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Ah Ram Lee
Konkuk University
10Publications
4H-index
40Citations
Publications 10
Newest
Published on Jun 1, 2019in Journal of Hepatology18.95
Eun-Sook Park10
Estimated H-index: 10
(Konkuk University),
Ah Ram Lee4
Estimated H-index: 4
(Konkuk University)
+ 23 AuthorsHong Seok Kang6
Estimated H-index: 6
(Konkuk University)
Background & Aims Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Methods Two patients with viral breakthrough during treatment with TDF-containing regimens were prospectively enrolled. The gene encoding HBV reverse transcriptase was sequenced. ...
Published on May 15, 2019in The EMBO Journal11.23
Eun-Sook Park10
Estimated H-index: 10
(Konkuk University),
Young-Ho Byun12
Estimated H-index: 12
(Yonsei University)
+ 22 AuthorsGu-Choul Shin5
Estimated H-index: 5
(Konkuk University)
Abstract The multifunctional influenza virus protein PB1‐F2 plays several roles in deregulation of host innate immune responses and is a known immunopathology enhancer of the 1918 influenza pandemic. Here, we show that the 1918 PB1‐F2 protein not only interferes with the mitochondria‐dependent pathway of type I interferon (IFN) signaling, but also acquired a novel IFN antagonist function by targeting the DEAD‐box helicase DDX3, a key downstream mediator in antiviral interferon signaling, toward ...
Published on Dec 1, 2018in Nature Communications11.88
Doo Hyun Kim6
Estimated H-index: 6
(Konkuk University),
Eun-Sook Park10
Estimated H-index: 10
(Konkuk University)
+ 14 AuthorsByeong June Jae1
Estimated H-index: 1
(Konkuk University)
Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription an...
Published on Jun 6, 2018in Journal of Virology4.32
Ah Ram Lee4
Estimated H-index: 4
(Konkuk University),
Keo Heun Lim1
Estimated H-index: 1
(Konkuk University)
+ 12 AuthorsJuhee Won1
Estimated H-index: 1
(Konkuk University)
Published on May 15, 2018in Gut and Liver2.97
Doo Hyun Kim6
Estimated H-index: 6
,
Hong Seok Kang6
Estimated H-index: 6
+ 9 AuthorsSo Young Kwon16
Estimated H-index: 16
(Konkuk University)
Published on Jan 1, 2018in Gut17.94
Keo Heun Lim1
Estimated H-index: 1
(Konkuk University),
Eun-Sook Park10
Estimated H-index: 10
(Konkuk University)
+ 20 AuthorsChang Wook Kim1
Estimated H-index: 1
(Catholic University of Korea)
Objective Interferons (IFNs) mediate direct antiviral activity. They play a crucial role in the early host immune response against viral infections. However, IFN therapy for HBV infection is less effective than for other viral infections. Design We explored the cellular targets of HBV in response to IFNs using proteome-wide screening. Results Using LC-MS/MS, we identified proteins downregulated and upregulated by IFN treatment in HBV X protein (HBx)-stable and control cells. We found several IFN...
Published on Dec 1, 2016in Autophagy11.06
Gu-Choul Shin5
Estimated H-index: 5
(Konkuk University),
Hong Seok Kang6
Estimated H-index: 6
(Konkuk University)
+ 1 AuthorsKyun-Hwan Kim21
Estimated H-index: 21
(Konkuk University)
ABSTRACTDeath receptors of TNFSF10/TRAIL (tumor necrosis factor superfamily member 10) contribute to immune surveillance against virus-infected or transformed cells by promoting apoptosis. Many viruses evade antiviral immunity by modulating TNFSF10 receptor signaling, leading to persistent infection. Here, we report that hepatitis B virus (HBV) X protein (HBx) restricts TNFSF10 receptor signaling via macroautophagy/autophagy-mediated degradation of TNFRSF10B/DR5, a TNFSF10 death receptor, and th...
Published on Feb 1, 2016in Journal of Hepatology18.95
Yong Kwang Park9
Estimated H-index: 9
(Konkuk University),
Eun-Sook Park10
Estimated H-index: 10
(Konkuk University)
+ 13 AuthorsJong Man Kim15
Estimated H-index: 15
(SMC: Samsung Medical Center)
Background & Aims Cytokines are key molecules implicated in the defense against virus infection. Tumor necrosis factor-alpha (TNF-α) is well known to block the replication of hepatitis B virus (HBV). However, the molecular mechanism and the downstream effector molecules remain largely unknown. Methods In this study, we investigated the antiviral effect and mechanism of p22-FLIP (FLICE-inhibitory protein) by ectopic expression in vitro and in vivo . In addition, to provide the biological relevanc...
Published on Aug 31, 2015in PLOS ONE2.78
Doo Hyun Kim6
Estimated H-index: 6
(Konkuk University),
Ah Ram Lee4
Estimated H-index: 4
(Konkuk University)
+ 11 AuthorsKyun-Hwan Kim21
Estimated H-index: 21
(Konkuk University)
The emergence of compensatory mutations in the polymerase gene of drug resistant hepatitis B virus (HBV) is associated with treatment failure. We previously identified a multi-drug resistant HBV mutant, which displayed resistance towards lamivudine (LMV), clevudine (CLV), and entecavir (ETV), along with a strong replication capacity. The aim of this study was to identify the previously unknown compensatory mutations, and to determine the clinical relevance of this mutation during antiviral thera...
Published on Apr 1, 2015in Journal of Hepatology18.95
Doo Hyun Kim6
Estimated H-index: 6
(Konkuk University),
Beom Kyung Kim25
Estimated H-index: 25
(Yonsei University)
+ 5 AuthorsKyun-Hwan Kim21
Estimated H-index: 21
(Konkuk University)
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