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Qing Li
University of Bremen
17Publications
9H-index
356Citations
Publications 17
Newest
Published on Jan 1, 2019in Analytical Methods 2.38
Jingfeng Li16
Estimated H-index: 16
(University of Bremen),
Qing Li9
Estimated H-index: 9
(University of Bremen)
+ 2 AuthorsColombi Ciacchi Lucio (University of Bremen)
Atomic-force-microscopy-based single-molecule force spectroscopy (AFM-SMFS) has become an important technique as the basis of novel, label-free biosensing strategies. In this work, we explored the possibility of using AFM-SMFS to detect the specific peptide cleavage activity by thrombin proteases. To achieve this aim, an oligopeptide with a sequence that is recognized and cleaved by thrombin was spanned between an AFM tip and a solid surface via a PEG-based linker system including the stable bio...
Published on Jan 1, 2018in Analyst 4.02
Qing Li9
Estimated H-index: 9
(University of Bremen),
Gang Wei36
Estimated H-index: 36
(University of Bremen)
Single molecule force spectroscopy based on atomic force microscopy (AFM) is a simple and sensitive technique to probe molecular recognition forces. Here we demonstrate that visual color-intensity analysis of single molecule force mapping (SMFM) can be employed as a quick and convenient force-to-color detection towards the presence of various dissolved analytes in very low concentrations. To achieve this aim, analyte-specific single-strand DNA aptamers are first bound to an AFM tip. The measured...
Published on Jan 1, 2017in RSC Advances 3.05
Yizhou Huang2
Estimated H-index: 2
(Huada: Beijing University of Chemical Technology),
Yazhou Tian2
Estimated H-index: 2
(Huada: Beijing University of Chemical Technology)
+ 4 AuthorsJunying Zhang15
Estimated H-index: 15
(Huada: Beijing University of Chemical Technology)
A series of epoxy systems with tunable rigid-flexibility were prepared by the curing reaction of bisphenol F diglycidyl (DGEBF), a single-ended amine with alkyl chains (n-butyl, octyl, dodecyl), 4,4′-diaminodiphenylmethane (DDM) and 4,4′-diaminodicyclohexylmethane (H-DDM). By means of adjusting the composition of the curing agent (the molar ratio between H-DDM and DDM), nano- and submicron-sized phase separations were observed by atomic force microscopy (AFM). And diffraction peaks were not obse...
Published on Jan 1, 2016in RSC Advances 3.05
Qing Li9
Estimated H-index: 9
(University of Bremen),
Tong Zhang2
Estimated H-index: 2
(UGA: University of Georgia)
+ 3 AuthorsGang Wei36
Estimated H-index: 36
(University of Bremen)
The interactions between biomolecules and material interfaces at the molecular level are complicated but very important for the development of materials science, nanotechnology, biophysics, biomedicine, and analytical science. Atomic force microscopy-based force spectroscopy (AFM-FS) is a useful technique for directly measuring the interactions between biomolecules and different material interfaces from the hard inorganic surfaces to the soft bio-substrates. In this review, we summarize recent s...
Published on Mar 19, 2015in Biosensors
Jingfeng Li16
Estimated H-index: 16
(University of Bremen),
Qing Li9
Estimated H-index: 9
(University of Bremen)
+ 1 AuthorsGang Wei36
Estimated H-index: 36
(University of Bremen)
We demonstrate a simple force-based label-free strategy for the highly sensitive sensing of adenosine. An adenosine ssDNA aptamer was bound onto an atomic force microscopy (AFM) probe by covalent modification, and the molecular-interface adsorption force between the aptamer and a flat graphite surface was measured by single-molecule force spectroscopy (SMFS). In the presence of adenosine, the molecular recognition between adenosine and the aptamer resulted in the formation of a folded, hairpin-l...
