Amrita K. Cheema
Georgetown University Medical Center
MetabolomicsBiochemistryMedicineBiomarker (medicine)Biology
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Publications 123
#1Meng Zhang (GUMC: Georgetown University Medical Center)H-Index: 1
#2Nisi Jiang (GUMC: Georgetown University Medical Center)
Last. Nady Golestaneh (GUMC: Georgetown University Medical Center)H-Index: 21
view all 8 authors...
Age-related macular degeneration is a major cause of vision impairment in the Western world among people of 55 years and older. Recently we have shown that autophagy is dysfunctional in the retinal pigment epithelium (RPE) of the AMD donor eyes (AMD RPE). We also showed increased reactive oxygen (ROS) production, increased cytoplasmic glycogen accumulation, mitochondrial dysfunction and disintegration, and enlarged and annular LAMP-1-positive organelles in AMD RPE. However, the underlying mechan...
#1Matthew A. Edwardson (Georgetown University)H-Index: 3
#2Xiaogang Zhong (Georgetown University)H-Index: 7
Last. Alexander W. Dromerick (Georgetown University)H-Index: 33
view all 6 authors...
#1Mingjun Tan (GUMC: Georgetown University Medical Center)H-Index: 1
#2Rami Mosaoa (KAU: King Abdulaziz University)
Last. Maria Laura Avantaggiati (GUMC: Georgetown University Medical Center)H-Index: 31
view all 14 authors...
Nonalcoholic fatty liver disease (NAFLD) and its evolution to inflammatory steatohepatitis (NASH) are the most common causes of chronic liver damage and transplantation that are reaching epidemic proportions due to the upraising incidence of metabolic syndrome, obesity, and diabetes. Currently, there is no approved treatment for NASH. The mitochondrial citrate carrier, Slc25a1, has been proposed to play an important role in lipid metabolism, suggesting a potential role for this protein in the pa...
#1Emma Kurnat-Thoma (Georgetown University)
#2Ancha Baranova (GMU: George Mason University)H-Index: 32
Last. James Giordano (GUMC: Georgetown University Medical Center)H-Index: 25
view all 42 authors...
#1Charles P. Hinzman (GUMC: Georgetown University Medical Center)H-Index: 2
#2Janet E. Baulch (UCI: University of California, Irvine)H-Index: 8
Last. Amrita K. Cheema (GUMC: Georgetown University Medical Center)H-Index: 22
view all 9 authors...
Ionizing radiation exposure to the brain is common for patients with a variety of CNS related malignancies. This exposure is known to induce structural and functional alterations to the brain, impacting dendritic complexity, spine density and inflammation. Over time, these changes are associated with cognitive decline. However, many of these impacts are only observable long after irradiation. Extracellular vesicles (EVs) are shed from cells in nearly all known tissues, with roles in many disease...
2 CitationsSource
#1Daniel W. BeardenH-Index: 21
#2David A. SheenH-Index: 11
Last. Daniel RafteryH-Index: 45
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There is a lack of experimental reference materials and standards for metabolomics measurements, such as urine, plasma, and other human fluid samples. Reasons include difficulties with supply, distribution, and dissemination of information about the materials. Additionally, there is a long lead time because reference materials need their compositions to be fully characterized with uncertainty, a labor-intensive process for material containing thousands of relevant compounds. Furthermore, data an...
#1Amrita K. Cheema (GUMC: Georgetown University Medical Center)H-Index: 22
#2Yaoxiang Li (GUMC: Georgetown University Medical Center)H-Index: 1
Last. Vijay K. Singh (Armed Forces Radiobiology Research Institute)H-Index: 34
view all 9 authors...
Although multiple radioprotectors are currently being investigated preclinically for efficacy and safety, few studies have investigated concomitant metabolic changes. This study examines the effects of amifostine on the metabolic profiles in tissues of mice exposed to cobalt-60 total-body gamma-radiation. Global metabolomic and lipidomic changes were analyzed using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS) in bone marrow, jejunum, and lu...
#1Jennifer Romanowicz (NIH: National Institutes of Health)
#2Camille Leonetti (NIH: National Institutes of Health)H-Index: 1
Last. Nobuyuki Ishibashi (NIH: National Institutes of Health)H-Index: 11
view all 12 authors...
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a...
#1Isabelle R. Miousse (University of Arkansas for Medical Sciences)H-Index: 17
#2Charles M. Skinner (University of Arkansas for Medical Sciences)H-Index: 6
Last. Igor Koturbash (University of Arkansas for Medical Sciences)H-Index: 31
view all 10 authors...
Abstract Cardiovascular disease constitutes an important threat to humans after space missions beyond the Earth's magnetosphere. Epigenetic alterations have an important role in the etiology and pathogenesis of cardiovascular disease. Previous research in animal models has shown that protons and 56 Fe ions cause long-term changes in DNA methylation and expression of repetitive elements in the heart. However, astronauts will be exposed to a variety of ions, including the smaller fragmented produc...
Exposure to ionizing radiation induces a complex cascade of systemic and tissue-specific responses that lead to functional impairment over time in the surviving population. However, due to the lack of predictive biomarkers of tissue injury, current methods for the management of survivors of radiation exposure episodes involve monitoring of individuals over time for the development of adverse clinical symptoms and death. Herein, we report on changes in metabolomic and lipidomic profiles in multip...