Je-Yoel Cho
Kyungpook National University
Molecular biologyOsteoblastCancer researchTranscription factorBiology
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Publications 62
#1Ji-Hyun Lee (SNU: Seoul National University)H-Index: 9
#2Dong-Seol Lee (SNU: Seoul National University)H-Index: 13
Last. Joo-Cheol Park (SNU: Seoul National University)H-Index: 23
view all 8 authors...
Abstract The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on the odontogenic differentiation of human dental pulp stem cells (hDPSCs) in vitro and in vivo . Furthermore, we analyzed the PA-CM by liquid chromatography-mass spectrometry...
51 CitationsSource
#1You La Lee (KNU: Kyungpook National University)H-Index: 6
#2Byeong-Cheol Ahn (KNU: Kyungpook National University)H-Index: 21
Last. Jaetae Lee (KNU: Kyungpook National University)H-Index: 19
view all 6 authors...
Hepatocellular carcinoma is a common malignancy. The carcinoma cells express glypican-3 (GPC-3) on the cell membrane. GPC-3 is also expressed in melanoma cells. Therefore, GPC-3 might be a potential target for tumor imaging or therapy. Here, proteomic mass spectrometry was used to identify peptides that target GPC-3-expressing tumors. A mammalian expression vector expressing a FLAG-GPC-3 fusion protein was cloned for immunoprecipitation. With the use of liposomes, the vector was transfected into...
19 CitationsSource
#1Arul Narayanasamy (KNU: Kyungpook National University)H-Index: 1
#2Jung-Mo Ahn (KNU: Kyungpook National University)H-Index: 9
Last. Je-Yoel Cho (KNU: Kyungpook National University)H-Index: 29
view all 7 authors...
Abstract Human lung cancer is a major cause of cancer mortality worldwide. Understanding the pathophysiological features and the development of novel biomarkers for diagnosis as well as treatment are major tasks. In the present study, sera from ten SQLC patients and healthy control (HEC) were collected and pooled, respectively. The pooled sera were depleted via an immunoaffinity method and further subjected to fucosylation enrichment. Enriched fucosylated glycoproteins were resolved by SDS-PAGE ...
32 CitationsSource
#1Sun-Hee Heo (KNU: Kyungpook National University)H-Index: 8
#2Young-Jin Choi (KNU: Kyungpook National University)H-Index: 3
Last. Je-Yoel Cho (KNU: Kyungpook National University)H-Index: 29
view all 5 authors...
Periodontitis is an inflammatory disease, which, when severe, can result in tooth loss, that affects the quality of life. S100A2 was previously identified as a component of gingival crevicular fluid (GCF) via proteome analysis, but it has not been investigated whether S100A2 plays a role in periodontitis. In this study, we analyzed mRNA expression of S100A2 in gingival tissues from normal and classified periodontal disease patients and compared it to that of S100A8 and S100A9. Quantitative real ...
11 CitationsSource
#1Geum-Hwa Lee (CBNU: Chonbuk National University)H-Index: 17
#2Jung-Doo Hwang (CBNU: Chonbuk National University)H-Index: 1
Last. Hyung-ryongKIM (Wonkwang University)H-Index: 33
view all 8 authors...
Abstract BAX Inhibitor-1 (BI-1), a transmembrane protein on the endoplasmic reticulum, has been studied previously in various physio/pathological conditions, but not in bone cells. In this study, using the MG63 osteoblast cell line and osteoblasts differentiated from stem cells, the role of BI-1 was studied. First, expression of BI-1 was confirmed in osteoblasts, as well as osteoclasts, in mouse tibiae bone immunohistochemistry. For evaluation of a recently published property of BI-1, an acidic ...
18 CitationsSource
#1Joung-Hwan Oh (SNU: Seoul National University)H-Index: 7
#2Jihye Seo (SNU: Seoul National University)H-Index: 3
Last. Kyung Mi Woo (SNU: Seoul National University)H-Index: 26
view all 7 authors...
The fibre structure of engineered matrix that mimic the morphology of type I collagen has exhibited good biological performance for bone regeneration. However, the mechanism by which synthetic fibres promote osteoblast differentiation has yet to be determined. In this study, we demonstrate that fibre structure of an engineered matrix suppresses the degradation of Runx2, a master transcription factor that can turn on to osteoblast differentiation. MC3T3-E1 pre-osteoblasts grown on a fibrous colla...
5 CitationsSource
#1Byung-Gyu Kim (KNU: Kyungpook National University)H-Index: 10
#2Youn-Je ParkH-Index: 1
Last. Je-Yoel Cho (KNU: Kyungpook National University)H-Index: 29
view all 4 authors...
Continuous treatment with parathyroid hormone (PTH) or excess endogenous PTH due to primary hyperparathyroidism causes increased bone resorption and, subsequently, decreased bone volume. Our previous studies showed that myeloid Elf-1-like factor (MEF) not only suppresses osteoblast differentiation through inhibition of Runx2 activity and other osteogenesis-related genes but also specifically increases the expression of Mab21, a potential transcriptional repressor of osteoblast differentiation. H...
4 CitationsSource
#1Ji-Hyun LeeH-Index: 4
#2Young Jin ChoiH-Index: 20
Last. Je-Yoel Cho (KNU: Kyungpook National University)H-Index: 29
view all 5 authors...
Periodontitis is a very prevalent disease. Therefore, biomarkers for the early and standard diagnoses of periodontitis are urgently needed. TACE is a membrane-bound metalloprotease. Although a recent study suggested that TACE levels in GCF are elevated during periodontal disease, the levels of TACE in GCF at different stages of chronic periodontitis have not been determined. Here, we analyzed the protein levels of TACE in GCF from periodontal disease subjects and confirmed that the protein level...
8 CitationsSource
#1Young-Jin Choi (KNU: Kyungpook National University)H-Index: 3
#2Sun-Hee Heo (KNU: Kyungpook National University)H-Index: 8
Last. Je-Yoel Cho (KNU: Kyungpook National University)H-Index: 29
view all 4 authors...
Background The inflammatory disease periodontitis results in tooth loss and can even lead to diseases of the whole body if not treated. Gingival crevicular fluid (GCF) reflects the condition of the gingiva and contains proteins transuded from serum or cells at inflamed sites. In this study, we aimed to discover potential protein biomarkers for periodontitis in GCF proteome using LC-MS/MS.
30 CitationsSource
#1Eun-Hyang Lee (KNU: Kyungpook National University)H-Index: 3
#2Hye-Jeong Park (KNU: Kyungpook National University)H-Index: 7
Last. Je-Yoel Cho (KNU: Kyungpook National University)H-Index: 29
view all 8 authors...
Human adult dental pulp stem cells (hDPSCs) are a unique precursor population isolated from postnatal dental pulp and have the ability to regenerate a reparative dentin-like complex. In this study, we investigated the role of Asporin in hDPSCs, which was identified as a matrix protein in our previous dentin proteomic analysis. We isolated a clonogenic, highly proliferative population of cells from adult human dental pulp. These isolated hDPSCs were confirmed by fluorescence activated cell sortin...
12 CitationsSource