Jiantao Ma
Tufts University
Publications 31
#1Tianxiao Huan (NIH: National Institutes of Health)H-Index: 22
#2Roby Joehanes (NIH: National Institutes of Health)H-Index: 23
Last.Melissa Richard (University of Texas Health Science Center at Houston)H-Index: 8
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Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-associated variants from genome-wide association studies (GWAS) may illuminate functional mechanisms underlying genetic variant-disease associations. Here, we perform GWAS of >415 thousand CpG methylation sites in whole blood from 4170 individuals and map 4.7 million cis- and 630 thousand trans-meQTL variants targeting >120 thousand CpGs. Independent replication is performed in 1347 participants from two s...
#1Jiantao Ma (Tufts University)H-Index: 10
#2Jana Nano (Erasmus University Medical Center)H-Index: 8
Last.Michael M. Mendelson (Boston Children's Hospital)H-Index: 12
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Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancestry (EA) participants and in 401 Hispanic ancestry and 724 African ancestry participants from four population-based cohort studies. Hepatic fat was measured using computed tomography or ultrasound imaging and DNA methylation was assessed at >400...
#1Rachel Hennein (NIH: National Institutes of Health)H-Index: 2
#2Chunyu Liu (BU: Boston University)H-Index: 50
Last.Jiantao Ma (Tufts University)H-Index: 10
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#1Michelle T. Long (BU: Boston University)H-Index: 11
#2Ellen B. Gurary (BU: Boston University)H-Index: 4
Last.Rohit Loomba (UCSD: University of California, San Diego)H-Index: 53
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#1Jiantao Ma (NIH: National Institutes of Health)H-Index: 10
#2Rachel Hennein (NIH: National Institutes of Health)H-Index: 2
Last.Douglas E. Levy (NIH: National Institutes of Health)H-Index: 191
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Background & Aims Dietary modification has been recommended for treatment of nonalcoholic fatty liver disease (NAFLD), although it is not clear whether improving diet quality can prevent its development. We performed a prospective study to examine the association between diet quality change and change in liver fat. We also examined the association between genetic risk score and liver fat change in individuals with different levels of diet quality change. Methods Our study included 1521 participa...
#1Rachel Hennein (NIH: National Institutes of Health)H-Index: 2
#2Susan Hwang (NIH: National Institutes of Health)H-Index: 57
Last.Jiantao Ma (NIH: National Institutes of Health)H-Index: 10
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#1Rachel HenneinH-Index: 2
#2Jiantao MaH-Index: 10
Last.Douglas E. LevyH-Index: 191
view all 5 authors...
Objectives: Visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) are associated with cardiometabolic diseases. The relationship between diet quality and abdominal fat accumulation, however, has not been well studied. We aimed to examine the long-term association of change in diet quality and change in abdominal adipose tissue. Methods: In 1,677 participants who attended two consecutive Framingham Heart Study examinations, we measured the volume of VAT and SAT using multi...
#1Nicola M. McKeown (Tufts University)H-Index: 36
#2Hassan S. Dashti (Broad Institute)H-Index: 10
Last.Denis Rybin (BU: Boston University)H-Index: 30
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Aims/hypothesis Sugar-sweetened beverages (SSBs) are a major dietary contributor to fructose intake. A molecular pathway involving the carbohydrate responsive element-binding protein (ChREBP) and the metabolic hormone fibroblast growth factor 21 (FGF21) may influence sugar metabolism and, thereby, contribute to fructose-induced metabolic disease. We hypothesise that common variants in 11 genes involved in fructose metabolism and the ChREBP-FGF21 pathway may interact with SSB intake to exacerbate...