Michael D. Gunn
Duke University
Publications 98
Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet, seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of the immune system within the central nervous system (CNS) and altered the paradigm for successful immunotherapy. The impact of standard therapies on the response to immunotherapy is now better understood, as well. This new knowledge has implications for a broad range of tumours that develop within the CNS. Neverthel...
1 CitationsSource
#1Vidyalakshmi Chandramohan (Duke University)H-Index: 11
#2Xuhui Bao (Duke University)H-Index: 5
Last.Darell D. Bigner (Duke University)H-Index: 116
view all 13 authors...
D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma. In addition to inherent tumoricidal activity, immunotoxins induce secondary immune responses through the activation of T cells. However, glioblastoma-induced immune suppression is a major obstacle to an effective and durable immunotoxin-mediated antitumor response. We hypothesized that D2C7-IT-induced immune response could be effective...
#1Xiaohan Lu (Duke University)H-Index: 2
#2Nathan P. Rudemiller (Duke University)H-Index: 12
Last.Steven D. Crowley (Duke University)H-Index: 25
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#1Yen-Rei A. Yu (Duke University)H-Index: 9
#2J. Daly (Duke University)
Last.Robert M. Tighe (Duke University)H-Index: 9
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#1Satyanarayana Achanta (Duke University)H-Index: 8
#2Boyi Liu (Duke University)H-Index: 17
Last.Sven-Eric Jordt (Duke University)H-Index: 28
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#2Michael D. GunnH-Index: 42
Last.Sallie R. PermarH-Index: 27
view all 11 authors...
#1Pakawat Chongsathidkiet (Duke University)H-Index: 8
#2Christina Jackson (Johns Hopkins University)H-Index: 5
Last.Peter E. Fecci (Duke University)H-Index: 21
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In the version of this article originally published, the figure callout in this sentence was incorrect: “Furthermore, in S1P1-KI mice themselves, whereas PD-1 blockade was ineffectual as monotherapy, the effects of 4-1BB agonism and checkpoint blockade proved additive, with the combination prolonging median survival and producing a 50% long-term survival rate (Fig. 6f).” The callout should have been to Supplementary Fig. 6b. The error has been corrected in the PDF and HTML versions of the articl...
#1Phillip D. RiveraH-Index: 9
#2Richa Hanamsagar (Center for Autism and Related Disorders)H-Index: 7
Last.Staci D. Bilbo (Center for Autism and Related Disorders)H-Index: 40
view all 8 authors...
Abstract Drugs of abuse promote a potent immune response in central nervous system (CNS) via the activation of microglia and astrocytes. However, the molecular mechanisms underlying microglial activation during addiction are not well known. We developed and functionally characterized a novel transgenic mouse (Cx3cr1-CreBTtg/0:MyD88f/f [Cretg/0]) wherein the immune signaling adaptor gene, MyD88, was specifically deleted in microglia. To test the downstream effects of loss of microglia-specific My...
3 CitationsSource