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Sandra T. Davidge
University of Alberta
EndocrinologyMesenteric arteriesDiabetes mellitusMedicineBiology
275Publications
54H-index
8,549Citations
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Publications 304
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#1E. Ganguly (U of A: University of Alberta)H-Index: 1
#2Nataliia Hula (U of A: University of Alberta)
Last. Sandra T. Davidge (U of A: University of Alberta)H-Index: 54
view all 5 authors...
Abstract The Developmental Origins of Health and Disease (DOHaD) theory states that a sub-optimal prenatal and early postnatal environment during development leads to an increased risk of long-term development of adult chronic diseases. Developmental programming of disease has the potential to greatly impact the health of our population. Therefore, research has focused on the development of primary treatment strategies and/or therapeutic interventions for individuals who are at increased risk, w...
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#1Forough Jahandideh (U of A: University of Alberta)H-Index: 5
#2Stephane L. Bourque (U of A: University of Alberta)H-Index: 13
Last. Jerome Y. Yager (U of A: University of Alberta)H-Index: 26
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Stressors during the fetal and postnatal period affect the growth and developmental trajectories of offspring, causing lasting effects on physiologic regulatory systems. Here, we tested whether reduced uterine artery blood flow in late pregnancy would alter body composition in the offspring, and whether feeding offspring a western diet (WD) would aggravate these programming effects. Pregnant rats underwent bilateral uterine artery ligation (BUAL) or sham surgery on gestational day (GD)18 (term =...
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#1Floor Spaans (U of A: University of Alberta)H-Index: 6
#1Floor Spaans (U of A: University of Alberta)H-Index: 2
Last. Sandra T. Davidge (U of A: University of Alberta)H-Index: 54
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Vascular complications in pregnancy (e.g. preeclampsia) are a major source of maternal and foetal morbidity and mortality, and may be due to excessive release of placental syncytiotrophoblast-derived extracellular vesicles (STBEVs) into the maternal circulation. Increased activity of the multi-ligand scavenger receptor Lectin-like Oxidized LDL Receptor-1 (LOX-1) is associated with vascular dysfunction, and LOX-1 has been shown to interact with angiotensin II receptor type 1 (AT1). We hypothesize...
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PURPOSE: To determine the role of moderate-to-vigorous physical activity (MVPA) and sedentary behavior in flow-mediated dilation (FMD) and glucose metabolism during late pregnancy. METHODS: Seventy normotensive, euglycemic pregnant women (31.6 +/- 2.9 yr) in their third trimester (28-39 wk) were recruited. After a fasted blood sample; FMD was measured (brachial artery Doppler ultrasonography, normalized for the shear stimulus [area under the curve]). Anterograde and retrograde shear rate were es...
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#1Tina Napso (University of Cambridge)H-Index: 1
#2Yin-Po Hung (University of Cambridge)H-Index: 1
Last. Amanda N. Sferruzzi-Perri (University of Cambridge)H-Index: 25
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#1Praveen Kumar (U of A: University of Alberta)
#2Jude S. Morton (U of A: University of Alberta)H-Index: 22
Last. Lisa K. HornbergerH-Index: 25
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Aim We sought to explore whether fetal hypoxia exposure, an insult of placental insufficiency, is associated with left ventricular dysfunction and increased aortic stiffness at early postnatal ages.
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#1Tina Napso (University of Cambridge)H-Index: 1
#2Yin-Po Hung (University of Cambridge)H-Index: 1
Last. Amanda N. Sferruzzi-Perri (University of Cambridge)H-Index: 25
view all 5 authors...
Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relation to the growth of female and male fetuses. We show that relative to young (3–4 months) dams, advanced maternal age (9.5–10 months) compromises growth of both female and male fetus...
4 CitationsSource
#1Christy-Lynn M. Cooke (U of A: University of Alberta)H-Index: 9
#2Sandra T. Davidge (U of A: University of Alberta)H-Index: 54
Delaying pregnancy, which is on the rise, may increase the risk of cardiovascular disease in both women and their children. The physiological mechanisms that lead to these effects are not fully und...
1 CitationsSource
#1Tamara SáezH-Index: 15
Last. Sandra T. DavidgeH-Index: 54
view all 5 authors...
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#1F. Jahandideh (U of A: University of Alberta)
#2S. C. de Campos Zani (U of A: University of Alberta)
Last. Jianping Wu (U of A: University of Alberta)H-Index: 36
view all 7 authors...
Agents that block the renin–angiotensin system (RAS) improve glucoregulation in the metabolic syndrome disorder. We evaluated the effects of egg white hydrolysate (EWH), previously shown to modulate the protein abundance of RAS component in vivo , on glucose homeostasis in diet-induced insulin-resistant rats. Sprague–Dawley rats were fed a high-fat diet (HFD) for 6 weeks to induce insulin resistance. They were then randomly divided into four groups receiving HFD or HFD supplemented with differen...
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