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Prasad A. Thakurdesai
Bharati Vidyapeeth University
EndocrinologyTrigonellaDiabetes mellitusMedicinePharmacology
72Publications
18H-index
1,100Citations
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Publications 72
Newest
#1Amit D. KandhareH-Index: 31
Last. Subhash L. Bodhankar (Poona College of Arts Science & Commerce)H-Index: 36
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Abstract Fenugreek (Trigonella foenum graecum) seed extract is a bioactive ingredient of many food supplements. Hence, there is a need for systematic assessment of the quality of published toxicological studies for its use in human health, hazard consideration, and risk assessment. The aim of the present investigation was to determine the reliability of published toxicological studies of fenugreek seed by using ToxRTool (Toxicological data reliability assessment tool). A comprehensive systematic...
1 CitationsSource
#1Amit D. KandhareH-Index: 31
#2Debasish Bandyopadhyay (College of Science and Technology)H-Index: 19
Last. Prasad A. ThakurdesaiH-Index: 18
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Background: Obesity is a complex, chronic metabolic disorder and its prevalence is increasing throughout most of the world. Low molecular weight galactomannans-based standardized fenugreek seed extract (LMWGAL-TF) has previously shown anti-diabetic and anti-hyperlipidemic potential. Aim: To evaluate the efficacy and mechanism of action of LMWGAL-TF in treating high fat diet (HFD)-induced obesity and hyperlipidemia in mice. Materials and methods: Male C57BL/6 mice were fed the HFD for 12 weeks an...
1 CitationsSource
#1Amit D. KandhareH-Index: 31
#2Uday Phadke (Ruby Hall Clinic)H-Index: 2
Last. Sunil BhaskaranH-Index: 2
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Objective: To assess the safety and efficacy of herbal formulation rich in standardized fenugreek seed extract (IND-2) add-on therapy in type 2 diabetes mellitus (T2DM) patients who were on insulin treatment in prospective, single arm, open-label, uncontrolled, multicentre trial. Methods: T2DM patients (n=30) with aged 18-80 years who were stabilized on insulin treatment with fasting blood sugar (FBS) level between 100-140 mg/dL received IND-2 capsules (700 mg, thrice a day) for 16 weeks. The pr...
2 CitationsSource
#1Amit D. KandhareH-Index: 31
#2Nadeem RaisH-Index: 1
Last. Sunil BhaskaranH-Index: 2
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Background: Type 2 diabetes mellitus (T2DM) is a chronic, complex, and progressive illness that often needs combination therapy for better glycemic control. IDM1, an herbal formulation which is rich in standardized fenugreek seed extract. Aim: The aim of this study is to evaluate the efficacy and safety of add-on therapy of IDM1 in T2DM patients inadequately controlled on sulfonylurea monotherapy. Materials and Methods: In this 12-week, randomized, double-blind, placebo-controlled, multi-centric...
3 CitationsSource
Source
#1Amit D. KandhareH-Index: 31
#2Urmila AswarH-Index: 8
Last. Prasad A. ThakurdesaiH-Index: 18
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: Allergic diseases are a significant health concern in developing countries. Type-A procyanidin polyphenols from cinnamon (Cinnamomum zeylanicum Blume) bark (TAPP-CZ) possesses antiasthmatic and antiallergic potential. The present study was aimed at the possible anti-allergic mechanism of TAPP-CZ against the compound 48/80 (C48/80)-induced mast cell degranulation in isolated rat peritoneal mast cells (RPMCs). TAPP-CZ (1, 3, 10, and 30 µg/ml) was incubated for 3 hours with isolated, purified RPM...
4 CitationsSource
#1Colin Wilborn (University of Mary Hardin–Baylor)H-Index: 22
#2Sara Hayward (University of Mary Hardin–Baylor)H-Index: 7
Last. Prasad A. ThakurdesaiH-Index: 18
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Objective: To assess the efficacy of a proprietary blend rich in glycoside based standardized fenugreek seed extract (400 mg) and minor quantities of curcumin and cinnamon (25 mg each) supplementation (IBPR) on inflammatory markers related to skeletal muscle soreness using double-blind placebo control, parallel design. Methods: A total of 20 healthy non-resistance trained young male and female subjects were assigned to ingest either IBPR or matching placebo for 14 days before the eccentric exerc...
1 CitationsSource
#1Amit D. Kandhare (Poona College of Arts Science & Commerce)H-Index: 31
#2Subhash L. Bodhankar (Poona College of Arts Science & Commerce)H-Index: 11
Last. Prasad A. ThakurdesaiH-Index: 18
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Background: Liver fibrosis a complex process of excess collagen deposition resulted in disturbance of hepatic cellar function. Glycosides based standardized fenugreek seed extract (SFSE-G) has potent anti-inflammatory, antioxidant, and anti-fibrotic properties. Objective: The aim of this study is to evaluate the hepatoprotective potential of SFSE-G against bleomycin (BLM)-induced liver fibrosis in laboratory animals. Materials and Methods: Sprague-Dawley rats (180–220 g) were assigned to various...
4 CitationsSource
#1Pallavi DeshpandeH-Index: 4
#2Vishwaraman MohanH-Index: 14
Last. Prasad A. ThakurdesaiH-Index: 18
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Objective: To evaluate acute oral toxicity (AOT), subchronic (90-day repeated dose) toxicity, mutagenicity, and genotoxicity potential of IDM01, the botanical composition of 4-hydroxyisoleucine- and trigonelline-based standardized fenugreek ( Trigonella foenum-graecum L) seed extract in laboratory rats. Materials and Methods: The AOT and subchronic (90-day repeated dose) toxicity were evaluated using Sprague-Dawley rats as per the Organisation for Economic Co-operation and Development (OECD) gui...
2 CitationsSource
#1Pallavi DeshpandeH-Index: 4
#2Vishwaraman MohanH-Index: 14
Last. Prasad A. ThakurdesaiH-Index: 18
view all 5 authors...
Context: Glycoside-based standardized fenugreek seed extract (SFSE-G) demonstrated promising efficacy in animal models of immune-inflammatory conditions. Aim : The present study was aimed at embryo-fetal development toxicity evaluation of SFSE-G in Wistar rats as per guideline No. 414 of the Organization for Economic Co-operation and Development (OECD). Material and Methods: Mated female rats were randomized into four groups of 30 each and received oral doses of either SFSE-G at 250, 500, and 10...
4 CitationsSource
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