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Ah Ram Lee
Konkuk University
11Publications
5H-index
80Citations
Publications 13
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Hepatitis B virus (HBV) infection is a major factor in the development of various liver diseases such as hepatocellular carcinoma (HCC). Among HBV encoded proteins, HBV X protein (HBx) is known to play a key role in the development of HCC. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear transcription factor which is critical for hepatocyte differentiation. However, the expression level as well as its regulatory mechanism in HBV infection have yet to be clarified. Here, we observed the suppress...
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#1Eun Sook Park (Konkuk University)H-Index: 11
#2Ah Ram Lee (Konkuk University)H-Index: 5
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 26 authors...
Background & Aims Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Methods Two patients with viral breakthrough during treatment with TDF-containing regimens were prospectively enrolled. The gene encoding HBV reverse transcriptase was sequenced. ...
5 CitationsSource
#1Eun Sook Park (Konkuk University)H-Index: 11
#2Young-Ho Byun (Yonsei University)H-Index: 12
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 25 authors...
3 CitationsSource
#1Doo Hyun Kim (Konkuk University)H-Index: 7
#2Eun Sook Park (Konkuk University)H-Index: 11
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 17 authors...
Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription an...
3 CitationsSource
#1Ah Ram Lee (Konkuk University)H-Index: 5
#2Keo Heun Lim (Konkuk University)H-Index: 1
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 15 authors...
1 CitationsSource
#1Doo Hyun KimH-Index: 7
#2Hong Seok KangH-Index: 5
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 12 authors...
1 CitationsSource
#1Keo Heun Lim (Konkuk University)H-Index: 1
#2Eun Sook Park (Konkuk University)H-Index: 11
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 23 authors...
Objective Interferons (IFNs) mediate direct antiviral activity. They play a crucial role in the early host immune response against viral infections. However, IFN therapy for HBV infection is less effective than for other viral infections. Design We explored the cellular targets of HBV in response to IFNs using proteome-wide screening. Results Using LC-MS/MS, we identified proteins downregulated and upregulated by IFN treatment in HBV X protein (HBx)-stable and control cells. We found several IFN...
18 CitationsSource
#1Gu Choul Shin (Konkuk University)H-Index: 11
#2Hong Seok Kang (Konkuk University)H-Index: 5
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 4 authors...
ABSTRACTDeath receptors of TNFSF10/TRAIL (tumor necrosis factor superfamily member 10) contribute to immune surveillance against virus-infected or transformed cells by promoting apoptosis. Many viruses evade antiviral immunity by modulating TNFSF10 receptor signaling, leading to persistent infection. Here, we report that hepatitis B virus (HBV) X protein (HBx) restricts TNFSF10 receptor signaling via macroautophagy/autophagy-mediated degradation of TNFRSF10B/DR5, a TNFSF10 death receptor, and th...
15 CitationsSource
#1Yong Kwang Park (Konkuk University)H-Index: 9
#2Eun Sook Park (Konkuk University)H-Index: 11
Last.Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 16 authors...
Background & Aims Cytokines are key molecules implicated in the defense against virus infection. Tumor necrosis factor-alpha (TNF-α) is well known to block the replication of hepatitis B virus (HBV). However, the molecular mechanism and the downstream effector molecules remain largely unknown. Methods In this study, we investigated the antiviral effect and mechanism of p22-FLIP (FLICE-inhibitory protein) by ectopic expression in vitro and in vivo . In addition, to provide the biological relevanc...
12 CitationsSource
12