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Flurin Item
Boston Children's Hospital
12Publications
9H-index
255Citations
Publications 12
Newest
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Céline I. Laesser (Boston Children's Hospital)H-Index: 1
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 9 authors...
We recently showed that interleukin (IL)-6-type cytokine signaling in adipocytes induces free fatty acid release from visceral adipocytes, thereby promoting obesity-induced hepatic insulin resistance and steatosis. In addition, IL-6-type cytokines may increase the release of leptin from adipocytes and by those means induce glucagon-like peptide 1 (GLP-1) secretion. We thus hypothesized that IL-6-type cytokine signaling in adipocytes may regulate insulin secretion. To this end, mice with adipocyt...
10 CitationsSource
#1Flurin Item (Boston Children's Hospital)H-Index: 9
#2Stephan Wueest (Boston Children's Hospital)H-Index: 15
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 17 authors...
Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death receptor (Fas/CD95/Apo-1) regulates hepatic mitochondrial metabolism. Hepatic Fas overexpression in chow-fed mice compromises fatty acid oxidation, mitochondrial respiration, and the abundance of mitoc...
10 CitationsSource
#1Erez DrorH-Index: 7
#2Elise DalmasH-Index: 8
Last.Marc Y. DonathH-Index: 60
view all 20 authors...
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
70 CitationsSource
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Flurin Item (Boston Children's Hospital)H-Index: 9
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 7 authors...
Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and tightly associated with obesity and type 2 diabetes. However, underlying mechanism linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. Glycoprotein 130 (gp130) is the common signal transducer of all interleukin 6 (IL-6) cytokines. Herein, we provide evidence that gp130-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. In ob...
34 CitationsSource
#1Siew Hung Chin (UZH: University of Zurich)H-Index: 2
#2Flurin Item (Boston Children's Hospital)H-Index: 9
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 10 authors...
Reduced kidney mass and/or function may result in multiple metabolic derangements, including insulin resistance. However, underlying mechanisms are poorly understood. Herein, we aimed to determine the impact of reduced kidney mass on glucose metabolism in lean and obese mice. To that end, seven-week-old C57BL6/J mice underwent uninephrectomy (UniNx) or sham operation. After surgery, animals were fed either a chow (standard) or a high fat diet (HFD) and glucose homeostasis was assessed 20 weeks a...
5 CitationsSource
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Flurin Item (Boston Children's Hospital)H-Index: 9
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 13 authors...
Contracting muscle releases interleukin-6 (IL-6) enabling the metabolic switch from carbohydrate to fat utilization. Similarly, metabolism is switched during transition from fed to fasting state. Herein, we examined a putative role for IL-6 in the metabolic adaptation to normal fasting. In lean C57BL/6J mice, 6 h of food withdrawal increased gene transcription levels of IL-6 in skeletal muscle but not in white adipose tissue. Concomitantly, circulating IL-6 and free fatty acid (FFA) levels were ...
22 CitationsSource
#1Michael Sf Wiedemann (UZH: University of Zurich)H-Index: 1
#2Stephan Wueest (Boston Children's Hospital)H-Index: 15
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 6
view all 6 authors...
A short bout of high fat diet (HFD) impairs glucose tolerance and hepatic insulin sensitivity. We recently identified adipose tissue inflammation and resulting dysfunctional adipose tissue–liver cross-talk as an early event in the development of HFD-induced hepatic insulin resistance. In particular, reducing white adipose tissue (WAT) inflammation by adipocyte-specific depletion of Fas/CD95 protected mice from developing hepatic insulin resistance but not hepatic steatosis. Herein, we expanded o...
6 CitationsSource
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Rouven Mueller (UZH: University of Zurich)H-Index: 1
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 12 authors...
Low-grade inflammation in adipose tissue and liver has been implicated in obesity-associated insulin resistance and type 2 diabetes. Yet, the contribution of inflammatory cells to the pathogenesis of skeletal muscle insulin resistance remains elusive. In a large cohort of obese human individuals, blood monocyte Fas (CD95) expression correlated with systemic and skeletal muscle insulin resistance. To test a causal role for myeloid cell Fas expression in the development of skeletal muscle insulin ...
11 CitationsSource
#1Nurit Hadad (BGU: Ben-Gurion University of the Negev)H-Index: 15
#2Olga Burgazliev (BGU: Ben-Gurion University of the Negev)H-Index: 1
Last.Rachel Levy (BGU: Ben-Gurion University of the Negev)H-Index: 36
view all 9 authors...
In established obesity, inflammation and macrophage recruitment likely contribute to the development of insulin resistance. In the current study, we set out to explore whether adipose tissue infiltration by neutrophils that occurs early (3 days) after initiating a high-fat diet (HFD) could contribute to the early occurrence of hepatic insulin resistance and to determine the role of cytosolic phospholipase A2α (cPLA2α) in this process. The 3-day HFD caused a significant upregulation of cPLA2α in ...
30 CitationsSource
#1Michael S. F. Wiedemann (UZH: University of Zurich)H-Index: 3
#2Stephan Wueest (Boston Children's Hospital)H-Index: 15
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 5 authors...
High-fat feeding for 3-4 days impairs glucose tolerance and hepatic insulin sensitivity. However, it remains unclear whether the evolving hepatic insulin resistance is due to acute lipid overload or the result of induced adipose tissue inflammation and consequent dysfunctional adipose tissue-liver cross-talk. In the present study, feeding C57Bl6/J mice a fat-enriched diet [high-fat diet (HFD)] for 4 days induced glucose intolerance, hepatic insulin resistance (as assessed by hyperinsulinemic eug...
42 CitationsSource
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