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Hongyu Gao
Washington University in St. Louis
9Publications
9H-index
5,528Citations
Publications 9
Newest
Published on Sep 1, 2015in Medicine 1.87
Marcela Rodriguez7
Estimated H-index: 7
,
Patrick G. Hogan10
Estimated H-index: 10
+ 7 AuthorsStephanie A. Fritz14
Estimated H-index: 14
Historically, a number of typing methods have been evaluated for Staphylococcus aureus strain characterization. The emergence of contemporary strains of community-associated S. aureus, and the ensuing epidemic with a predominant strain type (USA300), necessitates re-evaluation of the discriminatory power of these typing methods for discerning molecular epidemiology and transmission dynamics, essential to investigations of hospital and community outbreaks. We compared the discriminatory index of ...
Published on Dec 1, 2013in Journal of Clinical Microbiology 4.96
George Turabelidze1
Estimated H-index: 1
,
Steven J. Lawrence11
Estimated H-index: 11
(WashU: Washington University in St. Louis)
+ 8 AuthorsRomesh Gautom7
Estimated H-index: 7
The current pathogen-typing methods have suboptimal sensitivities and specificities. DNA sequencing offers an opportunity to type pathogens with greater degrees of discrimination using single nucleotide polymorphisms (SNPs) than with pulsed-field gel electrophoresis (PFGE) and other methodologies. In a recent cluster of Escherichia coli O157:H7 infections attributed to salad bar exposures and romaine lettuce, a subset of cases denied exposure to either source, although PFGE and multiple-locus va...
Published on Jan 1, 2013in Antimicrobial Agents and Chemotherapy 4.71
Truc T. Tran17
Estimated H-index: 17
,
Diana Panesso24
Estimated H-index: 24
(El Bosque University)
+ 11 AuthorsNagendra N. Mishra24
Estimated H-index: 24
(UCLA: University of California, Los Angeles)
Development of daptomycin (DAP) resistance in Enterococcus faecalis has recently been associated with mutations in genes encoding proteins with two main functions: (i) control of the cell envelope stress response to antibiotics and antimicrobial peptides (LiaFSR system) and (ii) cell membrane phospholipid metabolism (glycerophosphoryl diester phosphodiesterase and cardiolipin synthase [cls]). However, the genetic bases for DAP resistance in Enterococcus faecium are unclear. We performed whole-ge...
Published on Jan 1, 2013in Genome Biology 14.03
Yanhua Zhou32
Estimated H-index: 32
(WashU: Washington University in St. Louis),
Hongyu Gao9
Estimated H-index: 9
(WashU: Washington University in St. Louis)
+ 13 AuthorsDavid E. Nelson43
Estimated H-index: 43
(IU: Indiana University Bloomington)
Background Characterizing the biogeography of the microbiome of healthy humans is essential for understanding microbial associated diseases. Previous studies mainly focused on a single body habitat from a limited set of subjects. Here, we analyzed one of the largest microbiome datasets to date and generated a biogeographical map that annotates the biodiversity, spatial relationships, and temporal stability of 22 habitats from 279 healthy humans.
Published on Jun 14, 2012in Nature 43.07
Barbara A. Methé5
Estimated H-index: 5
(JCVI: J. Craig Venter Institute),
Karen E. Nelson71
Estimated H-index: 71
(JCVI: J. Craig Venter Institute)
+ 245 AuthorsJonathan H. Badger32
Estimated H-index: 32
(JCVI: J. Craig Venter Institute)
The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.
Published on Jun 14, 2012in Nature 43.07
Curtis Huttenhower68
Estimated H-index: 68
(Broad Institute),
Dirk Gevers66
Estimated H-index: 66
(Broad Institute)
+ 245 AuthorsRobert S. Fulton80
Estimated H-index: 80
(WashU: Washington University in St. Louis)
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.
Published on Jun 13, 2012in PLOS ONE 2.78
Doyle V. Ward30
Estimated H-index: 30
(Broad Institute),
Dirk Gevers66
Estimated H-index: 66
(Broad Institute)
+ 64 AuthorsCesar Arze12
Estimated H-index: 12
(UMB: University of Maryland, Baltimore)
Published on Jun 13, 2012in PLOS ONE 2.78
Kristine M. Wylie23
Estimated H-index: 23
(WashU: Washington University in St. Louis),
Rebecca M. Truty6
Estimated H-index: 6
(UCSF: University of California, San Francisco)
+ 6 AuthorsKatherine S. Pollard50
Estimated H-index: 50
(UCSF: University of California, San Francisco)
The human gut harbors thousands of bacterial taxa. A profusion of metagenomic sequence data has been generated from human stool samples in the last few years, raising the question of whether more taxa remain to be identified. We assessed metagenomic data generated by the Human Microbiome Project Consortium to determine if novel taxa remain to be discovered in stool samples from healthy individuals. To do this, we established a rigorous bioinformatics pipeline that uses sequence data from multipl...
Published on Jun 1, 2012in PubMed Central
Eric J. Alm55
Estimated H-index: 55
,
Jonathan Friedman15
Estimated H-index: 15
,
Christopher Smillie13
Estimated H-index: 13
Published on Jan 1, 2012in Bioinformatics 4.53
Guohui Yao2
Estimated H-index: 2
(WashU: Washington University in St. Louis),
Liang Ye5
Estimated H-index: 5
(WashU: Washington University in St. Louis)
+ 3 AuthorsGeorge M. Weinstock98
Estimated H-index: 98
(WashU: Washington University in St. Louis)
Motivation: No individual assembly algorithm addresses all the known limitations of assembling short-length sequences. Overall reduced sequence contig length is the major problem that challenges the usage of these assemblies. We describe an algorithm to take advantages of different assembly algorithms or sequencing platforms to improve the quality of next-generation sequence (NGS) assemblies. Results: The algorithm is implemented as a graph accordance assembly (GAA) program. The algorithm constr...
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