Michael A. P. Bloomfield
University College London
PsychiatryPsychologyCannabisDopamineClinical psychology
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Publications 45
#1Sophie M. Allan (UEA: University of East Anglia)H-Index: 1
#2Rebecca Bealey (UEA: University of East Anglia)
Last. Richard Meiser-Stedman (UEA: University of East Anglia)H-Index: 22
view all 8 authors...
Background: Healthcare workers (HCWs) are considered at elevated risk of experiencing mental health disorders in working with patients with COVID-19. Aims: To estimate the prevalence of common mental health disorders in HCWs based in hospitals where pandemic-affected patients were treated. Method: Databases were searched for studies published before 30th March 2020. Quantitative synthesis was used to obtain estimates of the prevalence of mental health disorders in four time windows, determined a...
#1Will LawnH-Index: 9
#2Claire MokryszH-Index: 10
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#1Claire Mokrysz (UCL: University College London)H-Index: 10
#2Natacha D. C. Shaban (UCL: University College London)H-Index: 3
Last. Cja Morgan (University of Exeter)H-Index: 36
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BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We investigate whether cannabis inhalation leads to psychotic-like symptoms and speech illusion; and whether cannabidiol (CBD) blunts such effects (study 1) and adolescence heightens such effects (study 2). METHODS: Two double-blind placebo-controlled studies, assessing speech illus...
Abstract Acute and chronic exposure to cannabis and its main psychoactive component, 9-tetrahydrocannabinol (THC), is associated with changes in brain function and cerebral blood flow (CBF). We therefore sought to systematically review the literature on the effects of THC on CBF following PRISMA guidelines. Studies assessing the acute and chronic effects of THC on CBF, perfusion and volume were searched in the PubMed database between January 1972 and June 2019. We included thirty-four studies, w...
#2Fatin N I B Yusuf (UCL: University College London)
Last. Alexandra Pitman (NIHR: National Institute for Health Research)H-Index: 12
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Summary Developmental trauma is associated with an increased risk of psychosis and predicts poor prognosis. Despite this association, little is known about which treatments work best for survivors of developmental trauma with psychosis. We sought to do the first review, to our knowledge, to investigate treatments for people with psychotic and dissociative symptoms who have a history of developmental trauma. We searched MEDLINE, PsychINFO, and Google Scholar for studies reporting psychological an...
#2Robert McCutcheon (Imperial College London)H-Index: 12
Last. Oliver D. Howes (Imperial College London)H-Index: 52
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Chronic psychosocial adversity induces vulnerability to mental illnesses. Animal studies demonstrate that this may be mediated by dopaminergic dysfunction. We therefore investigated whether long-term exposure to psychosocial adversity was associated with dopamine dysfunction and its relationship to psychological and physiological responses to acute stress. Using 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine ([18F]-DOPA) positron emission tomography (PET), we compared dopamine synthesis capacity i...
#1Tarik Dahoun (University of Oxford)H-Index: 3
#2Matthew M. NourH-Index: 9
Last. Oliver D. Howes (Imperial College London)H-Index: 52
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Childhood trauma is a risk factor for psychosis. Amphetamine increases synaptic striatal dopamine levels and can induce positive psychotic symptoms in healthy individuals and patients with schizophrenia. Socio-developmental hypotheses of psychosis propose that childhood trauma and other environmental risk factors sensitize the dopamine system to increase the risk of psychotic symptoms, but this remains to be tested in humans. We used [11C]-(+)-PHNO positron emission tomography to measure striata...
#1Robert McCutcheon (Imperial College London)H-Index: 12
Last. Oliver D. Howes (Imperial College London)H-Index: 52
view all 5 authors...
Abstract Psychosocial stressors including childhood adversity, migration, and living in an urban environment, have been associated with several psychiatric disorders, including psychotic disorders. The neural and psychological mechanisms mediating this relationship remain unclear. In parallel, alterations in corticostriatal connectivity and abnormalities in the processing of salience, are seen in psychotic disorders. Aberrant functioning of these mechanisms secondary to chronic stress exposure, ...
1 CitationsSource
#1Enrico D'Ambrosio (University of Bari)H-Index: 6
#2Tarik Dahoun (University of Oxford)H-Index: 3
Last. Oliver D. HowesH-Index: 52
view all 11 authors...
Abstract One of the most statistically significant loci to result from large-scale GWAS of schizophrenia is 10q24.32. However, it is still unclear how this locus is involved in the pathoaetiology of schizophrenia. The hypothesis that presynaptic dopamine dysfunction underlies schizophrenia is one of the leading theories of the pathophysiology of the disorder. Supporting this, molecular imaging studies show evidence for elevated dopamine synthesis and release capacity. Thus, altered dopamine func...
#1Matthew B. Wall (UCL: University College London)H-Index: 19
#2Rebecca A. Pope (UCL: University College London)H-Index: 4
Last. Valerie Curran (UCL: University College London)H-Index: 8
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Background:Two major constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC.Aims:We examined the effects of two strains of cannabis and placebo on the human brain’s resting-state networks using fMRI.Methods:Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug treatments and scanning sessions. Treatments were cannabis contain...
5 CitationsSource