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Igor M. Pongrac
University of Zagreb
Neural stem cellNanoparticleChemistryBiocompatibilitySilver nanoparticle
12Publications
4H-index
67Citations
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Publications 13
Newest
#1Ivan PavičićH-Index: 13
#2Mirta MilićH-Index: 15
Last. Ivana Vinković VrčekH-Index: 12
view all 10 authors...
Abstract Silver nanoparticles (AgNPs) represent one of the most abundant biocidal nanomaterials contained in more than 30% of nano-enabled consumer products and 75% of nanomedical products. The cumulative exposure of the general population may therefore reach critical and potentially hazardous levels. Due to data gaps on AgNP effects in humans, it is urgent to further evaluate their possible toxicity, particularly in vulnerable systems like the nervous one. As AgNPs may cross the blood brain and...
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This study was designed to evaluate the nano–bio interactions between endogenous biothiols (cysteine and glutathione) with biomedically relevant, metallic nanoparticles (silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs)), in order to assess the biocompatibility and fate of nanoparticles in biological systems. A systematic and comprehensive analysis revealed that the preparation of AgNPs and AuNPs in the presence of biothiols leads to nanoparticles stabilized with oxidized forms of biot...
1 CitationsSource
#1Igor M. Pongrac (University of Zagreb)H-Index: 4
#2Marina Dobrivojević Radmilović (University of Zagreb)H-Index: 2
Last. Srećko Gajović (University of Zagreb)H-Index: 17
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Magnetic resonance imaging (MRI) of superparamagnetic iron oxide-labeled cells can be used as a non-invasive technique to track stem cells after transplantation. The aim of this study was to (1) ev...
1 CitationsSource
#1Barbara PemH-Index: 1
#2Igor M. PongracH-Index: 4
Last. Ivana Vinković VrčekH-Index: 4
view all 9 authors...
Improvement in nanosafety is one of the major tasks for innovation force of nanotechology, which may be accomplished by design and development of biocompatible nanomaterials. Biocompatibility assessment demands investigation of nano-bio interactions that affect behavior and fate of nanoparticles in biological systems. Metallic nanoparticles (NPs) are particularly prone to interact with endogenous biothiols like cysteine and glutathione. This study was designed to evaluate intimate interactions b...
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#1Igor M. Pongrac (University of Zagreb)H-Index: 4
#2Lada Brkić Ahmed (University of Zagreb)H-Index: 4
Last. Ivana Vinković VrčekH-Index: 12
view all 9 authors...
Abstract The rapid development and widespread applications of nanotechnology necessitates the design towards safe nanoparticles. Surface structure is among the most important physicochemical characteristics of metallic nanoparticles affecting their mode of action in certain biological or environmental compartments. This study aimed to investigate how different surface coatings affect the cytotoxicity and cellular uptake of silver nanoparticles (AgNPs) in murine neural stem cells (mNSCs). Differe...
4 CitationsSource
#1Lada Brkić Ahmed (University of Zagreb)H-Index: 4
#2Mirta MilićH-Index: 15
Last. Ivana Vinković VrčekH-Index: 12
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Abstract Safe and successful bioapplications of metallic nanoparticles depend on their physicochemical characteristics, in particular their surface properties. This study aimed to investigate how different surface functionalization of silver nanoparticles (AgNP) affect their interaction with mammalian liver cells with regard to cytotoxicity, genotoxicity and mechanism of cellular uptake. Differentially coated AgNP were prepared by surface functionalization using sodium bis(2-ethylhexyl)-sulfosuc...
20 CitationsSource
#1Uliana Kostiv (CAS: Academy of Sciences of the Czech Republic)H-Index: 6
#2Vitalii Patsula (CAS: Academy of Sciences of the Czech Republic)H-Index: 5
Last. Daniel Horák (CAS: Academy of Sciences of the Czech Republic)H-Index: 32
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Monodisperse, superparamagnetic oleic acid-stabilized Fe3O4 nanoparticles of different sizes were prepared by thermal decomposition of Fe(III) oleate. The particles were subsequently coated by silica shells of different thicknesses (yielding Fe3O4&SiO2) using a water-in-oil (w/o) reverse microemulsion technique and/or were decorated with amino groups by reaction with (3-aminopropyl)triethoxysilane. The resulting Fe3O4&SiO2-NH2 nanoparticles were then modified with poly(ethylene glycol) (PEG) via...
10 CitationsSource
#1Igor M. PongracH-Index: 4
#2Ivan PavičićH-Index: 13
Last. Srećko
view all 11 authors...
BACKGROUND: Cell tracking is a powerful tool to understand cellular migration, dynamics, homing and function of stem cell transplants. Nanoparticles represent possible stem cell tracers, but they differ in cellular uptake and side effects. Their properties can be modified by coating with different biocompatible polymers. To test if a coating polymer, poly(L-lysine), can improve the biocompatibility of nanoparticles applied to neural stem cells, poly(L-lysine)-coated maghemite nanoparticles were ...
10 CitationsSource
Biocompatibility, safety, and risk assessments of superparamagnetic iron oxide nanoparticles (SPIONs) are of the highest priority in researching their application in biomedi- cine. One improvement in the biological properties of SPIONs may be achieved by different functionalization and surface modifications. This study aims to investigate how a different surface functionalization of SPIONs - uncoated, coated with d-mannose, or coated with poly- l-lysine - affects biocompatibility. We sought to i...
23 CitationsSource
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