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Marek Langner
Wrocław University of Technology
80Publications
15H-index
888Citations
Publications 77
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Background: Liposomes serve as delivery systems for biologically active compounds. Existing technologies inefficiently encapsulate large hydrophilic macromolecules, such as PVP-conjugated chlorin e6 (Photolon). This photoactive drug has been widely tested for therapeutic applications, including photodynamic reduction of atherosclerotic plaque. Methods: A novel formulation of Photolon was produced using “gel hydration technology”. Its pharmacokinetics was tested in Sus scrofa f. domestica. Its ce...
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AbstractVitamin C is the exogenous compound necessary for a variety of metabolic processes; therefore, the efficient delivery is critical for the maintenance of body homeostasis. Vitamin C pharmacokinetics and low quantities in processed foodstuff, necessitates its continuous supplementation. In the paper, we present the new liposomal formulation of vitamin C free of harmful organic solvents. The formulation was quantitatively characterized with respect to its chemically composition and nano-str...
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#1Joanna DoskoczH-Index: 1
#2Dominik DrabikH-Index: 4
Last.Marek LangnerH-Index: 15
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Bending rigidity coefficient describes propensity of a lipid bilayer to deform. In order to measure the parameter experimentally using flickering noise spectroscopy, the microscopic imaging is required, which necessitates the application of giant unilamellar vesicles (GUV) lipid bilayer model. The major difficulty associated with the application of the model is the statistical character of GUV population with respect to their size and the homogeneity of lipid bilayer composition, if a mixture of...
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#1Kamila SzostakH-Index: 1
#2Aleksander Czogalla (UWr: University of Wrocław)H-Index: 15
Last.Marek LangnerH-Index: 15
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AbstractOctenidine dihydrochloride is an effective antiseptic compound which mode of action is based on destabilization plasma membrane of microorganisms. This ensures that microorganisms cannot develop the drug resistance in a straightforward way, as the entire cellular structure, rather than specific molecular target is affected. Since the octenidine is a hydrophobic compound, it requires organic solvent such as phenoxyethanol in order to be effectively administered. However, the presence of p...
3 CitationsSource
#1Magda PrzybyłoH-Index: 6
#2Dominik DrabikH-Index: 4
Last.Marek LangnerH-Index: 15
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Abstract Organotin compounds, being biologically active, affect a variety of cellular functions due to their ability to accumulate in and penetrate biological membranes. These compounds influence the distribution of electrostatic charges, alter organization, disrupt molecular dynamics and change mechanical properties of biological membranes. It was found that the membrane/water partition coefficient equals 4, a value significantly higher than octanol/water partition coefficient. In addition, the...
1 CitationsSource
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#2Tomasz BorowikH-Index: 8
Last.Marek LangnerH-Index: 15
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#1Dominik Drabik (Wrocław University of Technology)H-Index: 4
#2Magda Przybyło (Wrocław University of Technology)H-Index: 6
Last.Marek Langner (Wrocław University of Technology)H-Index: 15
view all 4 authors...
Fluorescence Correlation Spectroscopy (FCS) is a technique, which allows determination of the diffusion coefficient and concentration of fluorescent objects suspended in the solution. The measured parameter is the fluctuation of the fluorescence signal emitted by diffusing molecules. When 100 nm DOPC vesicles labeled with various fluorescent dyes (Fluorescein-PE, NBD-PE, Atto488 DOPE or βBodipy FL) were measured, different values of diffusion coefficients have been obtained. These diffusion coef...
1 CitationsSource
#1Magdalena Przybyło (Wrocław University of Technology)H-Index: 4
#2Daria Głogocka (Wrocław University of Technology)H-Index: 1
Last.Marek Langner (Wrocław University of Technology)H-Index: 15
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The proper lipid composition of liposomes designed to carry drugs determines their surface properties ensuring their accumulation within selected tissue. The electrostatic potential and surface topology of liposomes affect the internalization by single cells. The high-resolution imaging of cancer cells and the distribution of protoporphyrin-loaded liposomes within the cytoplasm and its dependence on the liposome surface properties are presented. In the paper, HeLa cells were used to investigate ...
10 CitationsSource
#1Dominik Drabik (Wrocław University of Technology)H-Index: 4
#2Magda Przybyło (Wrocław University of Technology)H-Index: 6
Last.Marek Langner (Wrocław University of Technology)H-Index: 15
view all 5 authors...
Lipid bilayer is the main constitutive element of biological membrane, which confines intracellular space. The mechanical properties of biological membranes may be characterized by various parameters including membrane stiffness or membrane bending rigidity, which can be measured using flicker noise spectroscopy. The flicker noise spectroscopy exploits the spontaneous thermal undulations of the membrane. The method is based on the quantitative analysis of a series of microscopic images captured ...
9 CitationsSource
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