Sandra T. Davidge
University of Alberta
Publications 281
#1Christy-Lynn M. Cooke (U of A: University of Alberta)H-Index: 9
#2Sandra T. Davidge (U of A: University of Alberta)H-Index: 52
Delaying pregnancy, which is on the rise, may increase the risk of cardiovascular disease in both women and their children. The physiological mechanisms that lead to these effects are not fully und...
Agents that block the renin–angiotensin system (RAS) improve glucoregulation in the metabolic syndrome disorder. We evaluated the effects of egg white hydrolysate (EWH), previously shown to modulate the protein abundance of RAS component in vivo , on glucose homeostasis in diet-induced insulin-resistant rats. Sprague–Dawley rats were fed a high-fat diet (HFD) for 6 weeks to induce insulin resistance. They were then randomly divided into four groups receiving HFD or HFD supplemented with differen...
Clinical and experimental data suggest that maternal diabetes mellitus (MDM) has transgenerational consequences with a high incidence of cardiovascular disease (CVD) observed in adult offspring. Infants of DM mothers (IDMs) are known to evolve ventricular hypertrophy and diastolic dysfunction in
#1Wang LiaoH-Index: 3
#2Hongbing FanH-Index: 1
Last.Jianping WuH-Index: 32
view all 4 authors...
SCOPE: It is found in the previous study that egg‐white‐derived antihypertensive peptide Ile‐Arg‐Trp (IRW) upregulated angiotensin converting enzyme 2 (ACE2) in spontaneously hypertensive rats (SHRs). The objective of this study is to evaluate the contribution of ACE2 activation by IRW to blood‐pressure‐lowering activity in vivo. METHODS AND RESULTS: Adult male SHRs (13–15 week old) are assigned into four groups: 1) untreated with saline infusion; 2) IRW administration (15 mg per kg body weight)...
#1Analia S. Loria (UK: University of Kentucky)H-Index: 14
Last.Sandra T. DavidgeH-Index: 2
view all 4 authors...
Abstract The developmental origins of health and disease (DOHaD) theory posits that suboptimal environments in utero and/or early postnatal life can cause structural and functional changes in key organ systems, thereby predisposing the individual to chronic disease in later life. Epidemiological, clinical, and preclinical studies show that the cardiovascular, metabolic, and neuroendocrine systems of the offspring can be influenced by environmental factors per se, or maternal responses to such st...
#1Floor Spaans (U of A: University of Alberta)H-Index: 6
#2Anita Quon (U of A: University of Alberta)H-Index: 10
Last.Sandra T. Davidge (U of A: University of Alberta)H-Index: 52
view all 9 authors...
Syncytiotrophoblast extracellular vesicles (STBEVs), released into the maternal circulation during pregnancy, have been shown to affect vascular function; however, the mechanism remains unknown. In rats, STBEVs were shown to reduce endothelium-mediated vasodilation via lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a multi-ligand scavenger receptor that has been associated with vascular dysfunction. Recently, LOX-1 was shown to interact with the angiotensin II type 1 receptor (...