Michael D. Gunn
Duke University
ChemokineImmunologyMedicineBiologyImmune system
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Publications 100
Efficacy of dendritic cell (DC) cancer vaccines is classically thought to depend on their antigen-presenting cell (APC) activity. Studies show, however, that DC vaccine priming of cytotoxic T lymphocytes (CTLs) requires the activity of endogenous DCs, suggesting that exogenous DCs stimulate antitumor immunity by transferring antigens (Ags) to endogenous DCs. Such Ag transfer functions are most commonly ascribed to monocytes, implying that undifferentiated monocytes would function equally well as...
6 CitationsSource
#1Yen-Rei A. Yu (Duke University)H-Index: 10
#2Yuryi Malakhau (Duke University)H-Index: 1
Last. Michael D. Gunn (Duke University)H-Index: 42
view all 10 authors...
An increasing body of evidence suggests that bone marrow-derived myeloid cells play a critical role in the pathophysiology of pulmonary hypertension (PH). However, the true requirement for myeloid cells in PH development has not been demonstrated, and a specific disease-promoting myeloid cell population has not been identified. Using bone marrow chimeras, lineage labeling, and proliferation studies, we determined that, in murine hypoxia-induced PH, Ly6C(lo) nonclassical monocytes are recruited t...
1 CitationsSource
#1John H. Sampson (Duke University)H-Index: 74
#2Michael D. Gunn (Duke University)H-Index: 42
Last. David M. Ashley (Duke University)H-Index: 42
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Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet, seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of the immune system within the central nervous system (CNS) and altered the paradigm for successful immunotherapy. The impact of standard therapies on the response to immunotherapy is now better understood, as well. This new knowledge has implications for a broad range of tumours that develop within the CNS. Neverthel...
8 CitationsSource
#1Xiaohan Lu (Duke University)H-Index: 4
#2Nathan P. Rudemiller (Duke University)H-Index: 14
Last. Steven D. Crowley (Duke University)H-Index: 27
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Dendritic cells (DCs) promote hypertension via the activation of T cells, but the specific DC subtypes that mediate hypertension require elucidation. We previously found that Fms-like tyrosine kina...
BACKGROUND: Following an acute insult, macrophages regulate renal fibrogenesis through the release of various factors that either encourage the synthesis of extracellular matrix synthesis or the degradation of matrix via endocytosis, proteolysis, or both. However, the roles of infiltrating versus resident myeloid cells in these opposing processes require elucidation. The transcription factor Twist1 controls diverse essential cellular functions through induction of several downstream targets, inc...
1 CitationsSource
#1Vidyalakshmi Chandramohan (Duke University)H-Index: 10
#2Xuhui Bao (Duke University)H-Index: 6
Last. Darell D. Bigner (Duke University)H-Index: 117
view all 13 authors...
D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma. In addition to inherent tumoricidal activity, immunotoxins induce secondary immune responses through the activation of T cells. However, glioblastoma-induced immune suppression is a major obstacle to an effective and durable immunotoxin-mediated antitumor response. We hypothesized that D2C7-IT-induced immune response could be effective...
4 CitationsSource
#1Yen-Rei A. Yu (Duke University)H-Index: 10
#2J.M. Daly (Duke University)
Last. Robert M. Tighe (Duke University)H-Index: 11
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#1Satyanarayana Achanta (Duke University)H-Index: 9
#2Boyi Liu (Duke University)H-Index: 15
Last. Sven-Eric Jordt (Duke University)H-Index: 29
view all 10 authors...
#2Michael D. GunnH-Index: 42
Last. Sallie R. PermarH-Index: 29
view all 11 authors...
#1Pakawat Chongsathidkiet (Duke University)H-Index: 9
#2Christina Jackson (Johns Hopkins University)H-Index: 8
Last. Peter E. Fecci (Duke University)H-Index: 24
view all 23 authors...
In the version of this article originally published, the figure callout in this sentence was incorrect: “Furthermore, in S1P1-KI mice themselves, whereas PD-1 blockade was ineffectual as monotherapy, the effects of 4-1BB agonism and checkpoint blockade proved additive, with the combination prolonging median survival and producing a 50% long-term survival rate (Fig. 6f).” The callout should have been to Supplementary Fig. 6b. The error has been corrected in the PDF and HTML versions of the articl...
1 CitationsSource