Richard A. Dixon
University of North Texas
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Publications 585
#1Lina Gallego-Giraldo (UNT: University of North Texas)H-Index: 4
#2Chang Liu (UNT: University of North Texas)H-Index: 1
Last. J. Paul Knox (University of Leeds)H-Index: 52
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There is considerable interest in engineering plant cell wall components, particularly lignin, to improve forage quality and biomass properties for processing to fuels and bioproducts. However, modifying lignin content and/or composition in transgenic plants through down-regulation of lignin biosynthetic enzymes can induce expression of defense response genes in the absence of biotic or abiotic stress. Arabidopsis thaliana lines with altered lignin through down-regulation of hydroxycinnamoyl CoA...
1 CitationsSource
#1Li Wang (BFU: Beijing Forestry University)H-Index: 4
#2Jiawen Cui (YZU: Yangzhou University)H-Index: 3
Last. Jinxing Lin (BFU: Beijing Forestry University)
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Aging is a universal property of multicellular organisms. Although some tree species can live for centuries or millennia, the molecular and metabolic mechanisms underlying their longevity are unclear. To address this, we investigated age-related changes in the vascular cambium from 15- to 667-y-old Ginkgo biloba trees. The ring width decreased sharply during the first 100 to 200 y, with only a slight change after 200 y of age, accompanied by decreasing numbers of cambial cell layers. In contrast...
#1Jaime Barros (UNT: University of North Texas)H-Index: 3
#2Richard A. Dixon (UNT: University of North Texas)H-Index: 120
Aromatic amino acid deaminases are key enzymes mediating carbon flux from primary to secondary metabolism in plants. Recent studies have uncovered a tyrosine ammonia-lyase that contributes to the typical characteristics of grass cell walls and contributes to about 50% of the total lignin synthesized by the plant. Grasses are currently preferred bioenergy feedstocks and lignin is the most important limiting factor in the conversion of plant biomass to liquid biofuels, as well as being an abundant...
1 CitationsSource
#1Richard A. Dixon (A&M: Texas A&M University)H-Index: 120
#2Jaime Barros (UNT: University of North Texas)H-Index: 3
Lignin is a major component of secondarily thickened plant cell walls and is considered to be the second most abundant biopolymer on the planet. At one point believed to be the product of a highly ...
#1Evert K. Holwerda (Dartmouth College)H-Index: 10
#2Robert S. Worthen (Dartmouth College)H-Index: 3
Last. Lee R. Lynd (Dartmouth College)H-Index: 60
view all 23 authors...
Background The recalcitrance of cellulosic biomass is widely recognized as a key barrier to cost-effective biological processing to fuels and chemicals, but the relative impacts of physical, chemical and genetic interventions to improve biomass processing singly and in combination have yet to be evaluated systematically. Solubilization of plant cell walls can be enhanced by non-biological augmentation including physical cotreatment and thermochemical pretreatment, the choice of biocatalyst, the ...
6 CitationsSource
#1Hongli Xie (DOE: United States Department of Energy)H-Index: 1
#2Nancy L. Engle (ORNL: Oak Ridge National Laboratory)H-Index: 1
Last. Yuhong Tang (DOE: United States Department of Energy)H-Index: 37
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Downregulation of genes involved in lignin biosynthesis and related biochemical pathways has been used as a strategy to improve biofuel production. Plant C1 metabolism provides the methyl units used for the methylation reactions carried out by two methyltransferases in the lignin biosynthetic pathway: caffeic acid 3-O-methyltransferase (COMT) and caffeoyl-CoA 3-O-methyltransferase (CCoAOMT). Mutations in these genes resulted in lower lignin levels and altered lignin compositions. Reduced lignin ...
1 CitationsSource
#1Evert K. Holwerda (Dartmouth College)H-Index: 10
#2Robert S. Worthen (Dartmouth College)H-Index: 3
Last. Lee R. Lynd (Dartmouth College)H-Index: 60
view all 23 authors...
Following publication of the original article [1], the authors reported that the omission of author name.
#1Jaime Barros (UNT: University of North Texas)H-Index: 3
#2Luis Escamilla-Trevino (UNT: University of North Texas)H-Index: 7
Last. Richard A. DixonH-Index: 120
view all 12 authors...
Lignin biosynthesis is evolutionarily conserved among higher plants and features a critical 3-hydroxylation reaction involving phenolic esters. However, increasing evidence questions the involvement of a single pathway to lignin formation in vascular plants. Here we describe an enzyme catalyzing the direct 3-hydroxylation of 4-coumarate to caffeate in lignin biosynthesis as a bifunctional peroxidase that oxidizes both ascorbate and 4-coumarate at comparable rates. A combination of biochemical an...
3 CitationsSource
#2Emilio A. MendiolaH-Index: 1
Last. Michael S. SacksH-Index: 69
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Introduction: Right ventricular (RV) function is the primary determinant of pulmonary arterial hypertension (PAH) patients survival. Our recent studies suggested that, in response to pressure overl...
Last. Qi LiuH-Index: 6
view all 7 authors...
Introduction: Because patients with atrial fibrillation (AF) who have a CHA2DS2-VASc score >2 are at high risk for stroke, long-term anticoagulation therapy is recommended. Venous thromboembolism (...