Sarah Durston
Utrecht University
Publications 103
#1Merel Postema (MPG: Max Planck Society)H-Index: 1
#2Daan van RooijH-Index: 12
Last.Clyde Francks (MPG: Max Planck Society)H-Index: 42
view all 58 authors...
Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface...
Missing heritability is a common problem in psychiatry that impedes precision medicine approaches to autism and other heritable complex disorders. This proof-of-concept study uses a systematic review and meta-analysis of the association between variants of the serotonin transporter promoter (5-HTTLPR) and autism to explore the hypothesis that some missing heritability can be explained using an optimum curve. A systematic literature search was performed to identify transmission disequilibrium tes...
1 CitationsSource
#1Sophie E.A. Akkermans (Radboud University Nijmegen)H-Index: 4
#2N. Rheinheimer (Radboud University Nijmegen)H-Index: 1
Last.Philippe AubyH-Index: 1
view all 24 authors...
1 CitationsSource
#1Siemon C. de Lange (VU: VU University Amsterdam)H-Index: 4
#2Lianne H. Scholtens (VU: VU University Amsterdam)H-Index: 12
Last.Martijn P. van den Heuvel (VU: VU University Amsterdam)H-Index: 8
view all 21 authors...
Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study ...
5 CitationsSource
#2Daan van RooijH-Index: 12
Last.Odile A. van den HeuvelH-Index: 26
view all 221 authors...
ABSTRACT Objective Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positioned to investigate structural brain alterations across these disorders. Methods Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD (n=2,271), ASD (n=1,777), and OCD (n=2,3...
#1Aaltsje Malda (UG: University of Groningen)H-Index: 1
#2Nynke Boonstra (Stenden University of Applied Sciences)H-Index: 8
Last.Gerdina H. M. Pijnenborg (UG: University of Groningen)H-Index: 10
view all 34 authors...
Background: The Clinical High Risk state for Psychosis (CHR-P) has become the cornerstone of modern preventive psychiatry. The next stage of clinical advancements rests on the ability to formulate a more accurate prognostic estimate at the individual subject level. Individual Participant Data Meta-Analyses (IPD-MA) are robust evidence synthesis methods that can also offer powerful approaches to the development and validation of personalized prognostic models. The aim of the study was to develop ...
6 CitationsSource
#1Martijn P. van den Heuvel (UU: Utrecht University)H-Index: 8
#2Lianne H. Scholtens (UU: Utrecht University)H-Index: 12
Last.Siemon C. de Lange (UU: Utrecht University)H-Index: 4
view all 114 authors...
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.
1 CitationsSource
#1Bram Gooskens (UU: Utrecht University)
#2Dienke J. Bos (UU: Utrecht University)H-Index: 11
Last.Sarah Durston (UU: Utrecht University)H-Index: 36
view all 12 authors...
Abstract Repetitive behaviors are among the core symptoms of both Autism Spectrum Disorder (ASD) and Obsessive-Compulsive Disorder (OCD) and are thought to be associated with impairments in cognitive control. However, it is still unknown how deficits in cognitive control and associated neural circuitry relate to the quality or severity of repetitive behavior in children with these disorders. Therefore, we investigated the behavioral and neural correlates of cognitive control using a modified sto...
#1Julian Tillmann (University of Vienna)H-Index: 6
#2Antonia San José Cáceres ('KCL': King's College London)H-Index: 3
Last.Tony Charman ('KCL': King's College London)H-Index: 78
view all 17 authors...
Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 childre...
3 CitationsSource
#1Merel Postema (MPG: Max Planck Society)H-Index: 1
#2Daan van RooijH-Index: 12
Last.Clyde Francks (MPG: Max Planck Society)H-Index: 42
view all 57 authors...
Abstract Background Left-right asymmetry is an important organizing feature of the healthy brain. Various studies have reported altered structural brain asymmetry in autism spectrum disorder (ASD). However, findings have been inconsistent, likely due to limited sample sizes and low statistical power. Methods We investigated 1,774 subjects with ASD and 1,809 controls, from 54 datasets, for differences in the asymmetry of thickness and surface area of 34 cerebral cortical regions. We also examined...
1 CitationsSource