Published on Jan 1, 2015in Analyst 4.02
Qing Li9
Estimated H-index: 9
(University of Bremen),
Monika Michaelis2
Estimated H-index: 2
(University of Bremen)
+ 1 AuthorsLucio Colombi Ciacchi20
Estimated H-index: 20
(University of Bremen)
We have developed a novel aptasensor based on single-molecule force spectroscopy (SMFS) capable of detecting mercury ions (Hg2+) with sub-nM sensitivity. The single-strand (ss) DNA aptamer used in this work is rich in thymine (T) and readily forms T–Hg2+–T complexes in the presence of Hg2+. The aptamer was conjugated to an atomic force microscope (AFM) probe, and the adhesion force between the probe and a flat graphite surface was measured by single-molecule force spectroscopy (SMFS). The presen...
Published on Jan 1, 2015in Biomaterials Science 5.25
Panpan Zhang12
Estimated H-index: 12
(Huada: Beijing University of Chemical Technology),
Haixia Wang8
Estimated H-index: 8
(Huada: Beijing University of Chemical Technology)
+ 5 AuthorsZhiqiang Su29
Estimated H-index: 29
(Huada: Beijing University of Chemical Technology)
Graphene and silver nanoparticles (AgNPs) are important building blocks for the synthesis of functional nanomaterials for bio-related applications. Here, we report a facile strategy to decorate AgNPs onto reduced graphene oxide (RGO) by the simultaneous reduction of silver ions and graphene oxide nanosheets within one system, and further to fabricate a dimension-adjustable RGO/AgNP multi-layered film by a thermal-driven self-assembly process. The structures of the fabricated RGO/AgNP hybrid film...
Published on Jan 1, 2015in RSC Advances 3.05
Junwei Ding7
Estimated H-index: 7
(Huada: Beijing University of Chemical Technology),
Shiying Zhu1
Estimated H-index: 1
(Huada: Beijing University of Chemical Technology)
+ 4 AuthorsZhiqiang Su29
Estimated H-index: 29
(Huada: Beijing University of Chemical Technology)
We report here a facile synthesis of different zinc oxide (ZnO) nanostructures on reduced graphene oxide (RGO) by an in situ hydrothermal reaction. ZnO nanostructures with different morphologies on the surface of RGO were successfully synthesized by adjusting the mass ratio of Zn2+ to RGO in this reaction system. It was found that ZnO nanostructures with nanoparticles, mixed nanoparticles and microspindles, and microspindles were formed on RGO by adjusting the mass ratio of Zn2+ to RGO. The synt...
Published on Sep 1, 2014in Polymer Engineering and Science 1.92
Qing Li9
Estimated H-index: 9
(Huada: Beijing University of Chemical Technology),
Xiaoyuan Zhang5
Estimated H-index: 5
(Huada: Beijing University of Chemical Technology)
+ 4 AuthorsZhiqiang Su29
Estimated H-index: 29
(Huada: Beijing University of Chemical Technology)
We report here the synthesis and characterization of a reactive liquid crystal (RLC) as a novel polymeric nucleating agent for the promotion of the nucleation efficiency of isotactic polypropylene (iPP). The RLC was synthesized by an in-situ photo-polymerization and was then grafted onto the molecular chain of iPP by the reactive blending. The phase transition and crystalline morphologies of RLC-iPP in the β-nucleation were studied. It is found that the nucleation efficiency of β-crystals of iPP...
Published on Jan 1, 2014in Physical Chemistry Chemical Physics 3.57
Gang Wei36
Estimated H-index: 36
(University of Bremen),
Qing Li9
Estimated H-index: 9
(University of Bremen)
+ 1 AuthorsLucio Colombi Ciacchi20
Estimated H-index: 20
(University of Bremen)
We report here a systematic investigation of the interactions between two heteropolymer DNA single-strands (ssDNA) and graphite surfaces using AFM-based single-molecule force spectroscopy (SMFS). For this purpose, force-displacement (FD) curves are recorded by peeling single-molecule ssDNA from graphite. We find that the unbinding forces are affected both by the DNA sequences and the ionic strength of the liquid environment. In particular, the unbinding force decreases with the increase of ionic...
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