.Methods:Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug treatments and scanning sessions. Treatments were cannabis contain...
#1Michael A P Bloomfield (UCL: University College London)H-Index: 8
#2Mustapha Modaffar (UCL: University College London)
Last.Oliver Howes ('KCL': King's College London)H-Index: 47
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#1Tom P. FreemanH-Index: 20
#2Chandni Hindocha (UCL: University College London)H-Index: 10
Last.Michael A P BloomfieldH-Index: 8
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### What you need to know Until recently, cannabis and its derivatives were widely restricted under legislation which stated they had no medical value and carried a substantial risk of misuse. Policy is rapidly changing, and cannabis can now be prescribed for medicinal use in many countries, including the UK. This provides important new opportunities for treating patients although these need to be weighed up against potential risks. Several different medicinal products exist, with contrasting me...
#2Chandni Hindocha (UCL: University College London)H-Index: 10
Last.Tom P. FreemanH-Index: 20
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Abstract The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Δ 9 -tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB 1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on...