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Yu Yi Fu
Nan Kai University of Technology
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#1Yu-Show Fu (NYMU: National Yang-Ming University)H-Index: 13
#2Yen Yang Lin (NYMU: National Yang-Ming University)H-Index: 1
Last.Jia Yi Wang (NDU: National Defense University)H-Index: 1
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We tested the herbal extract 2,3,5,6-tetramethylpyrazine (TMP) for possible therapeutic efficacy against a glioma cell line and against gliomas transplanted into rat brains. In the cultured glioma cells, 50 μM TMP significantly inhibited glutamate-induced increase in intracellular calcium. Significant cell damage (30%) and proliferation suppression (10%), however, occurred only at higher concentrations (200–400 μM). Glioma- neuronal co-culturing resulted in significant neuronal damage and higher...
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