Mirjam Bloemendaal
Radboud University Nijmegen
PsychologyNeuroscienceReactive inhibitionProactive InhibitionDopamine
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Publications 12
#1Daphne Everaerd (Radboud University Nijmegen)H-Index: 7
#2Marloes J. A. G. Henckens (Radboud University Nijmegen)H-Index: 15
Last. Izabela Przezdzik (Radboud University Nijmegen)
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Abstract Stressors induce physiological changes in the brain and periphery that support adaptive defensive responses. The consequences of psychological stress on cognitive functioning are often measured in laboratory settings using experimentally induced stress that leads to mainly negative subjective feelings. There is a need for verification of these studies using real-life stressors that may potentially induce both positive and negative subjective feelings. In an observational study, we inves...
#1Monja I. Froböse (HHU: University of Düsseldorf)H-Index: 5
#2Andrew Westbrook (Brown University)H-Index: 8
Last. Roshan Cools (Radboud University Nijmegen)H-Index: 51
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Catecholamines have long been associated with cognitive control and value-based decision-making. More recently, we have shown that catecholamines also modulate value-based decision-making about whether or not to engage in cognitive control. Yet it is unclear whether catecholamines influence these decisions by altering the subjective value of control. Thus, we tested whether tyrosine, a catecholamine precursor altered the subjective value of performing a demanding working memory task among health...
2 CitationsSource
#1Sarita A. Dam (Radboud University Nijmegen)
#2Jeanette C. Mostert (Radboud University Nijmegen)H-Index: 9
Last. Alejandro Arias-Vasquez (Radboud University Nijmegen)H-Index: 24
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#1Mirjam Bloemendaal (Radboud University Nijmegen)H-Index: 6
#2Monja I. Froböse (Radboud University Nijmegen)H-Index: 5
Last. Esther Aarts (Radboud University Nijmegen)H-Index: 22
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Abstract The aging brain is characterized by altered dopamine signaling. The amino acid tyrosine, a catecholamine precursor, is known to improve cognitive performance in young adults, especially during high environmental demands. Tyrosine administration might also affect catecholamine transmission in the aging brain, thereby improving cognitive functioning. In healthy older adults, impairments have been demonstrated in two forms of response inhibition: reactive inhibition (outright stopping) and...
1 CitationsSource
#1Ondine van de RestH-Index: 17
#2Mirjam BloemendaalH-Index: 6
Last. Esther AartsH-Index: 22
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The effects of tyrosine on plasma response and cognition in aging are unknown. We assessed the dose-dependent response to tyrosine administration in older adults in both plasma tyrosine concentrations and working memory performance. In this double blind randomized cross-over trial 17 older adults (aged 60–75 years) received a single administration of 100, 150, or 200 mg/kg body weight of tyrosine. For comparison, 17 young adults (aged 18–35 years) received a dose of 150 mg/kg body weight of tyro...
2 CitationsSource
#1Mirjam BloemendaalH-Index: 6
#1Mirjam Bloemendaal (Radboud University Nijmegen)H-Index: 6
#2Bram B. Zandbelt (Radboud University Nijmegen)H-Index: 19
Last. Esther Aarts (Radboud University Nijmegen)H-Index: 22
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Abstract Two distinct forms of response inhibition may underlie observed deficits in response inhibition in aging. We assessed whether age-related neurocognitive impairments in response inhibition reflect deficient reactive inhibition (outright stopping) or also deficient proactive inhibition (anticipatory response slowing), which might be particularly evident with high information load. We used functional magnetic resonance imaging in young (n = 25, age range 18–32) and older adults (n = 23, 61...
9 CitationsSource
#1Mirjam BloemendaalH-Index: 6
#2Martine R. van Schouwenburg (UC: University of California)H-Index: 9
Last. Roshan CoolsH-Index: 51
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Dopamine has long been implicated in the online maintenance of information across short delays. Specifically, dopamine has been proposed to modulate the strength of working memory representations in the face of intervening distracters. This hypothesis has not been tested in humans. We fill this gap using pharmacological neuroimaging. Healthy young subjects were scanned after intake of the dopamine receptor agonist bromocriptine or placebo (in a within-subject, counterbalanced, and double-blind d...
23 CitationsSource
#1Antoin D. de Weijer (UU: Utrecht University)H-Index: 11
#2Iris E. Sommer (UU: Utrecht University)H-Index: 49
Last. Eduard H.J.F. BoezemanH-Index: 1
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Abstract The great majority of studies on repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool for auditory verbal hallucinations (AVH) have used 1-Hz stimulation with inconsistent results. Recently, it has been suggested that 20-Hz rTMS has strong therapeutic effects. It is conceivable that this 20-Hz stimulation is more effective than 1-Hz stimulation. The aim of this preliminary study is to investigate the efficacy of 20-Hz rTMS compared with 1-Hz rTMS as a treatment for ...
8 CitationsSource
SUMMARY: Stimulating brain areas with transcranial magnetic stimulation (TMS) while concurrently and noninvasively recording brain activity changes through functional MRI enables a new range of investigations about causal interregional interactions in the human brain. However, standard head-coil arrangements for current methods for concurrent TMS-functional MRI somewhat restrict the cortical brain regions that can be targeted with TMS because space in typical MR head coils is limited. Another li...
8 CitationsSource