Antonio Claudio Tedesco
University of São Paulo
ChemistryDrug deliveryPhotodynamic therapyPhotosensitizerPhotochemistry
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Publications 312
#1Italo Rodrigo Calori (USP: University of São Paulo)H-Index: 2
Last. Antonio Claudio TedescoH-Index: 37
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Abstract Up-regulated monocarboxylate transporters (MCTs) serve as potential targets for the development of novel therapeutic strategies against some cancer cells. Besides being an efficient substrate to some MCTs, the role of alpha-cyano-4-hydroxycinnamic acid (CHCA) as a vector of nanoparticles for cancer cells was not yet evaluated. This aim of this study was to demonstrate the role of CHCA as a vector of liposomes targeting cancer cells that overexpress MCT-1. Also, the antioxidant character...
#2Haizhen DingH-Index: 1
Last. Hong BiH-Index: 1
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Here we report a novel strategy to crosslink the surface of sulfonated-CDs (S-CDs) by complexing SnCl4 with sulfonate groups (-SO3-) into aqueous solution. The S-CDs show an average photoluminescence (PL) quantum yield of 21% and a mean diameter of 3.8 nm. After complexed with the Sn4+, the as-obtained Sn@S-CDs present a reduced size of 1.8 nm as well as a higher PL quantum yield of 32%. More interestingly, the Sn@S-CDs show an enhanced singlet oxygen (1O2) quantum yield as high as 37% compared ...
#1Italo Rodrigo Calori (USP: University of São Paulo)H-Index: 2
#2Gustavo BragaH-Index: 4
Last. Antonio Claudio Tedesco (USP: University of São Paulo)H-Index: 37
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Abstract Drug delivery scaffolds are smart alternatives to conventional formulations and allow for controlled spatiotemporal releases of active compounds. In several fields of human health, various methods have emerged with natural and synthetic polymers that make the fabrication of new polymer scaffolds possible. This review provides an overview of all recently published studies on the development and application of polymer scaffolds targeting controlled drug delivery in medicinal fields, inclu...
1 CitationsSource
#1Italo Rodrigo Calori (USP: University of São Paulo)H-Index: 2
Last. Noboru HiokaH-Index: 20
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Abstract Stealth strategies have improved some properties of drug nanocarriers, including circulation time in vivo and kinetic stability, which led to the novel-generation of stealth liposomes. Among these, Pluronic®/lipid mixtures provide one of the simplest and lowest-cost stealth liposomes, although the formation of Pluronic micelles above its critical micelle temperature (CMT) concurrently lead to undesirable effects in a drug-carrier approach. Recently, we proposed a fluorometric method to ...
#1Laise Rodrigues de Andrade (UnB: University of Brasília)H-Index: 1
#2Antonio Claudio Tedesco (USP: University of São Paulo)H-Index: 37
Last. Willie O Pinheiro (UnB: University of Brasília)
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Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, th...
#1Zhenzhen LiH-Index: 1
#2Dong WangH-Index: 1
Last. Hong BiH-Index: 9
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Recently, graphene quantum dots (GQDs) have been extensively studied in biomedical areas such as bio-imaging, bio-sensing and photothermal therapy due to their superior optical and physiochemical properties compared to traditional organic biomarkers. Application of GQDs in photodynamic therapy (PDT) has been explored since 2014, but currently the main challenges are inadequate singlet oxygen (1O2) quantum yield (QY), poor solubility and biocompatibility. Herein, we report on the synthesis of a n...
#1Leonardo Lobo Ribeiro Cavalcante (USP: University of São Paulo)
#2Antonio Claudio Tedesco (USP: University of São Paulo)H-Index: 37
Last. Silmara Aparecida Milori Corona (USP: University of São Paulo)H-Index: 24
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BACKGROUND: Antimicrobial photodynamic therapy (aPDT) using chloroaluminium phthalocyanine (ClAlPc) has high oxidative power, being an alternative for the control of biofilms, especially when the photosensitizer is administered in an appropriate release vehicle. This study aimed to develop/characterize the ClAlPc encapsulated in chitosan nanoparticles (CSNPs), and evaluate its antimicrobial properties against S. mutans biofilms. METHODS: CSNPs were prepared by ion gelation, and characterization ...
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#1Tairine Zara Lopes (UNESP: Sao Paulo State University)H-Index: 1
#2Fabio Rogerio de Moraes (UNESP: Sao Paulo State University)H-Index: 4
Last. Marilia de Freitas Calmon (UNESP: Sao Paulo State University)H-Index: 12
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Abstract Renal cell carcinoma (RCC) consists of the most lethal common urological cancer and the clinical practice has shown that resistant RCC to commons therapies is extremely high. Berberine is an isoquinoline alkaloid, presents in different kinds of plants and it has long been used in Chinese medicine. It has several properties, such as antioxidant, anti-inflammatory, anti-diabetic, anti-microbial and anti-cancer. Moreover, berberine has photosensitive characteristics and its association wit...
4 CitationsSource