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Javier A. Carrero
Washington University in St. Louis
58Publications
24H-index
3,530Citations
Publications 58
Newest
Published on Sep 1, 2018in Diabetes7.20
Javier A. Carrero24
Estimated H-index: 24
(WashU: Washington University in St. Louis),
N. Benshoff16
Estimated H-index: 16
(WashU: Washington University in St. Louis)
+ 1 AuthorsEmil R. Unanue84
Estimated H-index: 84
(WashU: Washington University in St. Louis)
The role of interferons, either pathogenic or protective, during autoimmune diabetes remains controversial. Herein, we examine the progression of diabetes in non-obese diabetic (NOD) mice lacking the type I (IFNAR) or type II (IFNGR) interferon receptors and, for the first time, in mice deficient in both receptors (DKO). All mice were bred, maintained, and monitored in a single specific pathogen-free facility with high female and low male diabetes incidence. Our expectation was that removal of i...
Published on Jun 1, 2018in Diabetologia7.11
Bernd H. Zinselmeyer20
Estimated H-index: 20
(WashU: Washington University in St. Louis),
Anthony N. Vomund6
Estimated H-index: 6
(WashU: Washington University in St. Louis)
+ 3 AuthorsEmil R. Unanue84
Estimated H-index: 84
(WashU: Washington University in St. Louis)
Aims/hypothesis We studied here the interactions between the resident macrophages of pancreatic islets with beta cells and the blood vasculature. We also examined the immunological consequences of such interactions.
Published on Jan 1, 2018in Journal of The American Society of Nephrology8.55
Sebastian Brähler6
Estimated H-index: 6
,
Bernd H. Zinselmeyer20
Estimated H-index: 20
+ 19 AuthorsDerek J. Theisen7
Estimated H-index: 7
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, to perform an important sentinel function. However, previous studies of DC function used markers, such as CD11c or CX3CR1, that are not unique to DCs. Here, we evaluated the role of DCs in renal inflammation using a CD11c reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46 -GFP and Snx22 -GFP. Multiphoton microscopy of kidney sections confirmed...
Javier A. Carrero24
Estimated H-index: 24
(WashU: Washington University in St. Louis),
Derrick P. McCarthy1
Estimated H-index: 1
(WashU: Washington University in St. Louis)
+ 5 AuthorsEmil R. Unanue84
Estimated H-index: 84
(WashU: Washington University in St. Louis)
Abstract Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response, insulin content, and transcriptional profile. In NOD mice depleted of islet-resident macrophages starting at 3 wk of age, several changes occurred: (i) the early entrance...
Published on May 1, 2017in European Journal of Immunology4.70
Carolina Valderrama2
Estimated H-index: 2
(National University of Colombia),
Amy L. Clark9
Estimated H-index: 9
(WashU: Washington University in St. Louis)
+ 2 AuthorsJavier A. Carrero24
Estimated H-index: 24
(WashU: Washington University in St. Louis)
Type I interferons (IFNs) induce a detrimental response during Listeria monocytogenes (L. monocytogenes) infection. We were interested in identifying mechanisms linking IFN signaling to negative host responses against L. monocytogenes infection. Herein, we found that infection of myeloid cells with L. monocytogenes led to a coordinated induction of type I IFNs and activation of the integrated stress response (ISR). Infected cells did not induce Xbp1 splicing or BiP upregulation, indicating that ...
Published on Mar 31, 2017in eLife7.55
Abigail J. Morales2
Estimated H-index: 2
(Cornell University),
Javier A. Carrero24
Estimated H-index: 24
(WashU: Washington University in St. Louis)
+ 8 AuthorsJacqueline E. Payton25
Estimated H-index: 25
(WashU: Washington University in St. Louis)
Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded breaks (DSBs) in murine macrophage genomic DNA. In contrast to other cell types, initiation of this DDR depends on signaling from the type I interferon receptor. Once activated, ATM and DNA-PKcs regulate a genetic program with diverse immune functio...
Published on Dec 1, 2016in Current Opinion in Immunology7.67
Javier A. Carrero24
Estimated H-index: 24
(WashU: Washington University in St. Louis),
Stephen T. Ferris8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Emil R. Unanue84
Estimated H-index: 84
(WashU: Washington University in St. Louis)
Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an important homeostatic role in islet physiology. At the start of the autoimmune process in the NOD mouse, a small number of CD103+ dendritic cells (DC) are found at about the same tim...
Published on Jul 1, 2016in Journal of Autoimmunity7.54
Stephen T. Ferris8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Javier A. Carrero24
Estimated H-index: 24
(WashU: Washington University in St. Louis),
Emil R. Unanue84
Estimated H-index: 84
(WashU: Washington University in St. Louis)
Abstract This is a brief summary of our studies of NOD autoimmune diabetes examining the events during the initial stage of the process. Our focus has been on antigen presentation events and the antigen presenting cells (APC) inside islets. Islets of non-diabetic mice contain resident macrophages that are developmentally distinct from those in the inter-acinar stroma. The autoimmune process starts with the entrance of CD4+ T cells together with a burst of a subset of dendritic cells (DC) bearing...
Published on Jul 1, 2016in Immunological Reviews11.29
Emil R. Unanue84
Estimated H-index: 84
(WashU: Washington University in St. Louis),
Stephen T. Ferris8
Estimated H-index: 8
(WashU: Washington University in St. Louis),
Javier A. Carrero24
Estimated H-index: 24
(WashU: Washington University in St. Louis)
Summary We have been examining antigen presentation and the antigen presenting cells (APCs) in the islets of Langerhans of the non-obese diabetic (NOD) mouse. The purpose is to identify the earliest events that initiate autoimmunity in this confined tissue. Islets normally have a population of macrophages that is distinct from those that inhabit the exocrine pancreas. Also found in NOD islets is a minor population of dendritic cells (DCs) that bear the CD103 integrin. We find close interactions ...
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