Henrik Wiggers
Aarhus University Hospital
CardiologyHeart failureDiabetes mellitusMedicineEjection fraction
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Publications 96
#1Anne Ankerstjerne Rasmussen (Aarhus University Hospital)
#2Søren Paaske Johnsen (AAU: Aalborg University)H-Index: 54
Last. Signe Holm Larsen (Aarhus University Hospital)H-Index: 8
view all 10 authors...
Background:It is well-established that heart failure has a negative impact on quality of life. However, little is known about patient-related predictors of health-related quality of life, anxiety a...
#1Mette Asbjoern Neergaard (Aarhus University Hospital)H-Index: 14
#2Marianne Hjorth Skorstengaard (Aarhus University Hospital)H-Index: 4
Last. Anders Bonde Jensen (Aarhus University Hospital)H-Index: 36
view all 9 authors...
Advance care planning (ACP) can be a way to meet patients’ end-of-life preferences and increase awareness and quality of end-of-life care. In a recent publication, we investigated the effect of ACP in a randomised controlled trial of incurably ill patients with mixed diagnoses within the areas of cancer, lung and cardiac diseases.1 We found that ACP did not affect fulfilment of preferences concerning place of death and hospitalisation. However, a significantly higher percentage of patients died ...
1 CitationsSource
#1Anders Jorsal (Aarhus University Hospital)H-Index: 17
#1Anders Jorsal (Aarhus University Hospital)H-Index: 8
Last. Roni Nielsen (Aarhus University Hospital)H-Index: 13
view all 7 authors...
Background Device therapy in addition to medical treatment improves prognosis in a subset of patients with heart failure and reduced ejection fraction. However, some patients remain symptomatic or their heart failure even progresses despite cardiac resynchronization therapy (CRT). The aim of the study was to evaluate the proportion of patients who could benefit from optimization of medical therapy using sacubitril/valsartan, ivabradine, or both following CRT implantation.
4 CitationsSource
#1Rasmus Stilling Tougaard (AU: Aarhus University)H-Index: 5
#2Anders Jorsal (AU: Aarhus University)H-Index: 8
Last. Henning Mølgaard (Aarhus University Hospital)H-Index: 20
view all 13 authors...
Background. Liraglutide, a glucagon-like peptide-1 agonist, is used for treatment of type 2 diabetes and has beneficial cardiovascular properties. However, treatment increases heart rate (HR) and possibly the risk of cardiovascular events in chronic heart failure (CHF) patients. We investigated potential associations between HR changes and clinical, laboratory and echocardiographic parameters and clinical events in liraglutide treated CHF patients. Methods. This was a sub-study of the LIVE study...
#1Anne Ankerstjerne Rasmussen (Aarhus University Hospital)
#1Anne Ankerstjerne Rasmussen (Aarhus University Hospital)
Last. Henrik Wiggers (Aarhus University Hospital)H-Index: 17
view all 11 authors...
AIMS: An in-depth understanding of the prognostic value of patient-reported outcomes (PRO) is essential to facilitate person-centred care in heart failure (HF). This study aimed to clarify the prognostic role of subjective mental and physical health status in patients with HF. METHODS AND RESULTS: Patients with HF were identified from the DenHeart Survey (n = 1,499) and PRO data were obtained at hospital discharge, including the EuroQol five-dimensional questionnaire (EQ-5D), the HeartQoL and th...
#1Magnus Giske Snipsøyr (AU: Aarhus University)H-Index: 1
#2Henrik Wiggers (Aarhus University Hospital)H-Index: 17
Last. Bent Honoré (AU: Aarhus University)H-Index: 36
view all 9 authors...
Abstract Introduction Infective endocarditis (IE) has high mortality, partly due to delayed diagnosis. No biomarker can identify IE in patients with fever and clinical picture of infection. To find putative biomarkers we analyzed serum levels of two proteins found in cardiac valves, fibulin-1 (n = 696) and osteoprotegerin (n = 689) among patients on clinical suspicion of IE. Proteomic analyses were performed in 24 patients with bacteremia, 12 patients with definite IE and 12 patients with exclud...
#1Anders Hostrup Larsen (Aarhus University Hospital)H-Index: 3
#2Niels Jessen (AU: Aarhus University)H-Index: 40
Last. Henrik Wiggers (Aarhus University Hospital)H-Index: 17
view all 13 authors...
AIMS: The present study tested the hypothesis that metformin treatment may increase myocardial efficiency (stroke work/myocardial oxygen consumption) in insulin-resistant patients with heart failure and reduced ejection fraction (HFrEF) without diabetes. METHODS AND RESULTS: Thirty-six HFrEF patients (ejection fraction 37 +/- 8%; median age 66 years) were randomised to metformin (n = 19) or placebo (n = 17) for 3 months in addition to standard heart failure therapy. The primary endpoint was chan...
3 CitationsSource
#1Roni Nielsen (AU: Aarhus University)H-Index: 13
#2Jens Laurids Sørensen (AU: Aarhus University)H-Index: 19
Last. Hendrik J. Harms (Aarhus University Hospital)H-Index: 23
view all 10 authors...
AIMS: Left ventricular filling pressure (preload) can be assessed by pulmonary capillary wedge pressure (PCWP) during pulmonary arterial catheterization (PAC). An emerging method [pulse indexed contour cardiac output (PICCO)] can estimate preload by global end-diastolic volume (GEDV) and congestion as extravascular lung water (EVLW) content. However, no reliable quantitative non-invasive methods are available. Hence, in a porcine model of pulmonary congestion, we evaluated EVLW and GEDV by posit...
#1Kasper Pryds (AU: Aarhus University)H-Index: 5
#2Anders Hostrup Larsen (AU: Aarhus University)H-Index: 1
Last. Roni Nielsen (AU: Aarhus University)H-Index: 13
view all 12 authors...
Myocardial deformation assessed by speckle tracking echocardiography (STE) is increasingly used for diagnosis, monitoring and prognosis in patients with clinical and pre-clinical cardiovascular diseases. Feature tracking cardiac magnetic resonance (FT-CMR) also allows myocardial deformation analysis. To clarify whether the two modalities can be used interchangeably, we compared myocardial deformation analysis by FT-CMR with STE in patients with a variety of cardiovascular diseases and healthy su...
1 CitationsSource
#2Wayne C. Levy (UW: University of Washington)H-Index: 45
Last. Jens Jakob ThuneH-Index: 23
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Abstract Objectives This study aims to identify patients with nonischemic heart failure who are more likely to benefit from implantable cardioverter-defibrillator (ICD) implantation by use of established risk prediction models. Background It has been debated whether an ICD for primary prevention reduces mortality in patients with nonischemic heart failure. Methods The Seattle Heart Failure Model (SHFM) predicts all-cause mortality whereas the Seattle Proportional Risk Model (SPRM) predicts the p...
8 CitationsSource