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Javier A. Carrero
Washington University in St. Louis
59Publications
24H-index
3,729Citations
Publications 59
Newest
#1Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
#2N. Benshoff (WashU: Washington University in St. Louis)H-Index: 15
Last.Emil R. Unanue (WashU: Washington University in St. Louis)H-Index: 86
view all 4 authors...
The role of interferons, either pathogenic or protective, during autoimmune diabetes remains controversial. Herein, we examine the progression of diabetes in NOD mice lacking the type I (IFNAR) or type II (IFNGR) interferon receptor and, for the first time, in mice deficient in both receptors (double knockout [DKO]). All mice were bred, maintained, and monitored in a single specific pathogen-free facility with high female and low male diabetes incidence. Our expectation was that removal of inter...
1 CitationsSource
#1Bernd H. Zinselmeyer (WashU: Washington University in St. Louis)H-Index: 5
#2Anthony N. Vomund (WashU: Washington University in St. Louis)H-Index: 6
Last.Emil R. Unanue (WashU: Washington University in St. Louis)H-Index: 86
view all 6 authors...
Aims/hypothesis We studied here the interactions between the resident macrophages of pancreatic islets with beta cells and the blood vasculature. We also examined the immunological consequences of such interactions.
9 CitationsSource
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, to perform an important sentinel function. However, previous studies of DC function used markers, such as CD11c or CX3CR1, that are not unique to DCs. Here, we evaluated the role of DCs in renal inflammation using a CD11c reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46 -GFP and Snx22 -GFP. Multiphoton microscopy of kidney sections confirmed...
13 CitationsSource
#1Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
#2Derrick P. McCarthy (WashU: Washington University in St. Louis)H-Index: 1
Last.Emil R. Unanue (WashU: Washington University in St. Louis)H-Index: 86
view all 8 authors...
Abstract Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response, insulin content, and transcriptional profile. In NOD mice depleted of islet-resident macrophages starting at 3 wk of age, several changes occurred: (i) the early entrance...
21 CitationsSource
#1Stephen T. Ferris (WashU: Washington University in St. Louis)H-Index: 9
#2Pavel N. Zakharov (WashU: Washington University in St. Louis)H-Index: 2
Last.Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
view all 7 authors...
29 CitationsSource
#1Carolina Valderrama (National University of Colombia)H-Index: 2
#2Amy L. Clark (WashU: Washington University in St. Louis)H-Index: 9
Last.Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
view all 5 authors...
Type I interferons (IFNs) induce a detrimental response during Listeria monocytogenes (L. monocytogenes) infection. We were interested in identifying mechanisms linking IFN signaling to negative host responses against L. monocytogenes infection. Herein, we found that infection of myeloid cells with L. monocytogenes led to a coordinated induction of type I IFNs and activation of the integrated stress response (ISR). Infected cells did not induce Xbp1 splicing or BiP upregulation, indicating that ...
5 CitationsSource
#1Abigail J. Morales (Cornell University)H-Index: 2
#2Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
Last.Barry P. Sleckman (Cornell University)H-Index: 46
view all 11 authors...
Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded breaks (DSBs) in murine macrophage genomic DNA. In contrast to other cell types, initiation of this DDR depends on signaling from the type I interferon receptor. Once activated, ATM and DNA-PKcs regulate a genetic program with diverse immune functio...
9 CitationsSource
#1Abigail J. Morales (Cornell University)H-Index: 2
#2Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
Last.Barry P. Sleckman (Cornell University)H-Index: 46
view all 11 authors...
Source
#1Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
#2Stephen T. Ferris (WashU: Washington University in St. Louis)H-Index: 9
Last.Emil R. Unanue (WashU: Washington University in St. Louis)H-Index: 86
view all 3 authors...
Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an important homeostatic role in islet physiology. At the start of the autoimmune process in the NOD mouse, a small number of CD103+ dendritic cells (DC) are found at about the same tim...
4 CitationsSource
#1Stephen T. Ferris (WashU: Washington University in St. Louis)H-Index: 9
#2Javier A. Carrero (WashU: Washington University in St. Louis)H-Index: 24
Last.Emil R. Unanue (WashU: Washington University in St. Louis)H-Index: 86
view all 3 authors...
Abstract This is a brief summary of our studies of NOD autoimmune diabetes examining the events during the initial stage of the process. Our focus has been on antigen presentation events and the antigen presenting cells (APC) inside islets. Islets of non-diabetic mice contain resident macrophages that are developmentally distinct from those in the inter-acinar stroma. The autoimmune process starts with the entrance of CD4+ T cells together with a burst of a subset of dendritic cells (DC) bearing...
9 CitationsSource
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