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Seok Ju Park
Inje University
28Publications
6H-index
100Citations
Publications 28
Newest
#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Shraddha Parate (Gyeongsang National University)H-Index: 1
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 9 authors...
Abstract Breast cancer is one of the major impediments affecting women globally. The ATP-dependant heat shock protein 90 (Hsp90) forms the central component of molecular chaperone machinery that predominantly governs the folding of newly synthesized peptides and their conformational maturation. It regulates the stability and function of numerous client proteins that are frequently upregulated and/or mutated in cancer cells, therefore, making Hsp90 inhibition a promising therapeutic strategy for ...
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#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Ayoung Baek (Gyeongsang National University)H-Index: 7
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 11 authors...
Aromatase inhibitors with an \mathrm{IC}_{50}IC 50 value ranging from 1.4 to 49.7 µM are known to act as antiepileptic drugs besides being potential breast cancer inhibitors. The aim of the present study is to identify novel antiepileptic aromatase inhibitors with higher activity exploiting the ligand-based pharmacophore approach utilizing the experimentally known inhibitors. The resultant Hypo1 consists of four features and was further validated by using three different strategies. Hypo1 was...
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#1Dong Hoon Choi (Inje University)
#2Jee Eun Hong (Inje University)H-Index: 1
Last.Yo-Han Park (Inje University)H-Index: 13
view all 10 authors...
In this study, gold nanoparticles were supported at graphene derivatives (AuNPs@GDs) from chloroauric acid and graphene oxide (GO) by using sodium citrate, L-ascorbic acid, and 4-(2-hydroxyethyl)-1-piperazineethane-sulfonic acid (HEPES) as green reductants to evaluate the catalytic activity in the 4-nitrophenol (4-NP) reduction system. Among the three reductants, HEPES which derived AuNP@GD (3) exhibited up to 8.44-fold higher catalytic activity compared with sodium citrate and L-ascorbic acid. ...
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#1Shailima Rampogu (Gyeongsang National University)H-Index: 7
#2Chanin Park (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 14 authors...
Breast cancer (BC) is the leading cause of death among women worldwide devoid of effective treatment. It is therefore important to develop agents that can reverse, reduce, or slow the growth of BC. The use of natural products as chemopreventive agents provides enormous advantages. The aim of the current investigation is to determine the efficacy of the phytochemicals against BC along with the approved drugs to screen the most desirable and effective phytocompound. In the current study, 36 phytoc...
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#1Shailima RampoguH-Index: 7
#2Ayoung BaekH-Index: 7
Last.Keun Woo LeeH-Index: 30
view all 11 authors...
Angiogenesis is defined as the formation of new blood vessels and is a key phenomenon manifested in a host of cancers during which tyrosine kinases play a crucial role. Vascular endothelial growth factor receptor-2 (VEGFR-2) is pivotal in cancer angiogenesis, which warrants the urgency of discovering new anti-angiogenic inhibitors that target the signalling pathways. To obtain this objective, a structure-based pharmacophore model was built from the drug target VEGFR-2 (PDB code: 4AG8), complexed...
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#1Rabia Mukhtar RanaH-Index: 1
#2Shailima RampoguH-Index: 7
Last.Keun Woo LeeH-Index: 30
view all 11 authors...
Dihydrofolate reductase (DHFR) is an essential cellular enzyme and thereby catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). In cancer medication, inhibition of human DHFR (hDHFR) remains a promising strategy, as it depletes THF and slows DNA synthesis and cell proliferation. In the current study, ligand-based pharmacophore modeling identified and evaluated the critical chemical features of hDHFR inhibitors. A pharmacophore model (Hypo1) was generated from known inhibitors of D...
1 CitationsSource
#1Amir Zeb (Gyeongsang National University)H-Index: 5
#2Minky Son (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 6 authors...
Abstract Deregulation of Cdk5 is a hallmark in neurodegenerative diseases and its complex with p25 forms Cdk5/p25, thereby causes severe neuropathological insults. Cdk5/p25 abnormally phosphorylates tau protein, and induces tau-associated neurofibrillary tangles in neurological disorders. Therefore, the pharmacological inhibition of Cdk5/p25 alleviates tau-associated neurological disorders. Herein, computational simulations probed two candidate inhibitors of Cdk5/p25. Structure-based pharmacopho...
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#1Amir Zeb (Gyeongsang National University)H-Index: 5
#2Chanin Park (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 7 authors...
Proteins deacetylation by Histone deacetylase 6 (HDAC6) has been shown in various human chronic diseases like neurodegenerative diseases and cancer, and hence is an important therapeutic target. Since, the existing inhibitors have hydroxamate group, and are not HDAC6-selective, therefore, this study has designed to investigate non-hydroxamate HDAC6 inhibitors. Ligand-based pharmacophore was generated from 26 training set compounds of HDAC6 inhibitors. The statistical parameters of pharmacophore ...
1 CitationsSource
#1Amir Zeb (Gyeongsang National University)H-Index: 5
#2Chanin Park (Gyeongsang National University)H-Index: 8
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 11 authors...
Abstract Photodynamic therapy (PDT) is a rapidly evolving area of cancer management against solid tumors. PDT is either administrated by injecting photosensitizer (porphyrins) or by accumulation of intracellular protoporphyrin IX via the inhibition of human Protoporphyrinogen Oxidase IX (hPPO). In this study, novel inhibitors of hPPO have been investigated by integrating virtual screening, molecular docking, and molecular dynamics (MD) simulation. A ligand-based pharmacophore was generated from ...
1 CitationsSource
#1Rohit Bavi (Gyeongsang National University)H-Index: 4
#2Raj Kumar (Gyeongsang National University)H-Index: 5
Last.Keun Woo Lee (Gyeongsang National University)H-Index: 30
view all 7 authors...
AbstractHigh level of hematopoietic cell kinase (Hck) is associated with drug resistance in chronic myeloid leukemia. Additionally, Hck activity has also been connected with the pathogenesis of HIV-1 and chronic obstructive pulmonary disease. In this study, three-dimensional (3D) QSAR pharmacophore models were generated for Hck based on experimentally known inhibitors. A best pharmacophore model, Hypo1, was developed with high correlation coefficient (0.975), Low RMS deviation (0.60) and large c...
4 CitationsSource
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