Willie Hamilton
University of Exeter
CancerPathologyReferralFamily medicineMedicine
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Publications 345
#1David J. Keene (University of Oxford)H-Index: 7
#2Hessam Soutakbar (University of Oxford)H-Index: 1
Last. Sarah E Lamb (University of Oxford)H-Index: 49
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ABSTRACT Objectives The Getting it Right: Addressing Shoulder Pain (GRASP) trial is a large-scale, multicentre, 2 × 2 factorial randomised controlled trial investigating clinical and cost-effectiveness of a progressive exercise programme versus best-practice advice, with or without corticosteroid injection, for treating people with rotator cuff disorders. Here we describe the development, implementation and details of the physiotherapy-led interventions. Methods Medical Research Council guidance...
#1Marije A van Melle (University of Cambridge)
#1Sarah Er BaileyH-Index: 1
Last. Fiona M WalterH-Index: 34
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BACKGROUND: Recently, faecal immunochemical tests (FITs) have been introduced for investigation of primary care patients with low-risk symptoms of colorectal cancer (CRC), but recommendations vary across the world. This systematic review of clinical practice guidelines aimed to determine how FITs are used in symptomatic primary care patients and the underpinning evidence for these guidelines. METHODS: MEDLINE, Embase and TRIP databases were systematically searched, from 1 November 2008 to 1 Nove...
#2S. Bailey (University of Exeter)H-Index: 7
Last. Elizabeth A ShephardH-Index: 9
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Background Microcytosis (smaller than normal red blood cells) has previously been identified as a possible early risk marker for some cancers. However, the role of microcytosis across all cancers has not been fully investigated. Aim To examine cancer incidence in a cohort of patients with microcytosis, with and without accompanying anaemia. Design and setting Cohort study of patients aged ≥40 years using UK primary care electronic patient records. Method The 1-year cancer incidence was compared ...
#1Yin Zhou (University of Cambridge)H-Index: 5
#2Gary A. Abel (University of Exeter)H-Index: 30
Last. Georgios Lyratzopoulos (UCL: University College London)H-Index: 35
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INTRODUCTION: Sub-optimal use or interpretation of imaging investigations prior to diagnosis of certain cancers may be associated with less timely diagnosis, but pre-diagnostic imaging activity for urological cancer is unknown. METHOD: We analysed linked data derived from primary and secondary care records and cancer registration to evaluate the use of clinically relevant imaging tests pre-diagnosis, in patients with bladder and kidney cancer diagnosed in 2012-15 in England. As pre-diagnostic im...
#1Brian D Nicholson (University of Oxford)H-Index: 7
#2Willie Hamilton (University of Exeter)H-Index: 59
Last. Paul Aveyard (University of Oxford)H-Index: 47
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BACKGROUND: We aimed to understand the time period of cancer diagnosis and the cancer types detected in primary care patients with unexpected weight loss (UWL) to inform cancer guidelines. METHODS: This retrospective matched cohort study used cancer registry linked electronic health records from the UK's Clinical Practice Research Datalink from between 2000 and 2014. Univariable and multivariable time-to-event analyses examined the association between UWL, and all cancers combined, cancer site a...
1 CitationsSource
#1Jessica WatsonH-Index: 8
#2Penny Whiting (UoB: University of Bristol)H-Index: 35
Last. Willie Hamilton (University of Exeter)H-Index: 59
view all 5 authors...
#1Sarah Chowienczyk (University of Exeter)
#2Sarah J Price (University of Exeter)H-Index: 5
Last. Willie Hamilton (University of Exeter)H-Index: 59
view all 3 authors...
Background Most patients diagnosed with lung cancer present with symptoms. It is not known if the proportions of patients presenting with each symptom has changed over time. Identifying trends in lung cancer’s presenting symptoms is important for medical education and early-diagnosis initiatives. Aim To identify the first reported symptom of possible lung cancer (index symptom), and to test whether the percentages of patients with each index symptom changed during 2000–2017. Design and setting T...
#1Clare PearsonH-Index: 6
#1Clare PearsonH-Index: 1
Last. Willie Hamilton (University of Exeter)H-Index: 59
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Introduction Patients presenting to primary care with site-specific alarm symptoms can be referred onto urgent suspected cancer pathways, whereas those with non-specific symptoms currently have no dedicated referral routes leading to delays in cancer diagnosis and poorer outcomes. Pilot Multidisciplinary Diagnostic Centres (MDCs) provide a referral route for such patients in England. Objectives This work aimed to use linked primary care and cancer registration data to describe diagnostic pathway...
#1Stephen Bradley (University of Leeds)H-Index: 1
#2Sarah AbrahamH-Index: 1
Last. Richard D Neal (University of Leeds)H-Index: 36
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Background Despite increasing use of computed tomography (CT), chest X-ray remains the first-line investigation for suspected lung cancer in primary care in the UK. No systematic review evidence exists as to the sensitivity of chest X-ray for detecting lung cancer in people presenting with symptoms. Aim To estimate the sensitivity of chest X-ray for detecting lung cancer in symptomatic people. Design and setting A systematic review was conducted to determine the sensitivity of chest X-ray for th...
#1Brian D Nicholson (University of Oxford)H-Index: 7
#2Paul Aveyard (University of Oxford)H-Index: 47
Last. Sarah Lay-Flurrie (University of Oxford)H-Index: 1
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Background Excess weight and unexpected weight loss are associated with multiple disease states and increased morbidity and mortality, but weight measurement is not routine in many primary care settings. The aim of this study was to characterise who has had their weight recorded in UK primary care, how frequently, by whom and in relation to which clinical events, symptoms and diagnoses.
3 CitationsSource