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Willie Hamilton
University of Exeter
380Publications
56H-index
51.9kCitations
Publications 380
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One in three colon cancers are diagnosed as an emergency, which is associated with worse cancer outcomes. Chronic conditions (comorbidities) affect large proportions of adults and they might influence the risk of emergency presentations (EP). We aimed to evaluate the effect of specific pre-existing comorbidities on the risk of colon cancer being diagnosed following an EP rather than through non-emergency routes. The cohort study included 5745 colon cancer patients diagnosed in England 2005–2010,...
#1Karolis Zienius (Edin.: University of Edinburgh)H-Index: 2
#2Ip Chak-Lam (Edin.: University of Edinburgh)
Last.Edna Keeney (UoB: University of Bristol)H-Index: 4
view all 10 authors...
Background Brain tumour patients see their primary care doctor on average three or more times before diagnosis, so there may be an opportunity to identify ‘at risk’ patients earlier. Suspecting a brain tumour diagnosis is difficult because brain tumour-related symptoms are typically non-specific.
#1Fiona M Walter (University of Cambridge)H-Index: 33
#2Matthew Thompson (UW: University of Washington)H-Index: 43
Last.Greg Rubin (RVI: Royal Victoria Infirmary)H-Index: 21
view all 10 authors...
Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, ...
#1Brian D Nicholson (University of Oxford)H-Index: 6
#2Paul Aveyard (University of Oxford)H-Index: 46
Last.Marites Derit (University of Oxford)H-Index: 44
view all 4 authors...
### What you need to know Unexpected weight loss presents a diagnostic challenge in primary care. It is associated with a wide range of benign and serious conditions (box 1).1 Box 1 ### Differential diagnosis for patients with unexpected weight loss1RETURN TO TEXT Weight loss may be missed or misattributed because of several factors (see box 2). Once it is detected, the uncertainty for clinicians is not about whether unexpected weight loss is a symptom of concern, it is about who should be inves...
#1Samuel W D Merriel (University of Exeter)H-Index: 3
#2Victoria Hardy (University of Cambridge)
Last.Willie Hamilton (University of Exeter)H-Index: 56
view all 5 authors...
Abstract Objective To identify and characterize patient-centered outcomes (PCOs) relating to multiparametric MRI (mpMRI) and MRI-guided biopsy as diagnostic tests for possible prostate cancer. Methods Medline via OVID, EMBASE, PsycInfo, and the Cochrane Central register of Controlled Trials (CENTRAL) were searched for relevant articles. Hand searching of reference lists and snowballing techniques were performed. Studies of mpMRI and MRI-guided biopsy that measured any PCO were included. There we...
#1Tamsin V Newlove-Delgado (University of Exeter)H-Index: 5
#2Willie Hamilton (University of Exeter)H-Index: 56
Last.Obioha C. Ukoumunne (University of Exeter)H-Index: 49
view all 5 authors...
Guidance on management of attention deficit hyperactivity disorder (ADHD) in the UK was issued by the National Institute for Clinical Excellence in 2008. No UK study has examined all psychotropic prescribing in young people with ADHD since the introduction of the guidance; this is especially relevant due to the high prevalence of psychiatric comorbidity in this population. The aim of this study was to describe primary care prescribing of ADHD and other psychotropic medications for young people w...
#1Cristina Renzi (UCL: University College London)H-Index: 10
#2A Kaushal (UCL: University College London)H-Index: 2
Last.Niek J. de Wit (UU: Utrecht University)H-Index: 28
view all 10 authors...
An earlier diagnosis is a key strategy for improving the outcomes of patients with cancer. However, achieving this goal can be challenging, particularly for the growing number of people with one or more chronic conditions (comorbidity/multimorbidity) at the time of diagnosis. Pre-existing chronic diseases might affect patient participation in cancer screening, help-seeking for new and/or changing symptoms and clinicians’ decision-making on the use of diagnostic investigations. Evidence suggests,...
#1Jessica Watson (NIHR: National Institute for Health Research)H-Index: 7
#2Chris Salisbury (NIHR: National Institute for Health Research)H-Index: 44
Last.Willie Hamilton (University of Exeter)H-Index: 56
view all 6 authors...
Background Inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, and plasma viscosity) are commonly used in primary care. Though established for specific diagnostic purposes, there is uncertainty around their utility as a non-specific marker to rule out underlying disease in primary care. Aim To identify the value of inflammatory marker testing in primary care as a rule-out test, and measure the cascade effects of testing in terms of further blood tests, GP appointments, and ...
#1David J. Keene (University of Oxford)H-Index: 7
#2Hessam Soutakbar (University of Oxford)H-Index: 1
Last.Andrew Carr (University of Oxford)H-Index: 92
view all 10 authors...
ABSTRACT Objectives The Getting it Right: Addressing Shoulder Pain (GRASP) trial is a large-scale, multicentre, 2 × 2 factorial randomised controlled trial investigating clinical and cost-effectiveness of a progressive exercise programme versus best-practice advice, with or without corticosteroid injection, for treating people with rotator cuff disorders. Here we describe the development, implementation and details of the physiotherapy-led interventions. Methods Medical Research Council guidance...
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